Clinical trials: Head Trauma
Hematoma, Subdural, Chronic
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes.
- Trial name
- NCT05426889
- Testing
- subdural hematoma burr hole drainage, drug conservative treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Skull Base
Bed Rest Duration and Outcomes in Endoscopic Skull Base Reconstruction
This study is a randomized controlled trial conducted across multiple centers. Due to the anatomical and pathological complexity of endoscopic endonasal skull base surgery, the study scope was restricted to the midline anterior…
- Trial name
- BRO (NCT07465861)
- Testing
- non-bed-rest, 2-day bed-rest, 1-day bed-rest
- Volunteers
- 316 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Traumatic Brain Injury
Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation
To learn more about behavior and everyday functioning after brain injury, and to learn if behavior and functioning gets better with more education about changes after brain injury.
- Trial name
- NCT00205569
- Testing
- First Steps Educational Curriculum
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Virginia Commonwealth University
Anterior Cruciate Ligament Injuries, Concussion, Brain
Making Football Safer for Women: Implementing an Injury Prevention Program
The aim of this study is to determine how we can best support coaches to implement an injury prevention (IP) program (Prep-to-Play) in female community Australian Football.
- Conditions
- Anterior Cruciate Ligament Injuries, Concussion, Brain, Musculoskeletal Injury
- Trial name
- Prep-to-Play (NCT04856241)
- Testing
- Coaching, Peer support, Educational materials
- Where
- Australia
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- La Trobe University
Brain Injuries, Traumatic
HITT Device Pilot Testing for Traumatic Brain Injury
The purpose of this research study is to collect data from the eyes of traumatic brain injury (TBI) patients. Patients will look at a green target that will measure the fixation of the eye for 30 seconds.
- Trial name
- NCT03249818
- Testing
- HITT device
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rebiscan, Inc.
Post Traumatic Stress Disorder, Traumatic Brain Injury
TMS-fNIRS Personalized Dosing
The intent of this study is to establish technical feasibility in a clinical population (PTSD, with or without mild TBI) of personalized TMS-fNIRS technology.
- Trial name
- NCT05916417
- Testing
- TMS-fNIRS over the dl-PFC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Brain Injury
Intermediate Size Patient Population Expanded Access Protocol to Evaluate HB-adMSCs for the Treatment of Patients With Traumatic or Nontraumatic Brain Injury
This expanded access protocol is part of IND 031942 to evaluate efficacy and safety of multiple intravenous administrations of allogeneic HB-adMSCs for the treatment of nontraumatic or traumatic brain injury for up to 8 patients…
- Trial name
- NCT07164482
- Testing
- HB- adMSCs (Hope Biosciences adipose derived mesenchymal stem cells)
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Brain Injury
The Effects of Mindfulness Based Stress Reduction on Patients With Traumatic Brain Injury
This study is studying the effects of Mindfulness Based Stress Reduction (MBSR), a standard protocol of gentle yoga and breath meditation, on patients with Traumatic Brain Injury (TBI).
- Conditions
- Traumatic Brain Injury, Brain Injury, Stress
- Trial name
- NCT01613872
- Testing
- Mindfulness Based Stress Reduction
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Blow-Out Fractures, Orbital Fractures
Accuracy& Orbital Volume Using Patient Specific Titanium Implant Vs Zirconia for Orbital Floor Reconstruction
Comparative study used to assess if the patient specific zirconia implant will provide better accuracy, intraoperative adaptability, precise orbital volume and soft tissue reaction with more cost effectiveness than the patient…
- Conditions
- Blow-Out Fractures, Orbital Fractures, Orbital Floor Fracture, Orbital Trauma
- Trial name
- NCT06369129
- Testing
- Orbital floor reconstruction with Patient Specific Zirconia Implant, Orbital floor reconstruction with Patient Specific Titanium Implant
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Brain Concussion
Effects of Neuromuscular Training on EEG Adaptations in Young Athletes
The purpose of the current project is to determine the effects of augmented neuromuscular training on brain neuroplasticity. Specifically we aim to evaluate the potential of augmented NMT (aNMT) to alter brain neural performance…
- Trial name
- NCT03913975
- Testing
- Neuromuscular training
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acquired Brain Injury, Dysphagia
Local Vibration in Patients with Severe Acquired Brain Injury
Severe Acquired Brain Injury (sABI), with a more or less prolonged state of coma, generally causes disruption of the physiological modes of swallowing and feeding and the physiological abilities of communication and phonation.
- Trial name
- NCT05729165
- Testing
- Novafon® Pro, Conventional Therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Head and Neck Cancer, Ototoxicity
Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal…
- Conditions
- Head and Neck Cancer, Ototoxicity, Radiation Toxicity
- Trial name
- NCT01216800
- Testing
- adjuvant therapy, assessment of therapy complications, quality-of-life assessment
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Spinal Accessory Nerve Injury, Cervical Lymphadenopathy
Do AxoGuard Implants Decrease Shoulder Disability After Neck Dissections
The purpose of this study is to determine whether Axoguard nerve protectors have a role in preventing shoulder disability and pain following spinal accessory nerve sparing neck dissections.
- Trial name
- NCT03941327
- Testing
- AxoGuard Nerve Cuff
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Mississippi Medical Center
Acquired Brain Injury
Effects of Combined Spinal Direct Current Stimulation on Upper Limb Recovery in Acquired Brain Injury
This study will compare different polarities of transcutaneous spinal direct current stimulation combined with robotic-assisted arm training (RAT) in adults with acquired brain injury (ABI).
- Trial name
- NCT03100370
- Testing
- tsDCS-Anodal Stimulation, tsDCS-Cathodal Stimulation, Robotic-assisted training of arm and hand functions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury, Post-traumatic Epilepsy
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12…
- Trial name
- NCT05823766
- Testing
- In-Person Outcome Assessment, 3T Magnetic Resonance Imaging (MRI), Clinical Visit
- Where
- 9 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Brain Concussion, Post-Concussion Syndrome
Exercise in Postconcussion Symptoms and Posttraumatic Headache
The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.
- Conditions
- Brain Concussion, Post-Concussion Syndrome, Post-Traumatic Headache, Craniocerebral Trauma
- Trial name
- NCT06015451
- Testing
- Sub-symptom threshold exercise
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Brain Injuries
Manual-Based Vocational Rehabilitation Program for Patients With Acquired Brain Injury
An acquired brain injury (ABI) is a complex injury often followed by a broad range of cognitive, physical, emotional, and behavioral disabilities.
- Trial name
- NCT03086031
- Testing
- Program -based vocational rehabilitation intervention, Conventional vocational rehabilitation (controls)
- Volunteers
- 84 people
- Sponsor
- Brain Injury Center BOMI, Roskilde, Denmark