Clinical trials: Head and Neck Cancer Patients
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma
SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes
The purpose of this study is to test the good and bad effects of an experimental drug called SF1126. This drug is being tested in patients whose cancer has not been controlled by available standard therapies and who have certain…
- Trial name
- NCT02644122
- Testing
- SF1126
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ezra Cohen
Circulating Tumor Cell, HNSCC
Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer
Cancer has been a significant cause of human death in the recent two decades, although detection, diagnosis, and cancer treatments improved and evolved rapidly.
- Trial name
- NCT06755762
- Testing
- Organoid 3D culture
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Esophageal Cancer, Gastric Cancer
A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors
This phase II study is a clinical study to explore the efficacy and safety of SI-B003 Monotherapy, BL-B01D1+SI-B003 Combination Therapy and BL-B01D1+PD-1 Monoclonal Antibody in patients with locally advanced or metastatic…
- Conditions
- Esophageal Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT06008054
- Testing
- SI-B003, BL-B01D1, PD-1 Monoclonal Antibody
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Cancer of Head and Neck, Neoplasms, Head and Neck
Phase I Chemoprevention Trial With Green Tea Polyphenon E & Erlotinib in Patients With Premalignant Lesions of the Head & Neck
The purpose of this study is to test the preventive effects of a combination of drugs: polyphenon E (PPE) derived from green tea extracts, and erlotinib.
- Trial name
- NCT01116336
- Testing
- Erlotinib, Green Tea Polyphenon E
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Barrett's Esophagus, Esophageal Neoplasms
Endoscopic Resection or Ablation for Patients With Dysplasia or Cancer Requiring Treatment of Barrett's Esophagus
This clinical trial will evaluate a patient population with Barrett's esophagus(BE) containing high grade dysplasia or intramucosal cancer and compare the effects of endoscopically-guided radiofrequency ablation system(RFA) and…
- Trial name
- ERADICATE (NCT01572987)
- Testing
- Radiofrequency Ablation(RFA) by HALO device., Endoscopic mucosal resection(EMR) by mucosectomy kit.
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Midwest Biomedical Research
Thyroid Tumor
Effect of Early Postoperative Drinking Water on Postoperative Recovery Quality of Patients With Thyroid Surgery
This study is a single-center, prospective and randomized controlled study to investigate the effects of early recovery of oral intake (E) and late recovery of oral intake (L) on postoperative recovery quality and satisfaction of…
- Trial name
- NCT05532384
- Testing
- Early resumption of oral intake, Late resumption of oral intake
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, High Grade Serous Ovarian Cancer
A Phase I Trial of LY3143921 Hydrate in Solid Tumours
This clinical study looked at a drug called LY3143921 hydrate (a Cdc7 inhibitor) in adult patients with advanced solid tumours. The main aims were to find out the maximum dose of LY3143921 hydrate that could be given safely to…
- Conditions
- Colorectal Cancer, High Grade Serous Ovarian Cancer, Non Small-cell Lung Cancer (Squamous Cell Variant), Urothelial Cancer
- Trial name
- NCT03096054
- Testing
- LY3143921 hydrate
- Where
- 4 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- Cancer Research UK
Esophageal Cancer
Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC
This study was conducted in elderly (≥70 years old) patients with locally advanced esophageal squamous cell carcinoma (ESCC). Aim to evaluate the efficacy and safety of Iparomlimab consolidation therapy following concurrent…
- Trial name
- NCT07038629
- Testing
- S1, Iparomlimab, Radiation
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Smoking, Head and Neck Neoplasms
Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients
The purpose of this study is to determine whether a brief smoking ENT-resident-based intervention increased smoking cessation in patients with Head and Neck cancer attending a Lebanese university hospital, as compared with usual…
- Trial name
- NCT03786172
- Testing
- Smoking cessation Intervention, Usual care
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people
- Sponsor
- Saint-Joseph University
Head and Neck Neoplasms
Study of Intralesional Injection of M4N in Patients With Refractory Malignant Tumors of the Head and Neck
The purpose of this study will be to determine the safety and tolerability of intratumoral M4N. Patients suffering from cancer of the head and neck that is recurrent after primary treatment with surgery, radiation therapy, and/or…
- Trial name
- NCT00057512
- Testing
- M4N
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Erimos Pharmaceuticals
Head and Neck Cancer
Preemptive Treatment With XONRID to Reduce Radiation Induced Dermatitis in Head and Neck Cancer Patients
There is a strong need to study products with a preemptive role in radiation dermatitis development, with a trial design taking in account patient subjective evaluation and compliance.
- Trial name
- NCT02261181
- Testing
- XONRID
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Head and Neck Cancer, Precancerous/Nonmalignant Condition
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, precancerous cells and cancer cells are killed.
- Trial name
- NCT00453336
- Testing
- Porfimer Sodium, Photodynamic Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Oropharyngeal Cancer, HPV-Related Squamous Cell Carcinoma
PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing
Enrollment is only available to patients enrolled on the Optima II study (NCT03107182). The purpose of this trial is to compare rates of opioid use at completion of radiation for patients with Common Terminology Criteria for…
- Trial name
- NCT03423264
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- University of Chicago
Head and Neck Cancer
Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00004164
- Testing
- filgrastim, cisplatin, docetaxel
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Unspecified Adult Solid Tumor, Protocol Specific
Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI
A modular, first time in human, open label, multiple dose, accelerated escalation with cohort expansion study of the safety and pharmacokinetics of intravenous infusion of CP-506, a tumor agnostic Hypoxia Activated Prodrug in…
- Trial name
- NCT04954599
- Testing
- CP-506, Carboplatin, Immune checkpoint inhibitor
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 126 people
- Sponsor
- Maastricht University Medical Center
Esophageal Neoplasms, Neoplasms
Autologous Tumor Tissue Antigen-sensitized DC-CIK Cells Combined With Chemotherapy for Esophageal Cancer
This study evaluates the safety and efficacy of D-CIK immune cells combined with chemotherapy after resection of esophageal cancer
- Conditions
- Esophageal Neoplasms, Neoplasms, Digestive System Neoplasms, Esophageal Cancer
- Trial name
- NCT02644863
- Testing
- Paclitaxel, DC-CIK, Cisplatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Oesophageal Cancer
Patient Priorities in the Management of Early Oesophageal Cancer: A Discrete Choice Study
Understanding patient priorities is important to providing thorough, individualised care in oesophageal cancer. We aim to use questionnaires to explore what is important to patients when considering radical surgery for…
- Trial name
- NCT07828314
- Testing
- Semi-structured interview, Discrete Choice Experiment
- Where
- United Kingdom
- Volunteers
- 118 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Thyroid Cancer
Efficacy of Subfascial Approach in Thyroidectomy to Quality of Life in Thyroid Disease Patients
Subfascial approach method in thyroidectomy maybe result in better quality of life than conventional approach method in thyroid disease patients
- Trial name
- NCT01616316
- Testing
- subfascial flap, subplatysmal flap
- Where
- South Korea
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Esophageal Cancer
Sunitinib in Treating Patients With Relapsed or Refractory Esophageal or Gastroesophageal Junction Cancer
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00702884
- Testing
- sunitinib malate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Tony Bekaii-Saab
Oral Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Carrimycin in Patients With Locally Advanced, Recurrent, or Metastatic HNSCC (Non NPC): A Phase I Trial
The trial is a study conducted to evaluate the safety, tolerability and PK characteristics of Carrimycin tablet and measure its anti-tumor efficacy initially in the treatment of patients with locally advanced, recurrent, or…
- Trial name
- NCT04413214
- Testing
- Carrimycin
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine