Clinical trials: Headache (Migraine)
Migraine
A Study of Gastrointestinal Emptying Time in Adult Participants With Migraine Before and After Start of a mAb CGRP Antagonist
The purpose of this study is to measure the gastrointestinal emptying time using the wireless motility capsule (WMC) technology (FDA approved SmartPill™) in adult participants with migraine who are taking a monoclonal antibody…
- Trial name
- NCT04294147
- Testing
- Galcanezumab, Erenumab
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Eli Lilly and Company
Migraine Headache
Safety and Tolerability of POD-DHE (INP104) in Migraine (STOP 301)
This study consists of a 4-week screening period, a 24-week treatment period for all participants, followed by a 28-week treatment period extension (to 52 weeks in total) for a subset of at least 60 and up to 80 participants, and…
- Trial name
- NCT03557333
- Testing
- INP104
- Where
- 36 sites in United States
- Volunteers
- 360 people
- Sponsor
- Impel Pharmaceuticals
Vestibular Migraine
Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine
The presented study aims to compare effectivity of propranolol with effectivity of venlafaxine in escalating dose in subjects with vestibular migraine (VM) over a period of 12 weeks.
- Trial name
- NCT02350985
- Testing
- Propranolol, Venlafaxine
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Haseki Training and Research Hospital
Migraine Headache
A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches
To study the effect of Rozerem, a high affinity MT1 and MT2, low affinity 5-HT2B receptor agonist used for insomnia, as a migraine prophylactic agent.
- Trial name
- NCT00391755
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Charlottesville Neuroscience
Migraine, Epilepsy
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine.
- Conditions
- Migraine, Epilepsy, Visual Snow Syndrome
- Trial name
- NCT05524493
- Testing
- Structural MRI, Quantitative MRI, Diffusion MRI
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine, Migraine With Aura
Gepant treAtments: EffectIveNess and tolERability (GAINER)
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as acute migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- GAINER (NCT05903027)
- Testing
- Rimegepant 75 MG Disintegrating Oral Tablet
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Chronic Pain, Migraine
Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment
The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain.
- Conditions
- Chronic Pain, Migraine, Chronic Pain Syndrome
- Trial name
- NCT07143396
- Testing
- Mind-body mobile application and guided movement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of the Fraser Valley
Human Volunteers, Migraine
A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately
The primary purpose of this open-label study is to determine if concomitant therapy with topiramate and flunarizine has any effect on the pharmacokinetics of either drug.
- Trial name
- NCT00752466
- Testing
- Topiramate; flunarizine
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine, Chronic Tension-Type Headache
Nurse Intervention Trial
This randomized open-label prospective study focus on headache patients initiating preventive treatment, where the treating physician identifies a need for follow-up visits in specialized healthcare.
- Conditions
- Migraine, Chronic Tension-Type Headache, Cluster Headache, Hemicrania Continua
- Trial name
- NCT06200480
- Testing
- Telephone by nurse
- Where
- Norway
- Volunteers
- 147 people
- Sponsor
- Norwegian University of Science and Technology
Migraine, Migraine With Aura
Monoclonal CGRP Antibodies for Migraine Prevention - a Nationwide Real Life Study
The present non-interventional study on migraine prevention with monoclonal CGRP antibodies adresses questions concering safety, swichting from one CGRP mab to another, efficacy on auras in the real world setting.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- NCT05281770
- Testing
- Erenumab, Fremanezumab, Galcanezumab
- Where
- 3 sites in Austria
- Volunteers
- 1,500 people
- Sponsor
- Austrian Migraine Registry Collaboration
Migraine
The MOTS (Medication Overuse Treatment Strategy) Trial
There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.
- Trial name
- MOTS (NCT02764320)
- Testing
- Migraine Prophylactic Therapy Only, Discontinuation of Overused Medication
- Where
- 29 sites in United States
- Volunteers
- 720 people
- Sponsor
- Mayo Clinic
Migraine
A Study Investigating the Movement of Lu AG09222 Into, Through, and Out of the Body of Healthy Caucasian, Chinese, and Japanese Participants
The main goal of the study is to learn more about how the body absorbs and eliminates Lu AG09222 after a single dose is injected under the skin.
- Trial name
- NCT05304910
- Testing
- Lu AG09222
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Rhinitis
Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application
The purpose of this study is to study interactions between genes, lifestyle environmental factors like foods, nutritional supplements and non-invasive medical devices and health factors that can be measured without specialized…
- Conditions
- Obesity, Rhinitis, Rhinitis, Allergic, Respiratory Sounds
- Trial name
- NCT02758990
- Testing
- Vitamin A, Vitamin B6, Vitamin C
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Verifomics LLC
Headache, Migraine
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
- Trial name
- NCT00957983
- Testing
- BGC20-1531
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Shoulder osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Shoulder Osteoarthritis
- Trial name
- NCT07347054
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Migraine Disorders
Dose-ranging Study of Oral COL-144 in Acute Migraine Treatment
The purpose of this study is to evaluate the efficacy and safety of a range of oral doses of COL-144 in treating migraine headache, in order to select a dose or doses for further evaluation.
- Trial name
- NCT00883051
- Testing
- Lasmiditan
- Where
- 39 sites in Belgium, Finland and 3 more
- Volunteers
- 512 people
- Sponsor
- Eli Lilly and Company
Migraine
Probiotics for the Prophylaxis of Migraine
This study aims to understand the efficacy of two probiotic interventions as prophylaxes of migraine symptoms in individuals diagnosed with episodic migraine.
- Trial name
- MIGR_PRO2 (NCT04305522)
- Testing
- Probiotic 1, Probiotic 2
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Biopolis S.L.
Migraine Disorders
BI 44370 TA in Acute Migraine Attack
The objective of this trial is to assess the safety, tolerability, and efficacy of three doses of BI 44370 TA in the treatment of patients with an acute migraine attack and headache pain of moderate or severe intensity, compared…
- Trial name
- NCT00751803
- Testing
- BI 44370 TA Low Dose, Eletriptan, BI 44370 TA Medium Dose
- Where
- 52 sites in Belgium, El Salvador and 7 more
- Volunteers
- 416 people
- Sponsor
- Boehringer Ingelheim
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
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