Clinical trials: Head and Neck Tumours
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Thyroid Neoplasms
Minimize Radioactive Iodine Ablation Of Remnant Thyroid in Differentiated Thyroid Cancer
The researchers investigated the rate of biochemical remission in patients without radioactive iodine therapy compared to patients with low dose radioactive iodine treatment in differentiated thyroid cancer patients who underwent…
- Trial name
- NCT02418247
- Testing
- I131, I123
- Where
- 5 sites in South Korea
- Volunteers
- 556 people
- Sponsor
- National Cancer Center, Korea
Oesophageal Cancer
A Study of Donafenib Monotherapy in Advanced Oesophageal Cancer
This open-label, one-center, noncomparative, two-stages phase 1B trial assessed the tyrosine kinase inhibitor donafenib tosylate tablets(400 mg/d,200mg bid) in patients with advanced, inoperable oesophageal cancer progressing…
- Trial name
- NCT02489201
- Testing
- donafenib tosilate tablets
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Nasopharyngeal Carcinoma
Camrelizumab Combined With Apatinib in Patients With PD-1 Antagonists Resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
The purpose of this study is to explore the efficacy and safety of combination of Apatinib and Camrelizumab regimen in treating recurrent or metastatic nasopharyngeal carcinoma patients who were resistant to PD-1 antagonists.
- Trial name
- NCT04548271
- Testing
- Camrelizumab, Apatinib
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Sun Yat-sen University
Head and Neck Neoplasms
A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer
The main purpose of this study is to investigate the safety of prexasertib in combination with other anti-cancer drugs (cisplatin or cetuximab) and radiation therapy in participants with locally advanced head and neck cancer.
- Trial name
- NCT02555644
- Testing
- Prexasertib, Cisplatin, Cetuximab
- Where
- 4 sites in United States, France
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Head and Neck Cancer
Xerostomia in Head and Neck Cancer Patients Receiving Radiation as the Primary Treatment Versus Patients Who Will Not Have Such a Procedure
The purpose of this study is to compare the side effects of radiation treatment and surgery versus radiation alone, where no surgery is done to move the salivary gland and place it under the chin region where it can be shielded…
- Trial name
- NCT00168116
- Testing
- radiation treatment and surgery, radiation alone
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- AHS Cancer Control Alberta
Caregivers, Head and Neck Cancer
Feasibility of Internet Based Support (Carer eSupport) for Informal Caregivers of Patients With Head and Neck Cancer
Informal caregivers to patients with head and neck cancer report that they are unprepared for caregiving, that they experience a high caregiver burden and a deteriorated health.
- Conditions
- Caregivers, Head and Neck Cancer, Feasibility Study
- Trial name
- NCT05028452
- Testing
- Internet based support
- Where
- 4 sites in Sweden
- Volunteers
- 32 people
- Sponsor
- Uppsala University
Esophageal Squamous Cell Carcinoma
Fruquintinib as First Line Treatment in Patients With Recurrent Esophageal Squamous Cell Carcinoma
This Study is a Single-center, Single-arm, Phase II Clinical Study. The Primary Objective is to Evaluate the Efficacy and Safety of Fruquintinib, Carrelizumab, Paclitaxel Liposomes combined with Nidaplatin as First-line Treatment…
- Trial name
- NCT06010212
- Testing
- Fruquintinib Combined With Camrelizumab, Paclitaxel Liposome and Nedaplatin
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Esophageal Squamous Cell Carcinoma (ESCC)
Tumor Regression Grade As Predictor of Adjuvant Therapy
Neoadjuvant therapy followed by surgery is preferred for locally advanced esophageal squamous cell carcinoma, but the necessity of adjuvant therapy remains controversial.
- Trial name
- NCT06710665
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Cancer, Gastric Cancer
Fluorescence Image Guided Foregut Surgery
A high number of resected lymph nodes is an independent prognostic factor for improved survival after esophagectomy or gastrectomy for cancer.
- Trial name
- FOREGUT (NCT04734821)
- Testing
- Near Infra-Red Fluorescence Guided Surgery
- Where
- France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Head and Neck Cancer
Interest of Fluorescence in Salvage Surgery for Recurrence of Head and Neck Cancer in Irradiated Area
Treatment of Head and Neck Squamous cell carcinoma often combines chemoradiotherapy when organ has to be preserved or when surgery is not indicated. The loco-regional failure is about 30%.
- Trial name
- SALVADS-Fluo (NCT02920216)
- Testing
- indocyanine green
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut de Cancérologie de Lorraine
Esophageal Cancer, Quality of Life
Quality of Life After Esophagectomy for Cancer - Step 2
Background: A recent systematic review showed that patients undergoing esophagectomy for cancer had scores of physical function, vitality and performance of health in general significantly lower than those obtained from the…
- Trial name
- NCT01738633
- Testing
- nutritional counseling, respirology counseling
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Padova
Bladder Cancer, Cervical Cancer
Bupropion in Helping Adults Stop Smoking
RATIONALE: Bupropion may help people stop smoking by decreasing the symptoms of nicotine withdrawal. Giving bupropion over a longer period of time may be effective in helping people stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00534001
- Testing
- bupropion hydrochloride
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Roswell Park Cancer Institute
Advanced Cancer
A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)
This is a Phase 1b/2 dose-optimization study to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of avelumab (MSB0010718C) in combination with other cancer immunotherapies in patients with…
- Trial name
- NCT02554812
- Testing
- Avelumab, Utomilumab, PF-04518600
- Where
- 88 sites in United States, Australia and 6 more
- Volunteers
- 409 people
- Sponsor
- Pfizer
Oral Mucositis, Quality of Life
Retrospective Observational Study of Oral Complications and Quality of Life in Head and Neck Cancer Patients Treated With Radiotherapy or Chemoradiotherapy.
Head and Neck cancer patients receiving radiation therapy (with or without chemotherapy) suffer several oral complications, such as oral mucositis, which impairs quality of life of patients during radiotherapy and in the…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- NCT07739771
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Mucosa Innovations, S.L.
Brain Cancer, Head and Neck Cancer
Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy
This prospective imaging study is evaluating the feasibility of using the Halcyon 4.0 radiotherapy system for radiation therapy planning in patients with cancer.
- Conditions
- Brain Cancer, Head and Neck Cancer, Lung Cancer, Gastric Cancer
- Trial name
- Dragon (NCT05427214)
- Testing
- Halcyon 4.0 system
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Washington University School of Medicine
Thyroid Neoplasm, Goiter
A Trial Comparing Wound Drainage and Post-operative Complications With and Without the Use of EVICEL™ Fibrin Sealant in Thyroidectomy
Primary Objectives To compare the amount of post-operative wound drainage between the group of patients in which EVICEL™ spray is utilized (Arm A), and the group of patients in which an EVICEL™ placebo is utilized (Arm B).
- Trial name
- NCT01226914
- Testing
- EVICEL
- Volunteers
- 55 people
- Sponsor
- Medical University of South Carolina
Cancer of Head and Neck
Study to Compare the Effect of Two Different Types of Humidifier on the Endotracheal Tube Patency
60 post operative patients who are kept intubated overnight \& are spontaneously breathing will be either supplied humidified oxygen Heated Humidifier(HH) or conventional mist nebulizer.
- Trial name
- NCT02780765
- Testing
- heated humidifier, mist humidifier
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital
Carcinoma, Squamous Cell
Dose Escalation of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell Carcinoma of the Head and Neck or Esophagus
maximum tolerated dose (MTD), safety, pharmacokinetics, efficacy of bivatuzumab mertansine
- Trial name
- NCT02254044
- Testing
- bivatuzumab mertansine
- Volunteers
- 7 people
- Sponsor
- Boehringer Ingelheim
Papillary Thyroid Cancer
Image-guided Thermal Ablation vs. Lobectomy for Solitary Papillary Thyroid Microcarcinoma
To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma
- Trial name
- NCT06325787
- Testing
- thyroid lobectomy, image-guided thermal ablation
- Volunteers
- 1,021 people
- Sponsor
- Chinese PLA General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.