Clinical trials: Head and Neck Tumours
Salivary Gland Tumors, Head and Neck Cancer
Postoperative Concurrent Chemoradiotherapy in Treating Patients With High-Risk Salivary Gland Carcinomas
This is a non-randomized, phase II, open label study of postoperative current chemoradiotherapy for high-risk malignant salivary gland tumors of head and neck.The primary purpose of this study is to evaluate the efficacy and…
- Trial name
- NCT02776163
- Testing
- Nedaplatin, Docetaxel, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Head and Neck Squamous Cell Carcinoma
Ribociclib and Spartalizumab in R/M HNSCC
This study examines the safety and efficacy of ribociclib (CDK 4/6 inhibitors) and spartalizumab (anti-PD1) in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC).
- Trial name
- RISE-HN (NCT04213404)
- Testing
- Ribociclib, Spartalizumab
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Head and Neck Squamous Cell Carcinoma
A Study of Apatinib Plus Tegafur Gimeracil Oteracil in Recurrent/Metastatic Head and Neck Cancers
This is a non-randomized, phase II, open label study of apatinib mesylate tablets plus tegafur gimeracil oteracil potassium capsules in recurrent/metastatic squamous cell carcinoma of head and neck.
- Trial name
- NCT03096184
- Testing
- Apatinib Mesylate Tablets, Tegafur Gimeracil Oteracil Potassium Capsules
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Squamous Cell Carcinoma of Head and Neck
5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC
This study is being done because both 5-azacytidine and nivolumab can influence the immune system's response to HPV-associated head and neck cancer, and we wish to evaluate whether taking 5-azacytidine will make HPV-associated…
- Trial name
- NCT05317000
- Testing
- Combination 5-azacytidine and nivolumab, Nivolumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Barbara Burtness
Breast Cancer, Lung Cancer
Pillars4Life Trial
This study aims to explore whether cancer patients can benefit from completing the Pillars4Life online coping program. This randomized control trial will have half its subject completing the program and the other half receiving…
- Conditions
- Breast Cancer, Lung Cancer, Esophageal Cancer, Colon Cancer
- Trial name
- Pillars4Life (NCT02465892)
- Testing
- Pillars4Life
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- Duke University
Thyroid Cancer, Relapse
Comparison DW-MRI vs FDG PET/CT in the Detection of Early Recurrence of Cervical Well-differentiated Thyroid Carcinoma
The purpose of the study is to evaluate the concordance between the 18F-PET/CT under thyrotropin stimulation and the diffusion-weighted Magnetic Resonance Imaging, in the detection of residual mass in 40 patients with partial…
- Trial name
- THYRIRMTEP (NCT02515084)
- Testing
- PET, MRI imaging
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Henri Becquerel
Head and Neck Cancer
High Dose vs Low Dose I 131 +/- rhTSH for Differentiated Thyroid Cancer
RATIONALE: Radioactive iodine uses radiation to kill tumor cells. Giving iodine I 131 with or without thyroid-stimulating hormone after surgery may kill any tumor cells that remain after surgery.
- Trial name
- HiLo (NCT00415233)
- Testing
- recombinant thyroid-stimulating hormone, Radiodine ablation without rhTSH
- Where
- 25 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- University College, London
Hemifacial Microsomia, Mucormycosis
Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.
This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects.
- Conditions
- Hemifacial Microsomia, Mucormycosis, Oral Squamous Cell Carcinoma, Microgenia
- Trial name
- 3DFACE (NCT07654647)
- Testing
- Patient-specific titanium implants for facial reconstruction
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Latakia University
Head and Neck Squamous Cell Carcinoma
Nimotuzumab in Combination With TPF(Cisplatin ,Fluorouracil and Docetaxel) for Head and Neck Squamous Cell Carcinoma
Nimotuzumab (hR3) is an humanized monoclonal antibody that recognized an epitope located in the extra cellular domain of the human epidermal growth factor receptor (EGFR).
- Trial name
- NCT01425736
- Testing
- Chemotherapy, Nimotuzumab and Chemotherapy
- Where
- 5 sites in China
- Volunteers
- 91 people
- Sponsor
- Wei Guo
Head and Neck Cancer, Rehabilitation
Development and Evaluation of a Self-Management Model for Cancer Rehabilitation
Participants were primarily recruited from medical institutions, specifically targeting newly diagnosed patients with malignant tumors.
- Conditions
- Head and Neck Cancer, Rehabilitation, Psychotherapy
- Trial name
- NCT06674499
- Testing
- Self-help rehabilitation model, Conventional rehabilitation model
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Xingchen Peng
Tongue Neoplasms, Carcinoma
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than…
- Trial name
- NCT03288298
- Testing
- luteolin, nano-luteolin
- Volunteers
- 4 people
- Sponsor
- Cairo University
Head and Neck Cancer
Study Using the Medpulser Electroporation System With Bleomycin to Treat Head and Neck Cancer
The purpose of the trial is to study the safety and efficacy of the Medpulser Electroporation System with bleomycin in the treatment of head and neck cancer.
- Trial name
- NCT00198263
- Testing
- Medpulser Electroporation with Bleomycin
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Inovio Pharmaceuticals
Barrett Esophagus, Esophageal Neoplasm
ESD for the Treatment of Early Barrett's Neoplasia
This study assesses the quality of the resection of early neoplasia arinsing in Barrett's esophagus using endoscopic submucosal dissection.
- Trial name
- ESTEBAN (NCT02583087)
- Testing
- endoscopic submucosal dissection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hôpital Cochin
Cancer of Unknown Origin, Cancer Refractory
Genomic Testing and Resulting Medical Decisions
There is no evidence available about which molecular profiling methods are currently used for cancer patients in Austrian clinical practice.
- Conditions
- Cancer of Unknown Origin, Cancer Refractory, Cancer of Stomach, Cancer Head Neck
- Trial name
- NCT03301493
- Testing
- Genomic testing
- Where
- 11 sites in Austria
- Volunteers
- 1,500 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Papillary Thyroid Cancer
Molecular Analysis for Precision Surgery in Thyroid Cancer Trial
Ideal surgical extent for differentiated thyroid cancer remains unclear. Routine use of molecular analysis in biopsy-proven thyroid cancer could provide important prognostic information to help guide extent of surgery - thyroid…
- Trial name
- MAPS (NCT06235814)
- Testing
- Molecular Analysis for Thyroid Resection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, Los Angeles
Squamous Cell Carcinoma of the Head and Neck (SCCHN), Metastatic Castration Resistant Prostate Cancer (mCRPC)
Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors
Evaluation of the combination of avelumab + bempegaldesleukin (NKTR-214 ) in locally advanced squamous cell carcinoma of the head and neck ( metastatic SCCHN) and avelumab + bempegaldesleukin (NKTR-214) + talazoparib or…
- Trial name
- NCT04052204
- Testing
- avelumab, Bempegaldesleukin, talazoparib
- Where
- 5 sites in United States, Belgium and 2 more
- Volunteers
- 3 people
- Sponsor
- Pfizer
Esophageal Cancer
Tissue Oxygenation Are Associated With Anastomotic Leak Rates After an Ivor Lewis Esophagectomy
The purpose of this study is to test whether after an Ivor Lewis esophagectomy (the removal of a portion of the stomach and esophagus with re-attachment) there is an association between the intraoperative level of oxygen at the…
- Trial name
- NCT01551433
- Testing
- wireless pulse oximeter (Wipox)
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Cancer
Cisplatin and Radiation Therapy in Treating Patients With Stage IV Cancer of the Head and Neck
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002932
- Testing
- cisplatin, radiation therapy
- Where
- 13 sites in United States
- Volunteers
- 60 people
- Sponsor
- Radiation Therapy Oncology Group
Head and Neck Cancer
Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899704
- Testing
- microarray analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Neoplasms, Neoplasms
Autologous Tumor Tissue Antigen-sensitized DC-CIK Cells Combined With Chemotherapy for Esophageal Cancer
This study evaluates the safety and efficacy of D-CIK immune cells combined with chemotherapy after resection of esophageal cancer
- Conditions
- Esophageal Neoplasms, Neoplasms, Digestive System Neoplasms, Esophageal Cancer
- Trial name
- NCT02644863
- Testing
- Paclitaxel, DC-CIK, Cisplatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
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