Clinical trials: Headache
Migraine Disorders
Evaluation of ALD403 (Eptinezumab) in the Prevention of Chronic Migraine
The purpose of this study is to assess the efficacy and safety of ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- PROMISE 2 (NCT02974153)
- Testing
- ALD403 (Eptinezumab)
- Where
- 144 sites in United States, Belgium and 11 more
- Volunteers
- 1,121 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine
Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines?
The purpose of this study is to determine if Rizatriptan, a migraine medication, lowers motion sickness in migraine sufferers.
- Trial name
- NCT00360282
- Testing
- Rizatriptan
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pittsburgh
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Migraine
Efficacy and Safety Study of Rimegepant for Migraine Prevention in Japanese Subjects (Japan Only)
This study is being conducted to evaluate the efficacy, safety, and tolerability of rimegepant in Japanese subjects for the prevention of migraine.
- Trial name
- NCT05399485
- Testing
- Rimegepant
- Where
- 44 sites in Japan
- Volunteers
- 496 people
- Sponsor
- Pfizer
Migraine Headache
Pilot Study of BOTOX for Migraine Headaches
The purposes of this study are to assess whether subjects treated with BOTOX will: 1. have a decrease in the frequency and intensity of migraine headaches 2. experience improvements in quality of life 3.
- Trial name
- NCT00850421
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- HealthPartners Institute
Traumatic Brain Injury (TBI)
Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI).
- Trial name
- NCT03314584
- Testing
- Transcranial Magnetic Stimulation, Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- VA Office of Research and Development
Migraine
Randomized Trial in Adult Participants With Acute Migraines
The purpose of this study is to test the safety and efficacy of BHV-3500 (zavegepant) versus placebo in the acute treatment of moderate or severe migraine.
- Trial name
- NCT04571060
- Testing
- Zavegepant
- Where
- 94 sites in United States
- Volunteers
- 1,978 people
- Sponsor
- Pfizer
Cyclic Vomiting Syndrome, Abdominal Migraine
Auricular Neurostimulation for Cyclic Vomiting Syndrome
This study evaluates the efficacy of auricular neurostimulation via an non-invasive percutaneous electrical nerve field stimulator in children and adults with cyclic vomiting syndrome.
- Trial name
- NCT03434652
- Testing
- Percutaneous neurostimulation
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Medical College of Wisconsin
Migraine
Study to Test a Marketed Product in the Treatment of Migraine-associated Nausea
Study to test the effectiveness of a marketed drug in the treatment of migraine-associated nausea.
- Trial name
- NCT00250458
- Testing
- Comparator: Rizatriptan
- Volunteers
- 346 people
- Sponsor
- Organon and Co
Episodic Migraine
The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache
Evidence-based medicine depends on distinguishing between pharmacological effects and placebo effects in randomized controlled trials (RCT).
- Trial name
- NCT00719134
- Testing
- Maxalt
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Beth Israel Deaconess Medical Center
Headache
Treatment of Post-dural Puncture Headache in Postpartum Patients: Sphenopalatine Ganglion Block to Epidural Blood Patch.
The purpose of this research study is to compare the effectiveness of a sphenopalatine ganglion block to an epidural blood patch for post-dural puncture headache relief in randomized postpartum parturients over a 48 hour period.
- Trial name
- NCT02962427
- Testing
- Sphenopalatine ganglion Block, Epidural blood patch
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver
Migraine in Adolescence
Real-world Data Analysis of REN Treatment in Adolescence With Migraine
This is a Post-marketing study investigating the safety and efficacy of the REN device (Nerivio by Theranica, Israel) in adolescents with migraine.
- Trial name
- NCT05443659
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 1,629 people
- Sponsor
- Theranica
Migraine, With or Without Aura
Open Label Safety Study in Acute Treatment of Migraine
The purpose of this study is to evaluate safety and tolerability of BHV-3000 (rimegepant).
- Trial name
- NCT03266588
- Testing
- Rimegepant
- Where
- 98 sites in United States
- Volunteers
- 3,019 people
- Sponsor
- Pfizer
Migraine
Greater Occipital Nerve Block Versus Metoclopramide
We are comparing a type of nerve block called greater occipital nerve block versus standard therapy among patients who present to an emergency department for acute migraine. This is a randomized, double-blind, double dummy study.
- Trial name
- NCT03269435
- Testing
- Greater occipital nerve block with bupivacaine, Metoclopramide
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Montefiore Medical Center
Migraine, Major Depressive Disorder
A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder
The primary objective is to evaluate the efficacy of monthly 225 mg sc fremanezumab in adult participants with migraine and major depressive disorder (MDD) The secondary objectives are to evaluate the efficacy of monthly 225 mg…
- Trial name
- NCT04041284
- Testing
- Fremanezumab
- Where
- 64 sites in United States, Czechia and 11 more
- Volunteers
- 353 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Disorders
Biomarker Study in Participants With Migraine
This is a study of participants with a diagnosis of migraine who completed another clinical trial NCT02163993. The participants received either LY2951742 or placebo.
- Trial name
- NCT02766517
- Testing
- Capsaicin
- Where
- 14 sites in United States
- Volunteers
- 37 people
- Sponsor
- Eli Lilly and Company
Migraine
An Efficacy and Tolerability Study of Topiramate in Participants With Migraine
The purpose of this study is to investigate the adequacy (reasonably good) of topiramate therapy (medicine or medical care given to a participant for a disease or condition) in prevention of migraine (type of severe headache that…
- Trial name
- NCT01060111
- Testing
- Topiramate Standard, Topiramate Slow, Propranolol booster
- Where
- 6 sites in South Korea
- Volunteers
- 250 people
- Sponsor
- Janssen Korea, Ltd., Korea
Migraine
A Research Study Examining the Use of Olanzapine for the Prevention of Migraine
Olanzapine (o-lan-zah-peen) is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of patients with schizophrenia and/ or bipolar disorder. The trade name for this drug is Zyprexa®.
- Trial name
- NCT00203307
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Thomas Jefferson University
Migraine Disorders
Chronic Migraine Epidemiology and Outcomes Study
This is a population internet-based study to characterize migraine clinical course and impact on family.
- Trial name
- NCT01648530
- Testing
- No Treatment
- Volunteers
- 16,789 people
- Sponsor
- Allergan
Acute Migraine
Migraine Treatment With Nerivio Migra Neurostimulation Device
This is a prospective, randomized, double-blind, sham controlled multi-center trial. Ratio between treatment and control groups will be 1:1, stratified by center and use of preventive medications.
- Trial name
- NCT03076515
- Testing
- Nerivio Migra neurostimulation
- Where
- 8 sites in United States, Israel
- Volunteers
- 120 people
- Sponsor
- Theranica