Clinical trials: Head and Neck Tumours
Radiation Dermatitis, Head and Neck Cancer
Deep Learning-based Classification and Prediction of Radiation Dermatitis in Head and Neck Patients
to develop a deep learning-based model to grade the severity of radiation dermatitis (RD) and predict the severity of radiation dermatitis in patients with head and neck cancer undergoing radiotherapy, so as to provide support…
- Trial name
- NCT05607225
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophageal Squamous Cell Carcinoma, Esophagectomy
Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years
To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophagectomy, Radiotherapy, Chemotherapy
- Trial name
- NCT05604950
- Testing
- Since the data were collected retrospectively, there were no interventions
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yongtao Han
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma
Registry Platform Gastric/Esophageal Cancer (SAPHIR)
The registry aims to collect and analyse information on the antineoplastic treatment of patients with metastatic esophageal, gastric or gastroesophageal junction cancer, treated in palliative intention in daily routine practice…
- Conditions
- Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma
- Trial name
- SAPHIR (NCT04290806)
- Testing
- Routine care as per site standard
- Where
- Germany
- Volunteers
- 1,900 people
- Sponsor
- iOMEDICO AG
Esophageal Squamous Cell Carcinoma (ESCC)
Risk of Esophageal Cancer Returning After Immunotherapy, Chemotherapy, and Surgery
This observational study aims to understand the risk of cancer returning after surgery in people with esophageal squamous cell carcinoma, a type of cancer of the food pipe.
- Trial name
- NCT07822906
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Cancer Hospital & Institute
Thyroid Diseases, Goiter
Thyroidectomy-specific Enhanced Recovery After Surgery (ERAS) Protocol
Thyroidectomy is generally considered a low-to-moderate risk operation; however, postoperative pain, nausea/vomiting, and prolonged hospital stays remain common issues.
- Conditions
- Thyroid Diseases, Goiter, Thyroid Neoplasms
- Trial name
- NCT07575243
- Testing
- Enhanced Recovery After Surgery protocol, Conventional perioperative care
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
Esophageal Squamous Cell Carcinoma
Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)
This is a phase 2 trial investigating the effect and safety of afatinib in previously treated recurrent or metastasic esophageal squamous cell carcinoma with EGFR overexpression or EGFR amplification.
- Trial name
- NCT03940976
- Testing
- Afatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Xerostomia, Mouth Dryness
Acupuncture for Prevention of Radiation-Induced Xerostomia
The goal of this clinical research study is to learn if acupuncture is effective in preventing xerostomia (dry mouth) in cancer patients who receive radiation treatment to the head and neck area.
- Conditions
- Xerostomia, Mouth Dryness, Nasopharyngeal Cancer
- Trial name
- NCT00430378
- Testing
- Acupuncture, Standard Care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Lymphoma, Metastatic Malignant Solid Neoplasm
Trigriluzole With Nivolumab and Pembrolizumab in Treating Patients With Metastatic or Unresectable Solid Malignancies or Lymphoma
This phase I trial studies the best dose and side effects of trigriluzole in combination with nivolumab and pembrolizumab in treating patients with solid malignancies or lymphoma that has spread to other places in the body or…
- Conditions
- Lymphoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Renal Cell Cancer
- Trial name
- NCT03229278
- Testing
- Enzyme Inhibitor Therapy, Laboratory Biomarker Analysis, Nivolumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rutgers, The State University of New Jersey
Hend and Neck Squamous Cell Carcinoma Locally Advanced Operable
Cetuximab+Zimberelimab in Combination With Cisplatin and Nab-paclitaxel in Resctable Head and Neck Squamous Cell Carcinoma
This study is a single arm phase ll trial including 52 patients with T2N2-3M0#T3-4N0-3M0 (III-V) head and neck squamous cell carcinoma(HNSCC) eligible forresection, who receive Cetuximab+ Zimberelimab combined with cisplatin and…
- Trial name
- CZCNRHNSCC (NCT06107114)
- Testing
- Cetuximab, Zimberelimab, Docetaxel
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Xuekui Liu
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Carcinoma, Squamous Cell of the Head and Neck
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Head and Neck Carcinoma
The purpose of this Phase 2 study is to investigate whether intravenous administration of REOLYSIN® therapeutic reovirus in combination with Paclitaxel and Carboplatin is effective and safe in the treatment of squamous cell…
- Trial name
- NCT00753038
- Testing
- REOLYSIN®, Carboplatin, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Oncolytics Biotech
Head and Neck Neoplasms, Congenital Abnormalities
3D Modeling of the Cervico-facial Region and Cranial Nerve Tractography: IMAG 2 ORL Project
3D modeling associated with the tracking of nerve fibers meets the needs of preoperative planning for tumors and cervico-facial congenital malformations.
- Trial name
- IMAG 2 ORL (NCT05763615)
- Testing
- Tractography MRI
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Mucositis
Cobiprostone for the Prevention of Oral Mucositis in Subjects With Head and Neck Cancer Receiving Concurrent Radiation and Chemotherapy
Treatment for head and neck cancer often involves a combination of chemotherapy and radiation. One of the unfortunate consequences of standard care for head and neck cancer is the development of painful mouth sores, known as oral…
- Trial name
- NCT02542215
- Testing
- Cobiprostone, Standard Care - Chemotherapy, Standard Care - Radiation
- Where
- 76 sites in United States
- Volunteers
- 47 people
- Sponsor
- Sucampo Pharma Americas, LLC
Non-Hodgkin Lymphoma, Hodgkin Lymphoma
Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
The goals of this study is to determine if nelfinavir can target Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in patients with certain cancers.
- Conditions
- Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Kaposi Sarcoma, Gastric Cancer
- Trial name
- NCT02080416
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Cancer
Digital Patient Education Platform in Head and Neck Cancer
Head and neck cancer is a disease that has a particular propensity for treatment-related morbidity. It is hypothesized that patients who are more involved in their care in hospital and who are actively provided with more…
- Trial name
- NCT05211778
- Testing
- Digital Education Group
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of British Columbia
Head and Neck Cancer, Recurrent Cancer
Safety and Superiority of Penicillamine in Radiosensitization of Recurrent Head and Neck Cancer
Our preclinical study confirmed that copper accumulation can lead to radioresistance in vitro and in vivo, and reducing the concentration of copper with copper chelator help to overcome radioresistance.
- Trial name
- NCT06103617
- Testing
- Penicillamine
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Head and Neck Squamous Cell Carcinoma
A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)
This is a phase 3 open-label, randomized, controlled, multicenter study to compare petosemtamab vs investigator's choice monotherapy in HNSCC patients for the second- and third-line treatment of incurable metastatic/recurrent…
- Trial name
- NCT06496178
- Testing
- Petosemtamab, Investigator's Choice
- Where
- 193 sites in United States, Argentina and 22 more
- Volunteers
- 621 people
- Sponsor
- Genmab
Locally Advanced Head and Neck Squamous Cell Carcinoma
A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood
The goal of this prospective, randomized, single-blind controlled clinical study is to explore the efficacy of maintenance therapy with Sintilimab after chemoradiotherapy in locally advanced head and neck squamous cell carcinoma.
- Trial name
- NCT06240689
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, fluorouracil, irinotecan hydrochloride, and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT01498289
- Testing
- FOLFOX regimen, docetaxel, fluorouracil
- Where
- 508 sites in United States
- Volunteers
- 213 people
- Sponsor
- SWOG Cancer Research Network
Head and Neck Cancer
Treatment of Head & Neck Cancer With Chemotherapy and Radiation
Two new cancer treatment drugs called targeted therapies will be added to standard treatment for head and neck cancer to see if an improvement can be made in the effectiveness of treatment for this type of cancer.
- Trial name
- NCT00392704
- Testing
- Bevacizumab, Erlotinib, Paclitaxel
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- SCRI Development Innovations, LLC
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