Clinical trials: Hard of Hearing
Hearing Loss
A Comparison of a Currently Marketed Hearing Aid Programmed With Two Different Fitting Methods
This study is designed to investigate the benefits of the hearing aid in the laboratory and in daily life when fitted with two different methods. Subjective and objective evaluations will be made.
- Trial name
- NCT03498274
- Testing
- Fitting System, Traditional Fitting System
- Where
- 2 sites in Switzerland
- Volunteers
- 14 people
- Sponsor
- Bernafon AG
Hearing Loss
Wind Noise Sound Quality Preference and Claims Study
Claims evidence is required for a new Wind Noise Canceller (WNC) algorithm. Wind noise is not sound in the classic sense, as it does not correspond to pressure waves moving through the air.
- Trial name
- WB (NCT07543770)
- Testing
- New wind noise canceller, Old wind noise canceller
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Jonathan Vaisberg
Hearing Loss
Quality Control of CE-Certified Phonak Hearing Aids - 2020_43
Phonak Hearing Systems pass through different development and study stages. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT04723173
- Testing
- Feature for noise reduction (on), Feature for noise reduction (off)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Sonova AG
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations
This study is a multicenter, single-arm, open-label Phase I/II clinical trial, which is designed to evaluate the safety, tolerability and efficacy of EHT102 injection in treating congenital hearing loss secondary to biallelic…
- Trial name
- NCT07288580
- Testing
- EHT102 Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Euhearing Therapeutics Co., Ltd
Tinnitus, Bilateral, Cochlear Synaptopathy
A Study Testing Safety and Efficacy of Transtympanic Paliroden for the Treatment of Cochlear Synaptopathy in Participants With Chronic, Constant Tinnitus
The goal of this clinical trial is to investigate if paliroden (CIL001) is safe and can help treat cochlear synaptopathy in adult participants 18-75 years of age with normal hearing thresholds and normal cognition who exhibit…
- Trial name
- REACT (NCT07826507)
- Testing
- paliroden (CIL001)
- Volunteers
- 60 people
- Sponsor
- Cilcare SAS
Hearing Loss
The RW-Precision-Coupler Clinical Investigation
The RW-Precision-Coupler Clinical Investigation is prospective, non-randomized, open label, single subjects repeated measures, longitudinal monocentric trial.
- Trial name
- NCT04890145
- Testing
- RW-Precision-Coupler
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Ototoxicity
Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment
The purpose of this study is to evaluate whether DB-020 administered via an injection in the middle ear prevents hearing loss in participants who will receive high doses of cisplatin as part of their treatment for cancer.
- Trial name
- NCT04262336
- Testing
- DB-020
- Where
- 8 sites in United States, Australia
- Volunteers
- 22 people
- Sponsor
- Decibel Therapeutics
Meniere's Disease
OTO-104 for the Treatment of Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- NCT01412177
- Testing
- OTO-104
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Otonomy, Inc.
Sensorineural Hearing Loss, Bilateral
Study of Music and Speech Perception in New Cochlear Implanted Subjects Using or Not a Tonotopy Based Fitting
Main objective: Show the superiority of tonotopy based fitting strategy compared to default fitting strategy on the perception speech in noise.
- Trial name
- NCT04922619
- Testing
- tonotopy based fitting then default fitting, default fitting then tonotopy based fitting
- Where
- France
- Volunteers
- 26 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
High Frequency Sensorineural Hearing Loss
Hybrid L24 New Enrollment Post Approval Study
This study evaluates the long term safety and effectiveness of the Nucleus Hybrid L24 Implant in a group of newly implanted adults.
- Trial name
- HNE (NCT02379819)
- Testing
- Nucleus Hybrid L24 Implant
- Where
- 19 sites in United States
- Volunteers
- 52 people
- Sponsor
- Cochlear
Severe to Profound Hearing Loss
Retrospective Analysis of Performance and Safety of MED-EL Cochlear Implants.
This study is a single center, non-interventional, retrospective, post-market observational study. Data will be extracted retrospectively from the local clinical database of the site and will be fully anonymized.
- Trial name
- BELPS (NCT07777562)
- Testing
- Cochlear implantation
- Where
- Switzerland
- Volunteers
- 700 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Hearing Loss
Safety and Efficacy of a Drug Eluting Slim Modiolar Electrode Array
This clinical study will test a new type of cochlear implant known as CI632D. This experimental cochlear implant has been designed to slowly release a drug called dexamethasone.
- Trial name
- DEE-REX (NCT06598059)
- Testing
- Cochlear implant, Dexamethasone
- Where
- 11 sites in United States
- Volunteers
- 56 people
- Sponsor
- Cochlear
Cochlear Hearing Loss
Safety and Performance of HiRes Ultra/Ultra 3D Cl Mid-Scala Electrodes in Adults With Severe-to-profound Hearing Loss
This is a prospective study designed to evaluate the safety and performance of the HiRes Ultra Cl HiFocus MS Electrode and HiRes Ultra 3D Cl HiFocus MS Electrode (Ultra X) under normal conditions of use as it is approved for this…
- Trial name
- NCT04610112
- Testing
- Cochlear implantation
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Advanced Bionics AG
Hearing Loss
Hearing Aid Education and Adaptation System
This RCT will have two arms: A control group that receives the standard of care from audiologists and an experimental group that receives both the standard of care and the at-home use of the TELLYHealth intervention.
- Trial name
- NCT02839759
- Testing
- TELLYHealth
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Healthcare Technologies and Methods, LLC
Hearing Loss, Sensorineural, Noise Induced Hearing Loss
FX-322 in Adults With Acquired Sensorineural Hearing Loss
This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, single-dose, multicenter study to evaluate the efficacy of FX-322, administered by intratympanic injection, in adults with acquired sensorineural…
- Conditions
- Hearing Loss, Sensorineural, Noise Induced Hearing Loss, Sudden Hearing Loss
- Trial name
- NCT05086276
- Testing
- FX-322
- Where
- 26 sites in United States
- Volunteers
- 142 people
- Sponsor
- Frequency Therapeutics
DFNB9
An Investigator Initiated Study for OTOV101N+OTOV101C Injection
This study is an investigator initiated study to evaluate the safety, tolerability, and efficacy of OTOV101N+OTOV101C injection in treating patients with OTOF mutation-related deafness.
- Trial name
- NCT05901480
- Testing
- OTOV101N+OTOV101C Injections
- Where
- 23 sites in China
- Volunteers
- 25 people
- Sponsor
- Otovia Therapeutics
Hearing Loss, Bilateral Sensorineural, Progressive
Quality Control of CE-Certified Phonak Hearing Aids - 2017_27
A methodical evaluation of new CE-labelled Phonak Hearing Systems is intended to be conducted on hard of participants with a hearing loss to grant quality control prior to product launch.
- Trial name
- NCT03253003
- Testing
- Line extension of the Phonak Audéo B product family
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- Sonova AG
Nephritis, Hereditary, Hematuria-Nephropathy-Deafness Syndrome
Biomarker for Alport Syndrome (BioAlport)
International, multicenter, observational, longitudinal monitoring study to identify biomarker/s for Alport syndrome and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s
- Trial name
- BioAlport (NCT02718027)
- Where
- 7 sites in Albania, Georgia and 5 more
- Volunteers
- 12 people
- Sponsor
- CENTOGENE GmbH Rostock
Hearing Loss, Sensorineural, Cochlear Implantation
Comparison of Performance Using MED-EL Automatic Sound Management
This study will evaluate the speech perception ability of adult cochlear implant users in background noise using various MED-EL Automatic Sound Management (ASM) features.
- Trial name
- NCT07500311
- Testing
- Automatic Sound Management Fixed Directionality, Automatic Sound Management Adaptive, Omnidirectional Settings
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Med-El Corporation
Delayed Graft Function
Study on Delayed Graft Function Using Paired Kidneys
The study is designed to evaluate the safety and efficacy of an intravenously administered drug in recipients of kidneys from cardiac death donors who are risk for developing delayed graft function.
- Trial name
- NCT01561599
- Testing
- BB3, Normal Saline
- Where
- 3 sites in Netherlands, Spain and 1 more
- Volunteers
- 12 people
- Sponsor
- Angion Biomedica Corp