Clinical trials: Head and Neck Cancer Patients
Radiation- Induced Mucositis, Adverse Effect of Radiation Therapy
Prevention of Mucositis in Patients With Head and Neck Cancer Treated With Radiotherapy
Prevention of radiation-induced mucositis in patients with head and neck cancer treated with radiotherapy : A Double-blind Randomized Controlled Trial
- Conditions
- Radiation- Induced Mucositis, Adverse Effect of Radiation Therapy, Head and Neck Cancer
- Trial name
- NCT03359187
- Testing
- Normal saline with salt/Soda, Clinacanthus nutans, Boesenbergia rotunda
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chulabhorn Hospital
Locally Advanced or Metastatic Solid Tumors, NSCLC
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
This is a first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of enzelkitug when administered as a single agent and in combination with atezolizumab or pembrolizumab in adult…
- Conditions
- Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma
- Trial name
- NCT05581004
- Testing
- Enzelkitug, Atezolizumab, Pembrolizumab
- Where
- 36 sites in United States, Australia and 8 more
- Volunteers
- 165 people
- Sponsor
- Genentech, Inc.
Head and Neck Cancer, Caries, Dental
Post-radiation Dental Disease Amongst Head and Neck Cancer Patients
Background Post-radiotherapy head and neck cancer (HANC) patients are at increased risk of dental caries and periodontal disease due to radiation-related damage to the teeth and salivary glands.
- Conditions
- Head and Neck Cancer, Caries, Dental, Periodontal Diseases, Radiotherapy Side Effect
- Trial name
- NCT03703648
- Testing
- Radiotherapy (curative) for head and neck cancer
- Where
- United Kingdom
- Volunteers
- 215 people
- Sponsor
- Belfast Health and Social Care Trust
Head and Neck Cancer
Benefit of Paramedical Care in Accompanying Caregivers of Patients That Had Surgery for an Head and Neck Invasive Cancer
Head and Neck invasive cancer usually requires surgery that is associated with modifications of the body structure of patient regarding breathing, eating and communication.
- Trial name
- AIDORL (NCT05542706)
- Testing
- Accompanying caregivers by paramedical team
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Henri Becquerel
Head and Neck Carcinoma, Hypopharyngeal Carcinoma
Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers
This phase IV trial compares how well methadone plus standard fentanyl given during surgery (intraoperative) works compared to intraoperative standard fentanyl alone in managing pain after surgery (postoperative) among patients…
- Conditions
- Head and Neck Carcinoma, Hypopharyngeal Carcinoma, Laryngeal Carcinoma, Oral Cavity Carcinoma
- Trial name
- NCT07857655
- Testing
- Electronic Health Record Review, Fentanyl, Laryngoscopy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer, Metastatic Gastric Cancer
Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer
The primary objective of this pharmacokinetics study is to compare the maximum concentration level of paclitaxel in patients with low/sarcopenic skeletal muscle area (SMA), at the end of a 2-3 hour paclitaxel infusion, to the…
- Conditions
- Breast Cancer, Metastatic Gastric Cancer, Esophageal Cancer
- Trial name
- NCT05183126
- Testing
- Paclitaxel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan Rogel Cancer Center
Head and Neck Cancer
PET/MR in Radiotherapy for Head and Neck Cancer Pilot
This is a pilot non-intervention study that aims to introduce PET/MRI, a state of the art new imaging technique, into the radiotherapy treatment pathway of patients with head and neck cancer.
- Trial name
- NCT02952625
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Head and Neck Cancer
Induction Chemotherapy With Nimotuzumab in Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
The aim of the study is to evaluate the role of nimotuzumab in the neo-adjuvant setting in patients with locally advanced HNSCC.
- Trial name
- NCT00910117
- Testing
- nimotuzumab, PF regimen (cisplatin and 5-FU)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Head and Neck Cancer
Nutritional Status Assessment in Head and Neck Cancer Patients Receiving Radiotherapy or Chemo-radiotherapy
Radiotherapy and chemotherapy are standard treatment of head and neck cancer alone or associated to surgical treatment. Early (during treatment or the following weeks) and late side effects contribute to malnutrition in this…
- Trial name
- NUTRINECK (NCT02900963)
- Testing
- weekly assessment of patient's weight
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Centre Henri Becquerel
Metastatic Pancreatic Cancer, Colorectal Cancer
A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer, and Other Advanced Solid Tumors
The purpose of this study is to confirm the safety and tolerability of TAK-931 in a cohort of Western participants with metastatic solid tumors and to evaluate the anti-tumor activity of TAK-931 in participants with metastatic…
- Conditions
- Metastatic Pancreatic Cancer, Colorectal Cancer, Esophageal Neoplasms, Carcinoma, Non-small-cell Lung
- Trial name
- NCT03261947
- Testing
- TAK-931
- Where
- 10 sites in United States, Japan
- Volunteers
- 101 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Thyroid Cancer
Comparison of Iodine-124 (I-124) and Iodine-131 (I-131) Radiopharmacokinetics in Patients Prepared With Recombinant Human TSH Injection (rhTSH)
This research study is to compare the radiopharmacokinetics of I-124 to the radiopharmacokinetics of I-131 in patients who have well-differentiated thyroid cancer after recombinant human thyroid-stimulating hormone (rhTSH)…
- Trial name
- NCT00926978
- Testing
- Radioactive Iodine 124
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medstar Health Research Institute
Head and Neck Cancer
Lymphoscintigraphy to Detect Early Metastases in Patients With Cancer of the Mouth or Throat
RATIONALE: New imaging procedures such as lymphoscintigraphy may improve the ability to detect the spread of mouth and throat cancer to lymph nodes in the neck.
- Trial name
- NCT00012168
- Testing
- isosulfan blue, polymerase chain reaction, immunohistochemistry staining method
- Where
- United States
- Sponsor
- NYU Langone Health
Esophageal Cancer
Paclitaxel Liposome and Cisplatin as First-line Chemotherapy in Patients With Metastatic Esophageal Cancer
There are no standard chemotherapy regimens for metastatic esophageal cancer. Cisplatin plus 5-fluorouracil is widely used as first-line treatment with a response rate ranged from 30% to 40%.
- Trial name
- NCT01998347
- Testing
- Paclitaxel liposome, Cisplatin, 5-fluorouracil
- Where
- China
- Sponsor
- Shantou University Medical College
Sedation, ICU
RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery
Remimazolam besylate, as a new benzodiazepine drug, showing rapid clearance and moderate distribution of pharmacokinetic changes.
- Conditions
- Sedation, ICU, Remimazolam Besylate
- Trial name
- NCT05606315
- Testing
- Remimazolam Besylate, Propofol, Midazolam
- Where
- 2 sites in China
- Volunteers
- 117 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Head and Neck Cancer
A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy
Head and neck cancer is the malignant tumor with the highest morbidity and mortality, of which 60% present with locally advanced disease at initial diagnosis, and the 5-year survival rate of standard treatment is less than 30%.
- Trial name
- NCT06208826
- Testing
- Toripalimab, Radiation Therapy, Cisplatin
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer, Esophageal Cancer
Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy volunteers undergoing colonoscopy or endoscopy may help doctors identify and learn more about…
- Conditions
- Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT00899626
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia
Innovative Patient-partner-guided Virtual Group Speech Pathology Intervention Model in Head and Neck Cancer
This project aims to study an innovative intervention, the eG2 Intervention, developed by speech-language pathologists at the Centre hospitalier de l'Université de Montréal to improve therapeutic adherence and prevent dysphagia…
- Trial name
- NCT05621889
- Testing
- virtual group speech therapy intervention guided by a patient partner
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Oropharynx Cancer, Head and Neck Cancer
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia
Radiation-induced xerostomia (dry mouth) is one of the most common and severe toxicities experienced by patients undergoing radiation treatment for head and neck cancer.
- Conditions
- Oropharynx Cancer, Head and Neck Cancer, Xerostomia
- Trial name
- NCT06276946
- Testing
- standard radiotherapy, experimental radiotherapy
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer (H&N)
Swallowing Rehabilitation Program for Head and Neck Tumor Patients
This study aims to evaluate the effect of a structured swallowing rehabilitation program on swallowing function, trismus severity, and pain among patients with head and neck tumors, using a randomized controlled trial design.
- Trial name
- SREP-HNC (NCT07795294)
- Testing
- Swallowing Rehabilitation Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Delta University for Science and Technology
Thyroid Cancer, Lymph Node Metastases
Predictive Factors of Lymph Node Metastasis in Patients With Papillary Microcarcinoma of the Thyroid
Papillary thyroid microcarcinoma (PTMC), defined as a tumor with larger diameter ≤ 1 cm, is considered a tumor with an indolent course and an excellent prognosis.
- Trial name
- NCT04274829
- Testing
- Thyroidecomt and lymphectomy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
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