Clinical trials: Head Trauma Injury
Injuries, Acute Brain
Protective Ventilatory Strategy in Severe Acute Brain Injury
Acute respiratory distress syndrome (ARDS) occurs in almost 20% of patients with severe acute brain injury and is associated with increased morbidity and mortality.
- Trial name
- PROLABI (NCT01690819)
- Testing
- Conventional Ventilatory Strategy, Protective Ventilatory Strategy
- Where
- Italy
- Volunteers
- 524 people
- Sponsor
- University of Turin, Italy
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Tracheostomy, Brain Injuries
Pilot Study Evaluating the Success (= Safe Decannulation) of a Standardized Tracheotomy Weaning Procedure in Brain-injury's Patients
Tracheotomy weaning and decannulation are one of the important problems in the neurosurgical care unit. Aside from medical, psychological, sociological, economical and ethics problems, tracheotomy increases the duration of the…
- Trial name
- DECATRAC (NCT03512054)
- Testing
- Standardized 5-step weaning procedure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Traumatic Brain Injury, Subarachnoid Hemorrhage
Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study
The NeurO2 study is a multicenter observational study looking at NIRS monitoring in neurocrocritically ill patients during the acute phase of care following an acute brain injury.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy
- Trial name
- NeurO2 (NCT04935866)
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 2 sites in Canada
- Volunteers
- 286 people
- Sponsor
- CHU de Quebec-Universite Laval
Head Trauma
Medicolegal Aspects of Head Trauma
Trauma is a critical global health problem. It represents the fifth leading cause of significant disability and is one of the most common causes of mortality in youth and adulthood, as one in 10 deaths worldwide occurred due to…
- Trial name
- NCT05386966
- Testing
- questionnaire
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Central Auditory Processing Disorder, Traumatic Brain Injury
Central Auditory Processing Disorders Associated With Blast Exposure
The incidence of central auditory dysfunction in war fighters who are exposed to high-explosive blasts while serving in combat have not been clearly determined.
- Conditions
- Central Auditory Processing Disorder, Traumatic Brain Injury, Hearing Loss
- Trial name
- NCT00554801
- Testing
- Audiological testing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Alzheimer's Disease, Traumatic Brain Injury
Clinical Evaluation of Flortaucipir F 18
This study is designed to expand the database of flortaucipir F 18 safety and tau binding as measured by PET imaging and to provide standardized conditions for flortaucipir PET use, data collection and analysis to facilitate…
- Conditions
- Alzheimer's Disease, Traumatic Brain Injury, Depression
- Trial name
- NCT02278367
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 5 sites in United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Concussion, Brain, Traumatic Injury
Sport Concussion Performance-Based Prevention Program
Sport-related concussions and traumatic lower body injuries (e.g., anterior cruciate ligament (ACL) tears) occur frequently in high-speed and contact/collision sports contributing to significant time loss from…
- Trial name
- NCT04992130
- Testing
- Pre-season supplementary neurologic training program
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Minor Head Injury, Traumatic Brain Injury
Diagnostic Algorithm in Patients With Minor Head Injury
The objective of this prospective study is to evaluate the reliability of plain x-rays vs.cranial computed tomography as a screening method for skull fractures and its prognostic value for intracranial bleeding (ICB).
- Trial name
- NCT00452036
- Where
- Austria
- Volunteers
- 12,500 people
- Sponsor
- Medical University of Vienna
Brain Death
Organ Donation and Hydrocortisone Treatment
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure.
- Trial name
- HYDRO (NCT00675272)
- Testing
- hydrocortisone, sodium chloride
- Where
- 2 sites in Finland
- Volunteers
- 38 people
- Sponsor
- Kuopio University Hospital
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Head Injury, Subarachnoid Hemorrhage
Influence of Drainage on EVD ICP-signal
This observational study investigates ICP signals obtained through an external ventricular drain in the brain connected with an external transducer.
- Trial name
- NCT03164434
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Traumatic Brain Injury, Concussion
Advancement of Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
The goal is to assess the potential benefit of stochastic galvanic vestibular stimulation (sGVS) in improving patient performance with respect to balance, gait, and/or overall vestibular function for individuals with known…
- Trial name
- NCT07466589
- Testing
- Stochastic Galvanic Vestibular Stimulation (sGVS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vivonics, Inc.
Sarcopenic Obesity, Spinal Cord Injuries
Sarcopenic Obesity in Neurodisabilities
To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities
- Conditions
- Sarcopenic Obesity, Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- SarcObeNDS (NCT03863379)
- Testing
- whole body DXA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Thoracic Surgery, Cardiopulmonary Bypass
Cerebral Autoregulation Monitoring During Cardiac Surgery
Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life.
- Trial name
- NCT00981474
- Testing
- blood pressure maintenance based on cerebral blood flow autoregulation measurement, Control group
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Northwestern University
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Cerebral Concussion
Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants
Healthy (non-injured) and concussed college-aged participants will complete two testing sessions that include (1) clinical symptom, balance, and cognitive evaluations and (2) a progressive exercise session to establish symptom…
- Trial name
- ACTIVE (NCT02872480)
- Testing
- ACTIVE Training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Anosmia, COVID-19
Characteristics of the Anosmic Olfactory Mucosa
The present study aims to describe the structural tissue and cell characteristics of the olfactory mucosa in patients with persistent anosmia (≥2 years) due to COVID-19 or head-trauma, in comparison to healthy individuals with…
- Conditions
- Anosmia, COVID-19, Head Injury
- Trial name
- NCT05562050
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Nicolai Nielsen
Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome
The investigators have designed an innovative proof-of-concept trial designed to provide data as to whether the treatment/rehabilitation efficacy and functional outcome of patients with organic brain syndrome are improved with…
- Conditions
- Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders, Mental Disorder, Organic, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT02957123
- Testing
- Intranasal auto-M2-BFs
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Russian Academy of Medical Sciences