Clinical trials: Hashimoto
Undefined
Single Ascending-dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male Adult Subjects
Double-blind, placebo-controlled, First-in-Human, single ascending-dose study. Approximately 40 healthy adult male subjects will be given a single capsule of MYMD1 to determine its safety, how well it is tolerated, how the body…
- Trial name
- NCT04349761
- Testing
- MyMD1
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TNF Pharmaceuticals, Inc.
Autoimmune Thyroiditis
Low Level Laser Therapy for Autoimmune Thyroiditis
INTRODUCTION: Chronic autoimmune thyroiditis (TCA) is the main cause of acquired hypothyroidism, which requires continuous treatment with levothyroxine (LT4).
- Trial name
- NCT02240563
- Testing
- Low-level laser therapy, Non laser ordinary red light
- Where
- 2 sites in Brazil
- Volunteers
- 43 people
- Sponsor
- University of Sao Paulo General Hospital
Thyroid Eye Disease, Graves Orbitopathy
A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)
The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twice daily (BID) vs.
- Conditions
- Thyroid Eye Disease, Graves Orbitopathy, Endocrine System Diseases, Eye Diseases
- Trial name
- LIDS (NCT05276063)
- Testing
- Linsitinib
- Where
- 30 sites in United States, Canada and 3 more
- Volunteers
- 90 people
- Sponsor
- Sling Therapeutics, Inc.
Autoimmune Thyroiditis, Hashimotos Thyroiditis
Selenium Treatment in Autoimmune Thyroiditis (AIT)
Selenium suppresses autoimmune destruction of thyrocytes and decreases titers of serum TPOAb in AIT patients. Older 4 clinical trials approved the efficacy of the daily dose of 200micg.
- Trial name
- NCT00271427
- Testing
- L-Selenomethionine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ege University
Autoimmune Thyroiditis
A Study of Selenomethionine and Myo-inositol(SOLOWAYS_TM) in Patients With Autoimmune Thyroiditis Carrying the DIO2 Thr92Ala Polymorphism
This pilot, genotype-stratified clinical trial aims to evaluate the safety and preliminary efficacy of combined selenomethionine and myo-inositol supplementation in patients with autoimmune thyroiditis (AIT), including…
- Trial name
- NCT06867913
- Testing
- Supplement groupx
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Autoimmune Thyroiditis, Recurrent Miscarriage
Thyroid Hormone Values and Anti-thyroid Peroxidase Antibody Positivity in Recurrent Pregnancy Loss
The aim of this study is to compare the thyroid hormone values and anti-thyroid peroxidase (anti-TPO) levels of women with a diagnosis of recurrent pregnancy loss (RPL) and healthy pregnancies.
- Trial name
- NCT05680376
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Zonguldak Bulent Ecevit University
Hypothyroidism, Subclinical Hypothyroidism
Thyroid Disorders in Malaysia: A Nationwide Multicentre Study
This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine…
- Conditions
- Hypothyroidism, Subclinical Hypothyroidism, Hyperthyroidism, Subclinical Hyperthyroidism
- Trial name
- MyEndo-Thyroid (NCT02190214)
- Volunteers
- 2,498 people, healthy volunteers welcome
- Sponsor
- International Islamic University Malaysia
Type 1 Diabetes, Autoimmune Diseases
Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-up
This study aims to describe the prevalence of additional autoimmune diseases and their specific antibodies at type 1 diabetes (T1D) diagnosis, and their incidence rate during follow-up, for children and adolescents.
- Conditions
- Type 1 Diabetes, Autoimmune Diseases, Hashimoto Disease, Graves Disease
- Trial name
- AADT1D (NCT04789993)
- Testing
- No intervention.
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Autoimmune Thyroiditis
Oxidative Status in Children With Autoimmune Thyroiditis
Oxidative status in autoimmune thyroiditis was not investigated previously in children and adolescents. We investigated oxidant and antioxidant systems in a cohort of Egyptian children and adolescents with AIT to explore their…
- Trial name
- NCT02318160
- Testing
- measurement of oxidant status in AIT
- Volunteers
- 64 people
- Sponsor
- Assiut University
Thyroiditis, Autoimmune
Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)
This is a study to evaluate the safety, tolerability, and potential effects of Anatabloc dietary supplementation on antithyroid autoantibodies, thyroid structure, and thyroid function in subjects with autoimmune thyroiditis.
- Trial name
- ASAP (NCT01551498)
- Testing
- Anatabloc Supplement
- Where
- 9 sites in United States
- Volunteers
- 165 people
- Sponsor
- Rock Creek Pharmaceuticals, Inc.
Hashimoto Disease
Single Ascending and Multiple Dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male and Female Adult Subjects
Double-blind, placebo-controlled, single ascending and multiple dose study. Approximately 32 healthy adult male and female subjects will be given a single capsule of MYMD1 to determine its safety, tolerability, and…
- Trial name
- NCT05077865
- Testing
- MYMD-1
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TNF Pharmaceuticals, Inc.
Hashimoto Disease, Psoriasis
Metabolic Biomarkers in Hashimoto's Thyroiditis and Psoriasis
Hashimoto's disease (HT) and psoriasis (PsO) have a significant impact on patient's quality of everyday life, and early diagnosis is critical for the symptoms management and prognosis.
- Trial name
- METHAP (NCT04693936)
- Testing
- Nutraceutical Combination Plan
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Crete
Graves Ophthalmopathy, Graves Disease
Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy
The study is aimed at assessing IGF-1R-Abs in patients with Graves' disease, with or without GO, compared with healthy subjects and patients with autoimmune thyroiditis in a cross-sectional investigation.
- Conditions
- Graves Ophthalmopathy, Graves Disease, Autoimmune Thyroiditis
- Trial name
- IGF1RAbsGO (NCT03498417)
- Testing
- Serum antibodies against the IGF-1R
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Thyroiditis Autoimmune
Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT
Over the past 10 years, several clinical studies have suggested that selenium supplementation may influence the natural history of AIT.
- Trial name
- NCT02302768
- Testing
- Selenomethionine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Siena
Autoimmune Thyroiditis
Dysregulation of the Soluble α-Klotho-FGF23 Axis in Hashimoto's Thyroiditis: A Case-Control Study
Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease and is increasingly recognized as a condition associated with chronic low-grade systemic inflammation beyond thyroid hormone dysfunction.
- Trial name
- klofgfhashi (NCT07453290)
- Testing
- Blood Sampling and Biomarker Measurement
- Volunteers
- 150 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Autoimmune Thyroiditis
Gluten-free Diet in Women With Autoimmune Thyroiditis
The purpose of this interventional study was to check if the elimination of gluten from the diet of women with autoimmune thyroiditis affects their health and thyroid function, quality of life, and the gut microbiome composition.
- Trial name
- NCT06249074
- Testing
- Gluten-free diet, Gluten capsules supplementation
- Where
- Poland
- Volunteers
- 31 people
- Sponsor
- Medical University of Gdansk
Hashimoto Thyroiditis
The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis
Hashimoto's thyroiditis is an autoimmune thyroid disease, which induced chronic inflammation of thyroid gland and destroys thyroid tissue.
- Trial name
- NCT01760421
- Testing
- Hydroxychloroquine
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Hashimoto Disease, Treatment Levothyroxine
Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
The objective of this study is to evaluate the effect of vitamin D supplementation on thyroid autoimmunity, thyroid function, and other metabolic and clinical variables associated with the thyroid axis in patients with…
- Conditions
- Hashimoto Disease, Treatment Levothyroxine, Vitamin D Deficiency
- Trial name
- NCT04778865
- Testing
- Vitamin D-correction, Vitamin D-RDA
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Infertility, Autoimmune Thyroiditis
The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis
The aim of the work is to determine whether the use of immunomodulatory drugs could improve the reproductive of outcome of infertile patients who have autoimmune thyroiditis with positive autoimmune antibodies undergoing IVF-ET.
- Trial name
- NCT03289403
- Testing
- Immunomodulatory, Thyroxine
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Aljazeera Hospital
Thyroid Autoimmune Disease, Hashimoto's Thyroiditis
Impact of Restrictive Diets on Inflammation and Quality of Life in Autoimmune Thyroiditis
The purpose of this clinical trial is to evaluate whether a dietary intervention can improve clinical and immunological outcomes in women with autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis and Graves'…
- Conditions
- Thyroid Autoimmune Disease, Hashimoto's Thyroiditis, Graves Disease
- Trial name
- TAILOR (NCT07879690)
- Testing
- Gluten-free, casein-free, low-glycemic-index diet
- Where
- Andorra
- Volunteers
- 60 people
- Sponsor
- University of Barcelona