Clinical trials: HSV, open to volunteers
Herpes Zoster
A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant
The purpose of this study is to evaluate the reactogenicity, safety and immunogenicity of 2 doses of PED-HZ/su, GSK's vaccine candidate for the prevention of Herpes Zoster (HZ) in immunocompromised paediatric renal transplant…
- Trial name
- NCT04006808
- Testing
- PED-HZ/su
- Where
- 31 sites in Belgium, France and 4 more
- Volunteers
- 184 people
- Sponsor
- GlaxoSmithKline
Oral Mucositis, Head and Neck Cancer (H&N)
Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy
Patients receiving radiotherapy for head and neck cancer often develop oral mucositis, a painful condition that causes redness and sores in the mouth.
- Conditions
- Oral Mucositis, Head and Neck Cancer (H&N), Radiotherapy Side Effects
- Trial name
- NCT07363031
- Testing
- Valacyclovir
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Instituto Oncoclinicas
Herpes Zoster
Immunogenicity and Safety of SYS6017 in the Participants Aged 40 Years and Above
Herpes zoster is caused by the reactivation of latent varicella-zoster virus (VZV) which stays in latency after its primary infection. Immunosenescence contributes significantly to elevating morbidity associated with aging.
- Trial name
- NCT07354659
- Testing
- A zoster mRNA vaccine SYS6017, Active Comparator Vaccine
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- CSPC Megalith Biopharmaceutical Co.,Ltd.
Calcitonin, Subcutaneous
Subcutaneous Calcitonin in Acute Herpes Zoster
This prospective randomized controlled study will be conducted to evaluate the effect of adding calcitonin to the standard treatment protocol in patients with acute herpes zoster infection.
- Conditions
- Calcitonin, Subcutaneous, Acute Herpes Zoster
- Trial name
- NCT07655804
- Testing
- Calcitonin, Saline
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Tanta University
Advanced Solid Tumors
A Clinical Study of T3011 in Combination With PD-1/PD-L1 Inhibitors in Subjects With Advanced Solid Tumors
This clinical study evaluated the efficacy and safety of T3011 in combination with PD-1/PD-L1 inhibitors in subjects with advanced solid tumors
- Trial name
- NCT06214143
- Testing
- T3011 high dose, T3011 middle dose, T3011 low dose
- Where
- 22 sites in China
- Volunteers
- 68 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Vaccine, Varicella-zoster Virus
Comparative Study of Two Vaccination Schedules for the Subunit Herpes Zoster Vaccine in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disease Patients Treated With Anti-CD20 Therapy: an Open-label Randomised Controlled Trial
Immunocompromised individuals, such as patients with multiple sclerosis (MS) or diseases of the neuromyelitis optica spectrum (NMOSD) treated with an anti-CD20 monoclonal antibody, present an increased risk of shingles.
- Conditions
- Vaccine, Varicella-zoster Virus, Multiple Sclerosis, Spectrum Disease Neuromyelitis Optica
- Trial name
- TACTIC (NCT07818356)
- Testing
- Two-dose M0-M2 vaccination schedule, Two-dose M0-M6 vaccination schedule
- Where
- 24 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Toulouse
Herpesviridae Infections, Herpes Simplex 1
Pharmacokinetics of Intravenous Acyclovir in Oncologic Paediatric Patients
Herpesvirus infections may be severe in immunocompromised patients, with a high risk of complications and mortality. Recipients of hematopoietic stem cell transplant (HSCT) or patients receiving high-intensity chemotherapy for…
- Conditions
- Herpesviridae Infections, Herpes Simplex 1, Varicella Zoster Virus Infection, Transplantation Infection
- Trial name
- NCT05198570
- Testing
- Pharmacokinetic analysis
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Pisa
Herpes Zoster Pain
Efficacy and Safety of Intravenous Dexamethasone Palmitate Treatments in Acute and Subacute Herpes Zoster Pain
This is a randomized, prospective, multicenter, open-label, blinded-endpoint study investigating the efficacy and safety of dexamethasone palmitate (DXP) for treating acute and subacute herpes zoster (shingles) pain.
- Trial name
- NCT07344246
- Testing
- intravenous infusion with 4 mg dexamethasone palmitate or 8 mg dexamethasone palmitate
- Where
- China
- Volunteers
- 954 people
- Sponsor
- Beijing Tiantan Hospital
Herpes Simplex 2, Meningitis, Viral
Aciclovir Versus Placebo for HSV-2 Meningitis
To determine whether active treatment with (val)acyclovir is superior for treatment of viral meningitis compared with placebo assessed by numbers meeting a primary, objective endpoint at 7 days after randomisation
- Trial name
- AMEN (NCT05452928)
- Testing
- Acyclovir 50 MG/ML
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jacob Bodilsen
Prevention of Herpes Zoster
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IV Clinical Trial to Evaluate the Immunogenicity and Safety of a Live Attenuated Herpes Zoster Vaccine in Adults Aged 40 Years and Older
To evaluate the immunogenicity 42 days after vaccination with the live attenuated herpes zoster vaccine. To evaluate the safety of the live attenuated herpes zoster vaccine.
- Trial name
- NCT06961721
- Testing
- Herpes Zoster Vaccine, Live
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Changchun BCHT Biotechnology Co.
Herpes Zoster
A Study to Evaluate the Effect of Recombinant Zoster Vaccine on New Diagnosis of Dementia in an Older Adult Population Aged 76 Years or Older in Finland
The purpose of this study is to evaluate the effect of the recombinant zoster vaccine on the risk of new diagnosis of dementia among adults aged 76 years or older in Finland.
- Trial name
- NCT07502560
- Testing
- Recombinant zoster vaccine
- Where
- 8 sites in Finland
- Volunteers
- 33,609 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Herpes Zoster, Quality of Life
Impact on Quality of Life and Burden of Disease in Adults With Herpes Zoster
Title: Impact on quality of life and disease burden in adults with herpes zoster Prospective cohort study for the primary objective and the secondary objectives (1 and 2) and retrospective cohort study for the secondary objective…
- Conditions
- Herpes Zoster, Quality of Life, Immunization; Infection
- Trial name
- NCT06667245
- Where
- Spain
- Volunteers
- 357 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Chronic Active Epstein-Barr Virus
Genetic Studies of Chronic Active Epstein-Barr Disease
Epstein-Barr virus (EBV) is a member of the human herpes virus family that infects more than 95 percent of the U.S. population. Most infections occur in childhood and cause no symptoms; in adolescents and adults, EBV often causes…
- Trial name
- NCT00032513
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kaposi Sarcoma
Recombinant Glycosylated Human Interleukin-7 (CYT107) for the Treatment of Kaposi Sarcoma in Participants With HIV and Immune Non-Response (REGIMENKS HIV)
Background: Kaposi sarcoma (KS) is a cancer that causes abnormal tissue to grow in the skin, lymph nodes, and other organs. KS is caused by a virus known as Kaposi sarcoma herpesvirus.
- Trial name
- NCT07308886
- Testing
- CYT107
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Midpoint Transverse Process to Pleura Block, Erector Spinae Plane Block
Midpoint Transverse Process to Pleura (MTP) Block vs Erector Spinae Plane (ESP) Block for Acute Herpes Zoster (HZ) Pain
The aim of this study is to compare the analgesic efficacy and safety of ultrasound-guided midpoint transverse process block versus ultrasound-guided erector spinae plane block in patients suffering from thoracic herpes zoster…
- Conditions
- Midpoint Transverse Process to Pleura Block, Erector Spinae Plane Block, Acute Herpes Zoster, Pain
- Trial name
- NCT07732556
- Testing
- Midpoint transverse process to pleura block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Nasopharyngeal Carcinoma, Herpesvirus 4, Human
Deep Learning-based sbORN Diagnostic Model
Skull-base osteonecrosis (sbORN) is a severe long-term complication of nasopharyngeal carcinoma (NPC) post radiotherapy, which significantly diminish the quality of life, increase the risk of internal carotid artery rupture, and…
- Trial name
- NCT06463392
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lymphoma, Primary Effusion
Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease
Background: Primary effusion lymphoma (PEL), plasmablastic lymphoma (PBL), and Multicentric Castleman Disease (MCD) are aggressive forms of cancer that affects cells in the immune system and lymph nodes.
- Trial name
- NCT05907759
- Testing
- Daratumumab SC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Severe Pneumonia
Herpes Simplex Virus Type 1 Infection/Reactivation of Patients With Severe Pneumonia（the HSV-SP Study）
Severe pneumonia(SP) is a one of the main causes of death for critically ill patients.Samples of bronchoalveolar lavage fluid (BALF) from SP patients often report positive for herpes simplex virus type 1 (HSV-1) DNA.
- Trial name
- NCT06936683
- Testing
- Bronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy, throat Swab
- Volunteers
- 323 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Herpes Zoster Pain, Neuralgia, Postherpetic
High-Voltage Long-Duration Pulsed Radiofrequency Combined With Liposomal Bupivacaine Subcutaneous Block for Herpes Zoster-Associated Neuralgia
Research Objectives Background and Significance: Zoster-associated neuralgia (ZAN) refers to neuropathic pain experienced by herpes zoster (HZ) patients before, during, and after rash resolution, characterized by paroxysmal…
- Trial name
- NCT06959147
- Testing
- High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shirong Tan