Clinical trials: Headache (Migraine)
Migraine Without Aura
Multiparametric Diagnostic Model of Thick-section Clinical-quality MRI Data in Detecting Migraine Without Aura
Recently, radiomics combined with machine learning method has been widely used in clinical practice. Compared with traditional imaging studies that explore the underlying mechanisms, the machine learning method focuses on…
- Trial name
- NCT03570086
- Testing
- diagnostic
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xidian University
Migraine
Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis
To investigate efficacy and safety of a supplementation with a fixed combination of magnesium, vitamin B2, feverfew, andrographis paniculata and coenzyme Q10 (Vivinor®) in episodic migraine prevention, by an observational…
- Trial name
- NCT04463875
- Testing
- magnesium, vitamin B2, feverfew, andrographis paniculata and coenzyme Q10
- Where
- Greece
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Corfu Headache Clinic
Inflammation, Migraine
Inflammatory Markers Identification in Migraine Patients
Migraine is prevalent in 10-12% of the population. It involves the development of a cranial perivascular neurogenic inflammation. Recent information suggests that migraine might be a risk factor to stroke.
- Conditions
- Inflammation, Migraine, Headache
- Trial name
- NCT01618201
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Migraine Disorders, Chronic Disease
"Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine
There is no doubt that chronic migraine is a large public health problem, which is both disabling and costly. Many patients and headache doctors see Botulinum toxin (Botox) treatment as a big stride forward, but it is a problem…
- Trial name
- NCT03543254
- Testing
- BoNT-A
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Migraine Headache, Sleep
Light Exposure, Migraine Outcomes, and Sleep Quality
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.
- Conditions
- Migraine Headache, Sleep, Photophobia
- Trial name
- NCT07476053
- Testing
- Ambient Lighting Condition
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Arizona State University
Migraine Disorders
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism…
- Trial name
- NCT05690737
- Testing
- Tai Chi training, Standard prophylactic medication
- Where
- 2 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The Hong Kong Polytechnic University
Post Traumatic Headache
Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT)
Most individuals with mild traumatic brain injury (mTBI) experience post-traumatic headaches (PTH). Of PTH, 50% present with a migraine phenotype which is the most disabling type of PTH.
- Trial name
- NCT07191145
- Testing
- Eptinezumab
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Migraine, Medication Overuse Headache
A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache
Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat a headache or migraine once it begins).
- Trial name
- RESOLUTION (NCT05452239)
- Testing
- Eptinezumab
- Where
- 76 sites in United States, Australia and 9 more
- Volunteers
- 608 people
- Sponsor
- H. Lundbeck A/S
Migraine Headache With Intractable Migraine
Ketamine for Refractory Chronic Migraine: a Pilot Study
Ketamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic…
- Trial name
- NCT03896256
- Testing
- ketamine infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Thomas Jefferson University
Migraine
A Study to Learn About the Benefit of Rimegepant Versus Triptans in Migraine Buddy App Users.
The purpose of this study is to collect information of the US users from the Migraine Buddy app between 20 October 2023 and 20 May 2024.
- Trial name
- NCT06532357
- Where
- United States
- Volunteers
- 1,536 people
- Sponsor
- Pfizer
Migraine
A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments
The purpose of this trial is to determine which doses of Lu AG09222 are recommended to help prevent migraines. People who join this trial have already tried 1 to 4 other available medications to prevent their migraines, but these…
- Trial name
- PROCEED (NCT06323928)
- Testing
- Lu AG09222
- Where
- 120 sites in United States, Bulgaria and 12 more
- Volunteers
- 874 people
- Sponsor
- H. Lundbeck A/S
Migraine Disorders
Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas as Well as Subnuclei of the Spinal Trigeminal Nucleus
In previous studies clustering of the three branches of the trigeminal nerve in brainstem were shown, cerebellum and periaqueductal gray.
- Trial name
- NCT06535880
- Testing
- Electric Current Stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Headache, Migraine
Headache and Hormone Use Among Transgender Population in Thailand: A Cross-Sectional Online Study
The goal of this observational study is to learn how common headache and migraine are and to describe headache patterns among transgender adults in Thailand.
- Trial name
- H-TRANS (NCT07817446)
- Testing
- gender-affirming hormone therapy, Gender-Affirming Surgery, HIV Pre-Exposure Prophylaxis
- Where
- Thailand
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Primary Headaches (Includes Migraines, Tension, Cluster Headaches)
Personalised Process-based Psychological Interventions for Paediatric Headaches
This project was an empirical single-case experimental design (SCED) study conducted as part of a DClinPsy doctoral thesis completed by one of the researchers.
- Trial name
- HEAD-FLEX (NCT07418723)
- Testing
- PBT Personalised
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Royal Holloway University
Migraine Without Aura, Unilateral Headache
Acupuncture for Migraine Prophylaxis
Hypothesis: Acupuncture obtains an abiding effect on migraine prophylaxis Design: A open-label randomized controlled trial. 249 participants will be included.
- Trial name
- AMP (NCT01687660)
- Testing
- acupuncture
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Li ying
Migraine
A Trial Investigating Lu AG09222 With Ubrogepant in Participants With Migraine
The main goal of this trial is to learn more about the safety and tolerability of Lu AG09222 when taken together with ubrogepant.
- Trial name
- NCT06578585
- Testing
- Ubrogepant, Lu AG09222
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- H. Lundbeck A/S
Central Post-stroke Pain
Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders
The goal of this observational study is to examine the association between exact lesion location and presence of thalamic CPSP (Central post-stroke pain) in a larger number of patients after thalamic stroke.
- Trial name
- NCT05679297
- Testing
- Quantitative sensory testing (QST), Magnetic resonance imaging (MRI), Clinical interview/exam
- Where
- Switzerland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Migraine, Treatment
Facilitators and Barriers to Eptinezumab Administration in Thailand
This research study is designed as a longitudinal prospective descriptive study using mixed-method data collection. Eptinezumab, an anti-calcitonin gene-related peptide monoclonal antibody (anti-CGRP mAb), is administered by…
- Conditions
- Migraine, Treatment, Treatment Refusal
- Trial name
- FACEpi (NCT07035197)
- Testing
- Eptinezumab
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Migraine
Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients
This study is testing an investigational inhaled migraine medication to see how well it works, how safe it is, and how well people tolerate it.
- Trial name
- NCT07646613
- Testing
- ASY202
- Where
- 20 sites in United States
- Volunteers
- 108 people
- Sponsor
- Aspeya, Inc.
Migraine, With or Without Aura
Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine
This study will evaluate the efficacy, safety, and tolerability of 2 doses of ubrogepant (50 and 100 mg) compared to placebo for the acute treatment of a single migraine attack.
- Trial name
- ACHIEVE I (NCT02828020)
- Testing
- Ubrogepant
- Where
- 90 sites in United States
- Volunteers
- 1,672 people
- Sponsor
- Allergan
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