Clinical trials: Haemorrhagic Shock
Stroke, Ischemic, Stroke Hemorrhagic
Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance and Balance:
This study assess the relationship between lower limb spasticity and trunk movements during static and dynamic balance in post-stroke patients who also underwent conventional physical therapy, visual feedback balance training and…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke, Spastic Gait
- Trial name
- NCT05196633
- Testing
- radial extracorporeal shock wave therapy
- Where
- Romania
- Volunteers
- 23 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Dengue
Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3/4delta30[ME]) in Healthy Adults
Dengue fever, caused by dengue viruses, is a major health problem in the tropical and subtropical regions of the world. The purpose of this study is to test the safety of and immune response to a new dengue virus vaccine in…
- Trial name
- NCT00375726
- Testing
- rDEN3/4delta30(ME)
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Critical Illness, ARDS
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.
- Conditions
- Critical Illness, ARDS, Septic Shock, Multiple Trauma
- Trial name
- Replenish (NCT03480555)
- Testing
- Replenish Protein, Standard protein
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdullah International Medical Research Center
Hemorrhage, Cardiac Surgery
Biological and Clinical Relevance of Quantra Viscoelastic Hemostatic Assay in Hemorrhagic Cardiac Surgery
The goal of this observational study is to assess the correlation between Quantra viscoelastometric assay and laboratory hemostasis biology in a cardiac surgery cohort presenting with acute hemorrhage in the operating room.
- Conditions
- Hemorrhage, Cardiac Surgery, Hemorrhagic Shock
- Trial name
- QASH (NCT07105904)
- Testing
- Viscoelastometric hemostatic assay
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Pitié-Salpêtrière Hospital
Wounds and Injuries, Traumatic Shock
Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model
Management of post-traumatic severe hemorrhage remains a challenge to any trauma care system. Studying integrated and innovative tools designed to predict the risk of early severe hemorrhage (ESH) and resource needs could offer a…
- Conditions
- Wounds and Injuries, Traumatic Shock, Hemorrhagic Shock
- Trial name
- SHOCKMATRIX (NCT06270615)
- Testing
- Ambispective validation of machine learning-based predictive model
- Where
- 8 sites in France
- Volunteers
- 1,584 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure, Shock
Comparing Post Cardiac Surgery Outcomes in ESRD Patient's With Early Dialysis Versus Standard Care
End-stage renal disease (ESRD) is an important risk factor for coronary and valvular cardiac disease leading to cardiac surgery.
- Conditions
- Respiratory Failure, Shock, Coagulopathy
- Trial name
- NCT04705701
- Testing
- Hemodialysis
- Sponsor
- Northwell Health
Hemorrhage, Trauma
Evaluation of Transthoracic Echocardiography Parameters and Their Changes in Blood Donor Volunteers
This study investigates the impact of blood donation on transthoracic echocardiography (TTE) parameters in healthy volunteers, aiming to enhance the understanding of hemodynamic changes associated with mild blood loss and assess…
- Conditions
- Hemorrhage, Trauma, Shock Hypovolemic
- Trial name
- EDoS (NCT07207629)
- Testing
- Transthoracic Echocardiography measurements
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Traumatic Shock, Hemorrhagic Shock
Prehospital Norepinephrine and Early Mortality in Traumatic Shock
The effect of early, prehospital norepinephrine use in patients with traumatic shock on mortality is unknown. Recent existing observational evidence from single system data (US, France, Japan) are conflicting.
- Conditions
- Traumatic Shock, Hemorrhagic Shock, Traumatic Brain Injury, Hypotension and Shock
- Trial name
- NCT04497155
- Testing
- Norepinephrine
- Volunteers
- 2,164 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Trauma, Hemorrhagic Shock
Phase 2c Dose Comparison Study of MP4OX in Trauma
MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen…
- Conditions
- Trauma, Hemorrhagic Shock, Lactic Acidosis
- Trial name
- NCT01973504
- Testing
- MP4OX, Control
- Where
- 31 sites in Australia, Belgium and 9 more
- Sponsor
- Sangart
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke, Ischemic, Stroke Hemorrhagic
Extracorporeal Shock Wave Therapy and Assessment Strategy Through a Novel Gait Analysis Tool for Post-stroke Spasticity
The aim of this study is to objectively evaluate the effectiveness of radial extracorporeal shock wave therapy (rESWT) and conventional physical therapy program on the gait pattern through a new gait analysis system which…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity, Muscle, Spastic Gait
- Trial name
- NCT05206240
- Testing
- Radial extracorporeal shock wave therapy and conventional physical therapy
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Mortality Rate, Hemorrhagic Shock
Low Dose of Norepinephrine Within 24-Hour Mortality in Traumatic Patient With Hemorrhagic Shock
The aim of the work is to evaluate role of low dose of nor epinephrine administration in the early 24-hour period among traumatic patients and hemorrhagic shock. The primary outcome: evaluate mortality at first 24 hour.
- Trial name
- NCT07053163
- Testing
- Crystalloid and blood as resuscitation, crystalloid, blood and low dose of norepinephrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Sepsis, Disseminated Intravascular Coagulation
An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan
This is an observational study in which data already collected from people with sepsis (blood poisoning) and/or disseminated intravascular coagulation (DIC) are studied.
- Trial name
- NCT06373159
- Testing
- No study intervention
- Where
- Japan
- Volunteers
- 5,740 people
- Sponsor
- Bayer
Hemorrhagic Shock, Traumatic Brain Injury
Hypertonic Modulation of Inflammation Following Injury
This project seeks to determine the effect of prehospital resuscitation with hypertonic saline vs. conventional crystalloids on the inflammatory response after injury.
- Trial name
- NCT00750997
- Testing
- hypertonic saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 119 people
- Sponsor
- University of Washington
Hemorrhagic Shock, Peritonitis
Philadelphia Immediate Transport in Penetrating Trauma Trial
PIPT Trial (Philadelphia Immediate Transport in Penetrating Trauma Trial) A prospective randomized clinical trial comparing pre-hospital procedures to immediate transportation in patients with penetrating injury and shock.
- Trial name
- PIPT (NCT02821364)
- Testing
- Advanced Life Support
- Where
- United States
- Sponsor
- Temple University
Lymphoma, Follicular, Lymphoma, Small Lymphocytic
A Safety and Effectiveness Study of Vaccine Therapy in Patients With Indolent Lymphoma
Primary Objectives: To document the efficacy of treatment with autologous lymphoma-derived HSPPC-96 of selected patients with indolent lymphoma.
- Trial name
- NCT00081809
- Testing
- autologous human tumor-derived HSPPC-96
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Agenus Inc.
Sepsis, Septic Shock
Rotational Thromboelastometry Versus DIC Score in Sepsis
Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC).
- Trial name
- RODSS (NCT04610853)
- Testing
- rotational thromboelastometry
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Coagulation Dysfunction in Septic Shock, Hemodynamic Improvement Induced by Hydrocortisone
Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock.
- Trial name
- NCT02114710
- Testing
- Hydrocortisone
- Volunteers
- 240 people
- Sponsor
- Nanjing PLA General Hospital
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University