Clinical trials: Head
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma (HNSCC)
Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and Neck Cancer
Avmacol is an over-the-counter dietary supplement containing broccoli seed and sprout extracts in tablet form, hypothesized to activate protective cellular pathways including detoxication.
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma (HNSCC), Head and Neck Carcinoma, Head and Neck
- Trial name
- NCT03268993
- Testing
- Avmacol
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Thyroid Cancer
Mapping Patient Decision-making in Thyroid Cancer
The incidence of thyroid cancer has exploded in the past 5 decades, with a roughly three-fold increase since 1995. Fortunately, many new cases are small, early-stage thyroid cancers.
- Trial name
- NCT06411834
- Testing
- Decision navigation tool
- Volunteers
- 50 people
- Sponsor
- University of California, Los Angeles
Head and Neck Cancer
Skin Changes in Head and Neck Cancer During Immuno-(Chemo-) And Radiotherapy With Erbitux® (HICARE)
This is a national multicenter phase IV study to assess acute radiation dermatitis of combined radioimmuno(chemo)therapy with Cetuximab in patients with locally advanced, non-metastatic squamous cell carcinoma of the head and…
- Trial name
- HICARE (NCT01553032)
- Testing
- Erbitux®, Fractionated Radiotherapy
- Where
- Germany
- Volunteers
- 139 people
- Sponsor
- University of Heidelberg Medical Center
Esophageal Cancer
Organ-Preserving Endoscopic Resection & Adjuvant RADIO-immuno-chemotherapy for Esophageal Cancer
The goal of this study is to assess the safety of delivering concurrent adjuvant chemoradiation or immuno-radiation therapy after EMR/ESD in pT1b/T2N0 esophageal cancer patients. The main objectives of the study are: 1.
- Trial name
- OPERARADIO (NCT05667298)
- Testing
- Adjuvant Immunoradiotherapy (ARM1) and Adjuvant Immunotherapy (ARM1B), Adjuvant chemoradiotherapy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Manitoba
Recurrent or Metastatic Salivary Gland Cancer of the Head and Neck
Trial of BIBF1120 (Nintedanib) in Patients With Recurrent or Metastatic Salivary Gland Cancer of the Head and Neck
Recently, sorafenib which can target VEGFR and PDGFR demonstrated 13-16% of response rate in patients with recurrent/metastatic salivary gland cancers, suggesting that VEGFR and PDGFR might be important role in salivary gland…
- Trial name
- NCT02558387
- Testing
- BIBF1120
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Laryngectomy
Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing
using zinc and probiotics supplementation for providing better prognosis for laryngeal cancer patients under going total or partial laryngectomy.
- Trial name
- NCT06674564
- Testing
- Zinc Acetate 50 Mg Oral Capsule, Probiotic
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Esophageal Squamous Cell Carcinoma
Radiotherapy Plus Durvalumab in Elderly Esophageal Squamous Cell Carcinoma
The incidence and mortality of esophageal cancer are at the forefront in China, among which the elderly patients account for a large proportion.
- Trial name
- NCT04851132
- Testing
- Radiotherapy, Durvalumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Chinese Academy of Medical Sciences
Thyroid Cancer
RET Inhibitor for Neoadjuvant Therapy in Locally Advanced RET-altered Thyroid Cancer
This study is a multicenter observational study. Patients receive neoadjuvant therapy with RET inhibitors in the real world, and those who can undergo surgery after neoadjuvant therapy receive surgical treatment.
- Trial name
- NCT06530316
- Testing
- RET Inhibitor, Surgery
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Fudan University
Esophageal Cancer
Endoscopic Assisted Calcium Electroporation in Esophageal Cancer
In this pilot study, patients with non-curable esophageal cancer will be treated with endoscopic assisted calcium electroporation (CaEP).
- Trial name
- NCT04958044
- Testing
- Calcium Gluconate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Michael Patrick Achiam
Head & Neck Cancer
Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck Cancer
The purpose of this study is to evaluate the diagnostic performance of 18F-FDG micro-PET-CT in malignant Head and neck cancer compared to definitive histological analysis (gold standard).
- Trial name
- TEP Margins (NCT07285564)
- Testing
- micro PET/CT
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Henri Becquerel
Cancer of Head and Neck
Prognostic Value of 18FDG PET/CT Textural Indices in HNSCC
Head and neck (HN) cancer is the sixth most common malignancy worldwide, with around 800,000 new cases and 320,000 deaths in 2015.
- Trial name
- ImpactTextureO (NCT03378193)
- Where
- France
- Volunteers
- 284 people
- Sponsor
- University Hospital, Brest
Thyroid Cancer
Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer
The purpose of this study is to determine the effectiveness of two anticancer drugs, everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer responding to treatment with radioiodine or where it is…
- Trial name
- NCT01270321
- Testing
- Everolimus, Pasireotide, Everolimus and Pasireotide
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Emory University
Esophageal Cancer
A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study
The purpose of this study is to investigate the effects of the addition of the stereotactic body radiotherapy and durvalumab to a well tolerated 2 week chemotherapy and radiation treatment regimen in people with esophageal cancer…
- Trial name
- PALEO (NCT06290505)
- Testing
- Durvalumab
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 54 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Head and Neck Cancer
A Study of Chemoradiotherapy for Intermediate Stage/Selected Stage IV Cancers of the Head and Neck
The primary objective of the study is to evaluate time to progression in eligible patients with cancer of the oral cavity, pharynx, larynx, paranasal sinuses, and cervical esophagus when treated with the concomitant…
- Trial name
- NCT00203905
- Testing
- 5-Fluorouracil, Hydroxyurea-[FHX], Bevacizumab, 5-Fluorouracil, Hydroxyurea-[FHX]
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Chicago
Hypopharyngeal Carcinoma, Laryngeal Carcinoma
Interest of MRI in Preoperative Staging for the Laryngeal and Hypopharyngeal Cancer
To determine if MRI can detect preoperative invasion of cartilage by laryngeal and hypopharyngeal carcinoma, and to compare it to CT imaging and histopathology in excised larynges and/or hypopharynges.
- Trial name
- Larynx MRI (NCT03132727)
- Testing
- Pharyngo laryngeal MRI
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Hospices Civils de Lyon
Esophageal Cancer, Esophageal Dysplasia
Comparison of O-type Hybrid Knife and IT Knife in ESD
By combining injection and dissection capability together, O-type Hybrid knife could possibly shorten the endoscopic submucosal dissection procedure for upper gastrointestinal neoplasms.
- Conditions
- Esophageal Cancer, Esophageal Dysplasia, Stomach Cancer, Stomach Dysplasia
- Trial name
- NCT01760070
- Testing
- Hybrid knife, IT knife
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Liver Metastasis, Pelvic Cancer
Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors
This multi-center photodynamic therapy study plans to treat patients with large tumors in any superficial location, sarcoma, tumors of oral/oro-pharyngeal cavity, tumors with extensive pelvic involvement, or liver metastasis.
- Conditions
- Liver Metastasis, Pelvic Cancer, Head and Neck Cancer, Sarcoma
- Trial name
- NCT00028405
- Testing
- LS 11(Taporfin Sodium), Lumaflex Light Delivery Catheter
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Light Sciences LLC
Adenocarcinoma of Head of Pancreas
Neoadjuvant Folfirinox Followed by Capecitabine and Limited Field Radiation for Localized Pancreatic Head Adenocarcinoma
This study is for subjects with adenocarcinoma of the pancreas. The purpose of this research study is to determine the safety and effectiveness of modified Folfirinox and radiation therapy as treatment for adenocarcinoma (cancer)…
- Trial name
- NCT01677988
- Testing
- Neo-adjuvant Chemotherapy, Chemoradiation, Surgical Resection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical University of South Carolina
Esophageal Diseases, Esophagus SCC
Cytosponge™ Feasibility Study in Tanzania
A Tanzanian pilot study to test the feasibility of using the Cytosponge™ device - a less-invasive endoscopy alternative - for research on esophageal squamous cell carcinoma in African settings.
- Trial name
- CytoSCCAPE (NCT04090554)
- Testing
- Cytosponge™
- Where
- Tanzania
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer