Clinical trials: Hallucinations
Schizophrenia
Effect of Repetitive Transcranial Magnetic Stimulation on Resting State Brain Activity in Schizophrenia
This study compares the efficacy of low and high frequency repetitive transcranial magnetic stimulation (rTMS) as a means of treating subjects with schizophrenia. Magnetic pulses delivered over the scalp cause brain activity.
- Trial name
- NCT01620086
- Testing
- Active Repetitive Transcranial Magnetic Stimulation 1 Hz, Active Repetitive Transcranial Magnetic Stimulation 10 Hz, Active control site Repetitive Transcranial Magnetic Stimulation at 1Hz
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Lewy Body Disease, Lewy Body Dementia
Visual Hallucinations in Lewy Body Diseases
The goal of this basic experimental study involving humans (BESH) protocol is to improve the understanding of neural mechanisms underlying visual hallucinations in Lewy Body diseases to inform future treatment developments.
- Conditions
- Lewy Body Disease, Lewy Body Dementia, Parkinson Disease, Parkinson Disease Dementia
- Trial name
- NCT07849413
- Testing
- Behavioral Tasks, MRI/MEG Scans
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Parkinson's Hallucinations, Dementia With Lewy Bodies
Trial of Ondansetron as a Parkinson's HAllucinations Treatment
TOPHAT (Trial of Ondansetron as a Parkinson's HAllucinations Treatment) is a double blind, individually randomized, placebo-controlled, parallel group, flexible dose trial of ondansetron (8-24mg/day) as a treatment for…
- Trial name
- TOP HAT (NCT04167813)
- Where
- 23 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University College, London
Treatment Resistant Schizophrenia
Reduction of Auditory-Verbal Hallucinations in Schizophrenia Through Cortical Neuromodulation
Approximately 1% of the general population will be affected by schizophrenia over the course of their lives, with life expectancy being reduced by 20 years on average and quality of life being severely diminished in affected…
- Trial name
- HALLUSTIM (NCT06361160)
- Testing
- Active Transcranial Magnetic Stimulation (TMS)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia, Schizo Affective Disorder
Models of Auditory Hallucination
The purpose of this study is to address the shortcoming in clinical hallucination research by causally manipulating the neural loci of conditioned hallucination task behavior in-person in patients with psychosis using…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Auditory Hallucination
- Trial name
- NCT04210557
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Auditory Hallucinations in Patients With Schizophrenic Disorders
High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Schizophrenia : a Randomized Controlled Study
Background: Repetitive transcranial magnetic stimulation (rTMS) is a recent therapeutic which has demonstrated its efficacy in the treatment of auditory hallucinations in patients with schizophrenic disorders.
- Trial name
- TMS-Hz (NCT01022489)
- Testing
- Transcranial magnetic stimulation: rTMS
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Caen
Hallucinations, No Hallucinations
Understanding Hallucinations (Part I)
Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population.
- Trial name
- UH-1 (NCT01907568)
- Where
- 4 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Auditory Hallucinations
The Physalis Child : Identification of Cognitive and Emotional Factors
The aim of this study is to show presence of cognitive and emotional factors on the beginning and persistence of auditory hallucinations in non-psychotic children.
- Trial name
- NCT02567500
- Testing
- Patients with auditory hallucination, Patients without auditory hallucination
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Lenval
Hallucinations, Auditory, Schizophrenia Spectrum and Other Psychotic Disorders
VR-based Avatar Therapy for Treatment of Auditory Hallucinations
The primary aim of this study is to evaluate the safety and efficacy of AVATAR therapy, developed to address residual auditory hallucinations persisting despite medication in schizophrenia spectrum disorder.
- Trial name
- NCT06505564
- Testing
- AVATAR therapy
- Where
- 4 sites in Hungary, Poland and 1 more
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Parkinson Disease
Pimavanserin for Sleep in Parkinson Disease
This pilot, self-control study is for patients with Parkinson's Disease (PD) psychosis (e.g., visual hallucinations, delusions) and sleep problems.
- Trial name
- NCT05796167
- Testing
- Pimavanserin
- Where
- United States
- Sponsor
- State University of New York - Downstate Medical Center
Schizophrenia Spectrum and Other Psychotic Disorders, Hallucinations, Auditory
Multi-dimensional Investigations of Negative Emotions and Drug-resistant Auditory Verbal Hallucinations in Psychosis
Auditory verbal hallucinations (AVH) are commonly reported as source of distress, disability and mortality in schizophrenia. Despite proven efficacy of antipsychotics, many patients still experience drug-refractory AVH.
- Trial name
- NCT03449407
- Where
- Hong Kong
- Volunteers
- 47 people
- Sponsor
- Chinese University of Hong Kong
Schizophrenia
Low and High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Resistant Auditory Hallucination in Schizophrenia
Auditory Hallucinations (AH) are experienced by 50 to 70% of subjects with schizophrenia. Almost a quarter of patients are medication resistant to such symptoms.
- Trial name
- rTMS (NCT02175251)
- Testing
- high frequency (20Hz), low frequency (1Hz)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Schizophrenia
tDCS & Auditory Hallucinations in Schizophrenia
The aim of this study is to evaluate tDCS effects on schizophrenia symptoms, particularly on auditory verbal hallucinations. tDCS applied with cathodal (inhibitory) electrode over the left temporal parietal junction and anodal…
- Trial name
- NCT02227563
- Testing
- Active tDCS, control
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Herzog Hospital
Auditory Hallucinations
CHALLENGE. A Randomised Clinical Trial Examining Virtual Reality Therapy
The study is a randomised, assessor-blinded parallel-groups superiority clinical trial, allocating a total of 266 patients to either the experimental intervention or standard intervention.
- Trial name
- NCT04661163
- Testing
- Psychotherapy
- Where
- Denmark
- Volunteers
- 270 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Schizophrenic Disorders
Interest of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Auditory Hallucinations
Auditory hallucinations are common (present in 60-70% of cases) and extremely debilitating. Behavioral disorders associated with them can have serious social repercussions.
- Trial name
- TMS HALLU (NCT02525315)
- Testing
- Transcranial magnetic stimulation: rTMS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Schizophrenia, Schizo Affective Disorder
Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia.
- Trial name
- NCT05343598
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mclean Hospital
Lewy Body Dementia
Diagnostic of Lewy Body Dementia by Combining Scintigraphy (SPECT) Using a Specific Transporter and Magnetic Resonance Imaging (MRI)
The aim of this study is to improve the diagnostic of Lewy body dementia by combining the scintigraphy (SPECT) usig a spécific transporter and magnetic resonance imaging (MRI).
- Trial name
- DatScan (NCT00820937)
- Testing
- Single photon emission computed tomography and Magnetic Resonance Imaging
- Where
- 3 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Limoges
Auditory Hallucinations
Transcranial Magnetic Stimulation (TMS) for Treatment of Auditory Hallucinations
Transcranial magnetic stimulation (TMS) involves the use of magnetic fields to non-invasively stimulate the brain. Studies overseas have suggested this may be an effective and safe treatment for auditory hallucinations in…
- Trial name
- NCT00763841
- Testing
- Transcranial magnetic stimulation
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- The University of New South Wales
Lewy Body Dementia, Dementia With Lewy Bodies
Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder
This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia…
- Conditions
- Lewy Body Dementia, Dementia With Lewy Bodies, Parkinson's Disease Dementia, Visual Hallucinations
- Trial name
- NCT02871427
- Testing
- Nelotanserin
- Where
- 19 sites in United States
- Volunteers
- 80 people
- Sponsor
- Axovant Sciences Ltd.
Schizophrenia
rTMS for Auditory Hallucinations Guided by Magnetoencephalography
rTMS and MEG for auditory hallucinations via self controlled clinical trials. Repetitive transcranial magnetic stimulation (rTMS) can increase or decrease cortical excitability in patients with psychosis (such as schizophrenia).
- Trial name
- NCT05598450
- Testing
- rTMS and MEG for auditory hallucinations via self controlled clinical trials
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center