Clinical trials: HYPERGLYCEMIA
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Comparison of Glycemic Control in Obese Diabetics Using Three Different Pen Needles
Anxiety about needles is a concern commonly expressed by diabetics when beginning insulin therapy. A shorter, thinner pen needle that delivers insulin with the safety and efficacy profile of longer pen needles may appeal to many…
- Trial name
- NCT01231984
- Testing
- 4 mm x 32G Pen Needle, 8mm x 31G Pen Needle, 12.7mm x 29G Pen Needle
- Where
- 10 sites in United States
- Volunteers
- 293 people
- Sponsor
- Becton, Dickinson and Company
Stress Hyperglycemia
Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery Patients
This study is a prospective randomized study to examine the effects of exposure to dulaglutide on the prevention of stress-hyperglycemia and the metabolic inflammatory response in the perioperative period.
- Trial name
- NCT03743025
- Testing
- Dulaglutide Injection, Saline Injection
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Emory University
PreDiabetes
Augmented Care at Worksite for Diabetes Prevention
The purpose of the study was to evaluate the impact of augmented care at the worksite through a lifestyle intervention for diabetes prevention among employees with prediabetes who were slower to respond to a standard diabetes…
- Trial name
- NCT03382873
- Testing
- Group Lifestyle Balance (GLB), Group Lifestyle Balance Plus (GLB+)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Ohio State University
Type 2 Diabetes Treated With Insulin
Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Hyperglycemia affects 30-40% of hospitalized patients. Despite the fact that basal/bolus insulin therapy has been demonstrated to improve glycemic control and clinical outcomes in patients, achieving good glucose control remains…
- Trial name
- In-FI (NCT04460326)
- Testing
- Insulin glargine, NovoLog, Insulin Fiasp
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Boston Medical Center
Type 1 Diabetes, Type2 Diabetes
Continuous Glucose Monitoring Initiation at Hospital Discharge
The purpose of this study is to look at feasibility (the likelihood) of continued use of the FreeStyle Libre 2 Continuous glucose monitor (CGM) when started at the time of hospital discharge in patients with poorly controlled…
- Conditions
- Type 1 Diabetes, Type2 Diabetes, Hyperglycemia, Hypoglycemia
- Trial name
- CGM4Home (NCT04854135)
- Testing
- CGM4Home
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Hyperglycaemia (Diabetic)
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose
To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.
- Trial name
- NCT03469492
- Testing
- Insulin, exercise, Dietary counseling
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Diabetes Mellitus
Dexcom G6 Intervention Study
The study will assess if Continuous Glucose Monitoring (CGM) represents a better tool to guide healthcare providers in adjusting insulin therapy, by providing a more complete 24-hour assessment of glucose values compared to Point…
- Trial name
- NCT03877068
- Testing
- Dexcom G6 CGM - Continues Glucose Monitoring sensor system, POC BG - Point-of-Care Blood Glucose monitoring
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- Emory University
Diabetes Mellitus, Type 2
Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes
The purpose of this study is to test whether using extra doses of aspart insulin to correct blood sugars before meals improves the care of patients with type 2 diabetes in the hospital who are already receiving the standard of…
- Trial name
- NCT02408120
- Testing
- Insulin glargine, Insulin aspart, Supplemental insulin aspart
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- Emory University
Type 2 Diabetes, Hyperglycemia Due to Type 2 Diabetes Mellitus
CGM Use in Children With Type 2 Diabetes
The purpose of this prospective study is to determine if trial use of a Dexcom G6 CGM system for a 10 day wear period in pediatric Type 2 diabetes patients improves short term time in range glucose control and 3-6 month glycemic…
- Trial name
- IMPaCT2 (NCT04721158)
- Testing
- Continuous glucose monitor
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Avoidance of Hyperglycaemia in People With Type 1 Diabetes
This study aims to learn more about avoidance of hyperglycaemia in adults with type 1 diabetes. People who attend a type 1 diabetes clinic will be invited to complete a number of self-report questionnaires and a survey.
- Trial name
- HYPE (NCT04732780)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- Imperial College London
Type 1 Diabetes, Hypoglycemia
CGM Use in Poorly Controlled Youth With Type 1 Diabetes
The purpose of this prospective study is to determine if trial use of a Dexcom G6 CGM system for a 10 day wear period in high risk, poorly controlled pediatric Type 1 diabetes patients increases uptake of personal CGM use, and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, High Blood Sugar
- Trial name
- IMPaCT (NCT04721145)
- Testing
- Dexcom G6 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Johns Hopkins University
Diabetes, PreDiabetes
Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial
The proposed randomized controlled trial will test the effect of a low-carbohydrate diet on hemoglobin A1c among individuals with elevated hemoglobin A1c that are within the range of prediabetes or diabetes.
- Conditions
- Diabetes, PreDiabetes, Metabolic Disease, Hyperglycemia
- Trial name
- ADEPT (NCT03675360)
- Testing
- Low-Carbohydrate Diet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Public Health and Tropical Medicine
Diabetes Mellitus Type 2 With Hyperglycemia
Hydroxychloroquine Versus Pioglitazone in Combination Treatment for Type 2 Diabetes Mellitus
A 4-month, randomized, prospective, open-label comparison trial of hydroxychloroquine vs. pioglitazone in type 2 diabetic patients inadequately controlled on maximally tolerated doses of metformin plus a sulfonylurea.
- Trial name
- NCT02303405
- Testing
- Hydroxychloroquine, Pioglitazone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Charles Drew University of Medicine and Science
Type 1 Diabetes, Hyperglycemia, Postprandial
Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes
Glucagon regulation and response in persons with T1D at the basal state and in response to various stimuli remains unclear. Dr. Philip Cryer has previously reported that, in T1D young adults with a course of the disease of 16+9…
- Trial name
- NCT04079881
- Testing
- Insulin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Heart Defects, Congenital, Hyperglycemia
SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
Critically ill children, including children undergoing heart surgery, commonly develop elevated blood glucose (also known as "blood sugar") levels during their illness, which can lead to poor health outcomes and an increased risk…
- Trial name
- SPECS (NCT00443599)
- Testing
- Insulin, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 989 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Type 1
Effects of Micronutrient (Chromium) Supplementation on Diabetes
6-8% of USA population has diabetes. Intensive blood glucose control dramatically reduces the devastating complications that result from poorly controlled diabetes.
- Trial name
- NCT01709123
- Testing
- chromium niacinate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Pancreatic Leak, Pancreatic Fistula
A Phase II Trial of Lanreotide for the Prevention of Postoperative Pancreatic Fistula
This is a single arm investigator-initiated study designed to test the feasibility and potential efficacy of preoperative lanreotide to reduce the risk of postoperative abscess or pancreatic leak and fistula.
- Conditions
- Pancreatic Leak, Pancreatic Fistula, Pancreaticoduodenal; Fistula, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03174353
- Testing
- Lanreotide Prefilled Syringe
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Washington
Pregnancy Preterm, Neonatal Hypoglycemia
Euglycemia After Antenatal Late Preterm Steroids, the E-ALPS Study
Annually in the U.S 300,000 neonates are born late preterm, defined as 34 weeks 0 days - 36 weeks 6 days. The Antenatal Late Preterm Steroids (ALPS) Trial demonstrated that maternal treatment with betamethasone in the late…
- Conditions
- Pregnancy Preterm, Neonatal Hypoglycemia, Hyperglycemia Drug Induced
- Trial name
- E-ALPS (NCT03076775)
- Testing
- Maternal glycemic control
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Euglycemia, Hypoglycemia
Intravenous Exenatide (Byetta) During Surgery
The purpose of this project is to study if intravenous Exenatide is effective at maintaining normal blood glucose levels and preventing low blood glucose levels during surgery.
- Conditions
- Euglycemia, Hypoglycemia, Hyperglycemia
- Trial name
- NCT00882050
- Testing
- Exenatide 0.27 ng/kg/min, Exenatide 0.41 ng/kg/min
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Thomas Jefferson University