Clinical trials: Head and Neck Tumor
Liver Cancer, Pancreas Cancer
PRIORITY-CONNECT 2 Pilot Trial
The provision of preoperative interventions (prehabilitation: including exercise, nutrition, and psychological treatment) have been reported to reduce postoperative complications by as much as 50% and reduce hospital stay by up…
- Conditions
- Liver Cancer, Pancreas Cancer, Oesophageal Cancer, Gastric Cancer
- Trial name
- NCT06212700
- Testing
- Preoperative Exercise, Postoperative Exercise, Preoperative Nutrition
- Where
- 2 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
HEAD AND NECK CANCER, CARCINOMA OROPHARYNX
Evaluation of 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Cancer.
This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error…
- Conditions
- HEAD AND NECK CANCER, CARCINOMA OROPHARYNX, CARCINOMA PYRIFORM SINUS, CARCINOMA LARYNX
- Trial name
- NCT01124409
- Testing
- EPID Verification, CBCT verification
- Where
- India
- Volunteers
- 41 people
- Sponsor
- All India Institute of Medical Sciences
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
To Compare the Effect of Different Nutritional Pathways on Improving Nutritional Status of Esophageal Cancer Patients Undergoing Chemoradiotherapy
This study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (NG), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Enteral Nutrition
- Trial name
- NCT04199832
- Testing
- Dietary guidance
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Malignant Neoplasm in the Head and Neck, Metastatic Malignant Neoplasm in the Head and Neck
Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes
This phase I trial tests whether embolization done prior to surgery (preoperative) will improve surgical outcomes in head and neck tumors with large amounts of blood vessels (hypervascular).
- Trial name
- NCT05490381
- Testing
- Iodixanol, Angiogram, Arterial Embolization
- Where
- United States
- Sponsor
- University of Washington
Cancer of the Head and Neck
PET With [18F]HX4 in Head and Neck Cancer
The aim of this study is to (i) Determine if tumor hypoxia can be accurately visualised with [18F] HX4 PET imaging in head and neck tumors (ii) correlate the [18F] HX4 PET images with blood and tissue markers and (iii)…
- Trial name
- NCT01347281
- Testing
- Injection of [18F]HX4
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht Radiation Oncology
Cancer of Head and Neck, Narcotic Use
Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery
Patients undergoing head and neck cancer surgery often have a lot of pain after surgery, which can lead to a need for a lot of narcotic pain medication.
- Trial name
- NCT03682367
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Davis
Thyroid Nodular Disease
Microvascular Profiling of Nodules in the Thyroid Gland
The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more…
- Trial name
- NCT07041307
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head and Neck Cancer, Prostate Cancer
Application of High Resolution Diffusion-weighted MR Imaging Pulse Sequence in Head and Neck, and Prostate Cancers
Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the body using magnetic field and radio frequency pulses that can not be felt.
- Trial name
- NCT01535898
- Testing
- MRI scanner with sequence
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nasopharyngeal Neoplasms
Combination of Docetaxel, Cisplatin, and Capecitabine (DCX) in the Treatment of Nasopharyngeal Carcinoma
The standard treatment strategy for locally advanced (stage IVA) and metastatic (stage IVB) nasopharyngeal carcinoma has not been defined yet.
- Trial name
- NCT02360501
- Testing
- Docetaxel, Cisplatin, Capecitabine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer, Free Tissue Transfer
Local Infusion of Ropivacaine for Post-Op Pain Control After Osseocutaneous Free Flaps
Head and neck oncologic surgery often requires the use of free tissue transfer, or microvascular reconstruction, to reconstruct defects created by tumor resections.
- Trial name
- NCT03349034
- Testing
- Ropivicaine, Local Saline Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7
Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma
This phase I trial studies the side effects and best dose of pembrolizumab when given together with cisplatin and intensity-modulated radiation therapy, in treating patients with stage III-IV squamous cell carcinoma of the head…
- Conditions
- Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Trial name
- NCT02775812
- Testing
- Cisplatin, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis
- Where
- 69 sites in United States
- Volunteers
- 37 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Neoplasms
Study of Anlotinib Hydrochloride Capsules in the Treatment of Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma
The study aims to observe and investigate the efficacy and safety of Anlotinib capsules in patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid carcinoma in the real world, and to summarize…
- Trial name
- NCT05994365
- Testing
- Anlotinib Hydrochloride Capsule
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Squamous Cell Carcinoma of Head and Neck
sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC
This is a Phase I dose-escalation study of sEphB4-HSA in combination with chemotherapy, cetuximab and radiotherapy (RT). The purpose is to estimate the maximum tolerated dose (MTD) that can be administered concurrently with…
- Trial name
- NCT04091867
- Testing
- sEphB4-HSA with chemotherapy, Cetuximab, Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Head and Neck Squamous Cell Carcinoma, Hypofractionation
HYpofractionated, Dose-redistributed RAdiotherapy With Protons and Photons in HNSCC
Radiotherapy for advanced-stage head and neck squamous cell carcinoma (HNSCC) results in an unfavorable 5-year overall survival of 40%, and there is a strong biological rationale for improving outcome by combinatorial treatment…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Hypofractionation, Radiotherapy, Proton Therapy
- Trial name
- HYDRA (NCT05364411)
- Testing
- HYpofractionated, Dose-redistributed RAdiotherapy (HYDRA), conventional fractionated radiotherapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Joris B.W. Elbers
Nasopharyngeal Carcinoma
Whole-target Consolidation Therapy Under Systemic Therapy for Oligometastatic Nasopharyngeal Carcinoma
In this exploratory clinical trial, patients with newly diagnosed distant metastatic nasopharyngeal carcinoma were treated with gemcitabine+ cisplatin+PD-1 inhibitor regimen followed by whole-target radiotherapy (IMRT for local…
- Trial name
- NCT05431764
- Testing
- Camrelizumab, gemcitabin, cisplatin, Stereotactic Body Radiotherapy, Intensity modulated-radiotherapy
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Sun Yat-sen University
Malnutrition, Esophageal Cancer
INEC Study: Immuno-modulating Enteral Nutrition in Cancer
The aim of this study is to investigate if enteral immunonutrition of head and neck or esophageal cancer patients, using an arginine, omega 3 fatty acid, nucleotides-enhanced diet [Impact (R), Novartis] versus a standard enteral…
- Conditions
- Malnutrition, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00333099
- Testing
- Impact (R) Enteral Nutrition, impact
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nasopharyngeal Carcinoma
Pretreatment With HCQ Before Radiotherapy and Chemotherapy in Advanced NPC Patients
Dormant cancer cells that survive anti-cancer therapy can lead to cancer recurrence and disseminated metastases that prove fatal in most cases.
- Trial name
- NCT06389201
- Testing
- HCQ
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
Thyroid Cancer
Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study
Background: The Ukrainian Research Center for Radiation Medicine and the U.S. National Institutes of Health have been studying cancer risks and outcomes in individuals who participated in the decontamination clean-up process…
- Trial name
- NCT01265381
- Where
- Ukraine
- Volunteers
- 673 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Pancreatic Cancer
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT02584244
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Lumicell, Inc.
Head and Neck Squamous Cell Carcinoma
Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC
The purpose of the study is to determine if cemiplimab in combination with cetuximab given before their surgery are beneficial and safe in participants with head and neck squamous cell carcinoma (HNSCC).
- Trial name
- NCT06855212
- Testing
- Cemiplimab, Cetuximab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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