Clinical trials: Haemorrhagic Shock
Acute Coagulopathy
Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
The purpose of this study is to compare rapid thrombelastography (r-TEG) with conventional coagulation testing for diagnosing and treating coagulation abnormalities in severely injured patients who are likely to require…
- Trial name
- NCT01536496
- Testing
- Blood product transfusion based on conventional coagulation tests., Blood product transfusion based on rapid thrombelastography (r-TEG) results.
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Denver Health and Hospital Authority
Cytokine Release Syndrome, Neoplasms
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event
Background: Drugs or cell therapies to treat cancer can sometimes cause cytokine release syndrome (CRS). That is, the body makes too many cytokines after treatment. Cytokines are proteins that play a role in the immune system.
- Conditions
- Cytokine Release Syndrome, Neoplasms, Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Trial name
- NCT07499128
- Testing
- TempTraq, VitalTraq
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Cancer Institute (NCI)
Shock, Hemorrhagic, Injury Penetrating
Feasibility of Evaluating XSTAT Use in the Prehospital Setting
This study evaluates the prehospital use of the XSTAT device to control bleeding in junctional wounds. Participants will be randomized to the use of XSTAT versus standard care.
- Conditions
- Shock, Hemorrhagic, Injury Penetrating, Hemorrhage
- Trial name
- PhoXSTAT (NCT04663087)
- Testing
- XSTAT, Standard of Care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Hemorrhagic Shock
Blood Transfusion by Boston MedFlight Registry
The primary aim of this observational registry is to study the outcomes of patients with hemorrhagic shock transported by Boston MedFlight receiving blood products during transport.
- Trial name
- NCT04610814
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Relapsed/Refractory Multiple Myeloma (RRMM)
Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)
This study is researching whether the use of tocilizumab before the first dose of linvoseltamab will decrease the risk of Cytokine Release Syndrome (CRS) in participants who have Relapsed or Refractory Multiple Myeloma (RRMM) who…
- Trial name
- POPLIN (NCT07609940)
- Testing
- Linvoseltamab, Tocilizumab
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Regeneron Pharmaceuticals
Injury
Serum Vasopressin Levels and Severe Hemorrhagic Shock
The purpose of this study is to determine if vasopressin is used up by the body during traumatic shock (severe low blood pressure due to trauma).
- Trial name
- NCT01676454
- Where
- United States
- Sponsor
- Poudre Valley Health System
Septic Shock, Stroke Hemorrhagic
Oral Bedtime Melatonin in Critically Ill Patients
Oxidative stress is one of the main mechanisms causing harm in severe infection with septic shock, ischemia-reperfusion injury in resuscitated cardiac arrest and ischemic and hemorrhagic stroke.
- Conditions
- Septic Shock, Stroke Hemorrhagic, Strokes Thrombotic, Cardiac Arrest
- Trial name
- Mel-ICU (NCT06156059)
- Testing
- Oral Bedtime Melatonin
- Volunteers
- 160 people
- Sponsor
- Hospital San Carlos, Madrid
Hemorrhagic Shock, Pediatric Trauma
Effect of Resuscitation on Gastric Emptying Using POCUS in Pediatric Trauma Patients
Pediatric trauma often leads to hemorrhagic shock, which reduces blood flow to the digestive tract and delays gastric emptying. This delay can cause fluid and food to remain in the stomach, increasing the risk of pulmonary…
- Conditions
- Hemorrhagic Shock, Pediatric Trauma, Delayed Gastric Emptying, Gastric Dysmotility
- Trial name
- NCT07810907
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hemorrhagic Shock, Trauma Coagulopathy
The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study)
Background: Bleeding and coagulopathy still accounts for the majority of early in-hospital deaths following trauma. There have been lately several published studies suggesting that higher transfusion ratios of fresh frozen plasma…
- Trial name
- TRFL (NCT00945542)
- Testing
- Massive transfusion protocol, Standard of care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hemorrhage, Hemorrhagic Shock
Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock
This single-center, prospective, randomized controlled trial was approved by the institutional ethics committee and overseen by an independent data and safety monitoring board.
- Conditions
- Hemorrhage, Hemorrhagic Shock, Upper Gastrointestinal Bleeding (UGIB)
- Trial name
- NCT07129031
- Testing
- low-titer O-group whole blood, 1:1:1 component transfusion, ABO- and Rh-compatible whole blood
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital
Haemorrhagic Shock, Trauma Coagulopathy
Implementation of an Empiric Transfusion Bundle for Out of Hospital Patients With Haemorrhagic Shock
The investigators will evaluate the implementation of a treatment bundle (Fibrinogen, Plasma and Tranexamic Acid)
- Trial name
- C-TOP (NCT06891131)
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Dengue Fever
Role of Vitamin D in Prevention of Dengue Haemorrhagic Fever and Dengue Shock Syndrome
Dengue is an arthropod-borne disease, found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Unfortunately, there is no intervention available to stop dengue severity.
- Trial name
- NCT06071481
- Testing
- Arm-2 : 2,00,000 IU Vitamin D3 oral solution , Arm-3: 4,00,000 IU Vitamin D3 oral solution
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Trauma, Hemorrhage
Cold Stored Platelet in Hemorrhagic Shock
The Cold Stored Platelet Early Intervention in Hemorrhagic Shock (CriSP-HS) trial is a proposed 3 year, open label, multi-center, randomized trial designed to determine the feasibility, efficacy, and safety of urgent release cold…
- Trial name
- CriSP-HS (NCT04667468)
- Testing
- Cold Stored Platelets (CSP), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Jason Sperry
Hypofibrinogenemia, Hemorrhage
Cryo-FIRST: Effectiveness of INTERCEPT Fibrinogen Complex (IFC) for Trauma-Associated Hemorrhage
The objective of this multicenter, single-arm, observational study is to determine the feasibility and effectiveness of early administration of FDA-approved, pre-thawed Pathogen Reduced Cryoprecipitated Fibrinogen Complex…
- Conditions
- Hypofibrinogenemia, Hemorrhage, Trauma Associated Hemorrhage, Hemorrhagic Shock
- Trial name
- CRYO-FIRST (NCT07218185)
- Testing
- Pathogen Reduced Cryoprecipitated Fibrinogen Complex
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Cerus Corporation
Trauma, Trauma Injury
Whole Blood in Trauma Patients With Hemorrhagic Shock
This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs.
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple
- Trial name
- WEBSTER (NCT05634109)
- Testing
- Transfusion of blood products
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundacion Clinica Valle del Lili
Hemorrhagic Shock
Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Overall aim of this work is to evaluate new methods of resuscitation that can be applied by front-line responders on the battlefield, in civilian life, or which can be used during initial resuscitation in the first fixed facility…
- Trial name
- NCT01239680
- Testing
- Glutamine, Ringer's Lactate
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Missouri, Kansas City
Trauma, Multiple
Early Norepinephrine in Trauma Patients With Hemorrhagic Shock
The goal of this clinical trial is to learn if norepinephrine works to treat trauma patients with hemorrhagic shock. It will also learn about the safety of norepinephrine.
- Trial name
- ENTHeS (NCT06977659)
- Testing
- Norepinephrine
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- Visarat Palitnonkiat
Sepsis, Bleeding Disorder
Role of Thromboelastography in Septic Shock
Coagulation dysfunction is frequent in septic patients and it is associated with an increase risk of mortality. During sepsis platelets number usually decreases and their function is reduced and this mechanism is sustained by an…
- Trial name
- NCT03095625
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Turin, Italy
Shock,Hemorrhagic
A Study to Evaluate the Safety and Tolerability of Valproic Acid in Healthy Volunteers (Part 1)
The purpose of the first part of this study is to determine the safety and tolerability of ascending doses of valproic acid (also known as Depacon) administered as intravenous infusion (IV) in doses ranging from 15 mg/kg to 250…
- Trial name
- NCT01951560
- Testing
- Valproic Acid, Isotonic saline solution
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Dr. Hasan Alam
Norepinephrine, Hemorrhagic Shock
Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock
The aim of this work was to investigate the effects of low dose of norepinephrine in preperiod of hypotensive resuscitation in hemorrhagic shock.
- Conditions
- Norepinephrine, Hemorrhagic Shock, Hypotensive Resuscitation
- Trial name
- NCT06311903
- Testing
- Low dose of Norepinephrine (NE), High dose of Norepinephrine (NE)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Tanta University