Clinical trials: Head Trauma Injury
Head Injury, Intracranial Pathology
Effect of Intrathoracic Pressure Regulation on Decreased Cerebral Perfusion
The purpose of the study is to evaluate the physiological response to application of the Intrathoracic Pressure Regulator (ITPR) in patients with compromised cerebral circulation.
- Conditions
- Head Injury, Intracranial Pathology, Compromised Cerebral Perfusion
- Trial name
- NCT01824576
- Testing
- ITPR
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Advanced Circulatory Systems
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Ischemic Reperfusion Injury, Other Reconstructive Surgery
RIPC During Free Flap With Preoperative Radiotherapy
Remote ischemic preconditioning (RIPC) has shown organ-protective effects in many clinical settings including patients with ischemic heart disease.
- Conditions
- Ischemic Reperfusion Injury, Other Reconstructive Surgery, Radiotherapy
- Trial name
- NCT03535623
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Head Injury, Sport Injury
Evidence-based Intervention for Improved Head Impact Safety in Youth Football - Aim 1 and Aim 3
Two middle school (ages 11-14) football teams will be in Aim 1 of this study. All interested athletes on these teams will be invited to voluntarily participate in biomechanical data collection; of those enrolled, 15-20 per team…
- Trial name
- NCT04908930
- Testing
- On-field activity group - Aim 3
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
TBI (Traumatic Brain Injury)
A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection
The purposes of this study are: 1. To determine the sensitivity and specificity of the Near-Infrared Spectroscopy (NIRS) measurements for identifying intracranial hematomas due to trauma. 2.
- Trial name
- NCT00576147
- Testing
- Infrascanner
- Where
- 4 sites in United States
- Volunteers
- 431 people
- Sponsor
- InfraScan, Inc.
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health
Hemorrhagic Shock, Traumatic Brain Injury
Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
The LITES Network is an operational trauma center consortium which has the expertise, track record and confirmed capabilities to conduct prospective, multicenter, injury care and outcomes research of relevance to the Department…
- Trial name
- SWAT (NCT03402035)
- Where
- United States
- Volunteers
- 1,051 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).
- Trial name
- NCT00893789
- Testing
- Armodafinil
- Where
- 73 sites in United States, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- Cephalon, Inc.
Traumatic Brain Injury
A Culturally Sensitive Intervention for TBI Caregivers in Latin America
Traumatic brain injury (TBI) patients in Latin America experience high levels of disability and extremely poor functional outcomes, and their informal caregivers play a key role in their rehabilitation and care.
- Trial name
- NCT02207803
- Testing
- Transition Assistance Program
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 250 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury
Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness
The purpose of this study is to examine the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with Amantadine relative to rTMS Alone and Amantadine Alone for persons in chronic states of…
- Trial name
- NCT02025439
- Testing
- rTMS, Amantadine
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Edward Hines Jr. VA Hospital
Traumatic Brain Injury
CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI
The research aims of the CENTER-TBI study are to: 1. better characterize Traumatic Brain Injury (TBI) as a disease and describe it in a European context, and 2. identify the most effective clinical interventions for managing TBI.
- Trial name
- CENTER-TBI (NCT02210221)
- Where
- 65 sites in Austria, Belgium and 17 more
- Volunteers
- 4,559 people
- Sponsor
- University Hospital, Antwerp
Chronic Traumatic Brain Injury
Association of Amino Acid Prevalence and Chronic Brain Injury
Years after a suffering a brain injury, individuals remain in a physically and cognitively impaired state. The investigators believe that the concentrations of amino acids in the blood are chronically altered and yield negative…
- Trial name
- NCT02113124
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Brent Masel
Mild Traumatic Brain Injury
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury
Aim 1: To use magnetoencephalography (MEG) and magnetic resonance imaging (MRI) in Veterans and civilians with mild traumatic brain injury (mTBI) and sensory postconcussive symptoms (PCS) to demonstrate the mechanism of…
- Trial name
- NAVIGATE-TBI (NCT03799458)
- Testing
- Active High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Upper Extremity Spasticity, Stroke
Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity
FES is a form of treatment with a device to aid movement in people who have had damage to their brain or spinal cord. Small electrical impulses are used to excite/stimulate the nerves that supply paralyzed muscles.
- Conditions
- Upper Extremity Spasticity, Stroke, Acquired Brain Injury
- Trial name
- Botox + FES (NCT00462449)
- Testing
- Functional Electrical Stimulation (FES) through the Ness H200
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Brain Injury
Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) is a significant public health problem, with 1.5-2.0 million Americans injured each year. Cognitive deficits, particularly in the domains of memory and attention are frequently the source of lingering…
- Trial name
- NCT00453921
- Testing
- Methylphenidate, Memory and Attention Training
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Posttraumatic Stress Disorder, Depression
Trauma Survivors Outcomes and Support Study IV
After traumatic injuries some people have difficulty returning to the routine of their everyday activities and may experience physical and emotional pain.
- Conditions
- Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury
- Trial name
- TSOS IV (NCT01625416)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Vestibular Deficits
Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation
The goal of this clinical research study at RIC is to determine the value and benefit of the SK multimodal balance training system through independent clinical evaluations.
- Trial name
- NCT01672658
- Testing
- Sensory Kinetics Balance System, Traditional Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Shirley Ryan AbilityLab
Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury
Background: Obstructive sleep apnea (OSA) is a sleep disorder common among Veterans with moderate-to-severe traumatic brain injury (TBI).
- Trial name
- FISATABI (NCT04221009)
- Testing
- MI and CBT 4-session manualized intervention
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Each year in the United States alone, a third of a million persons are hospitalized for traumatic brain injury (TBI), of whom approximately 1/4 die. Most are less than 30 years of age.
- Trial name
- RESCUE-TBI (NCT00973674)
- Testing
- Premarin IV
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Post-traumatic Stress Disorder
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
The scientific objective of this program is to meet the rehabilitation needs of combat wounded Veterans with mild to moderate Traumatic Brain Injury (TBI) via telerehabilitation and determine the effect of this modality of care…
- Trial name
- NCT00676182
- Testing
- Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development