Clinical trials: Headache (Migraine)
Migraine Disorders
Transcranial Direct Current Simulation in Chronic Migraine
This study is a pilot, double-blind, placebo-controlled, randomized trial aiming to compare the effects of transcranial direct current stimulation in Chronic Migraine.
- Trial name
- NCT02817139
- Testing
- TDCS
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Paraíba
Migraine Disorders
Efficacy, Safety, Tolerability and Pharmacokinetics of BIBN 4096 BS Versus Placebo in the Treatment of a Single Attack of Acute Migraine Headache
Efficacy, Safety, Tolerability and Pharmacokinetics of BIBN 4096 BS in patients with a single acute migraine attack with or without aura
- Trial name
- NCT02198339
- Testing
- BIBN 4096 BS
- Volunteers
- 126 people
- Sponsor
- Boehringer Ingelheim
Migraine
A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
The purpose of this study is to assess the safety and effectiveness of topiramate as compared to placebo for the prevention of headaches in patients with chronic migraine.
- Trial name
- NCT00210912
- Testing
- topiramate
- Volunteers
- 328 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine Headache
Zomig - Treatment of Acute Migraine Headache in Adolescents
The purpose of this study is to investigate if Zomig® Nasal Spray will help children (age 12-17 years) with migraine headaches feel better.
- Trial name
- TEENZ (NCT01211145)
- Testing
- Zolmitriptan
- Where
- 74 sites in United States, Estonia and 6 more
- Volunteers
- 1,653 people
- Sponsor
- AstraZeneca
Refractory Migraine
Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment Phase 1
The goal of this clinical trial is to test whether injecting lidocaine and steroids into two blood vessels of the brain can help treat chronic headaches (migraines).
- Trial name
- LIGHT 1 (NCT06462781)
- Testing
- Lidocaine hydrochloride, Methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cooper Health System
Migraine
A Study of Wearable Devices to Predict Migraines
The purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse).
- Trial name
- NCT05755945
- Testing
- eHealth Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Migraine, Migraine Headache
Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine
The purpose of this migraine prevention study is to evaluate the efficacy and safety of AST-726 in moderate to severe migraine patients at one of two doses compared to placebo and compared to a baseline period as measured by a…
- Conditions
- Migraine, Migraine Headache, Migraine Disorders, Migraine With Aura
- Trial name
- NCT00285402
- Testing
- AST-726 Low dose, AST-726 High dose
- Where
- 19 sites in Finland, Netherlands and 1 more
- Volunteers
- 198 people
- Sponsor
- Ariston Pharmaceuticals, Inc.
Migraine Without Aura, Migraine With Aura
Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study
Evaluation of headache response at 2 hours for active treated attacks for increasing dose.
- Trial name
- NCT01859481
- Testing
- Eletriptan HBr 40 mg, Eletriptan HBr 80 mg
- Where
- 148 sites in Belgium, Czechia and 12 more
- Volunteers
- 971 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Headache, Migraine
Comparison of a Drug and Placebo in the Prevention of Migraine Headaches
The purpose of this study is to determine whether ethosuximide works better than placebo in the prevention of episodic migraine among veterans.
- Trial name
- NCT01122381
- Testing
- ethosuximide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- US Department of Veterans Affairs
Migraine Disorders
A Study of LY2951742 in Healthy Japanese and Caucasian Participants
The main purpose of this study is to evaluate the safety of the study drug known as LY2951742 in healthy Japanese and Caucasians. The study will also investigate how the body processes the drug and how the drug affects the body.
- Trial name
- NCT02104765
- Testing
- LY2951742
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine
Telcagepant (MK-0974) Long-Term Safety Study in Adult Participants With Acute Migraine (MK-0974-012)
The purpose of this study is to investigate the safety and tolerability of telcagepant (MK-0974) in the long-term treatment of acute migraine in adult participants.
- Trial name
- NCT00443209
- Testing
- Telcagepant 300 mg soft gel capsules, Telcagepant 280 mg tablets, Rizatriptan 10 mg tablets
- Volunteers
- 1,068 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
The Effect of Nasal Carbon Dioxide (CO2) in the Treatment of Mild Headache in People Who Experience Migraines
The purpose of this study is to evaluate the safety and effect of nasal carbon dioxide in the treatment of mild headaches in people who have migraines.
- Trial name
- NCT00690716
- Testing
- Nasal CO2
- Where
- 15 sites in United States
- Volunteers
- 292 people
- Sponsor
- Capnia, Inc.
Migraine in Children, Migraine With Aura
Mindfulness for Adolescents for CM and HFEM
Chronic Migraine (CM) and High Frequency Episodic Migraine (HFEM) without Aura affect adolescents' lives in terms of reduced health, reduced ability to perform daily chores and reduced quality of life.
- Trial name
- MINDKIDS (NCT04968093)
- Testing
- Mindfulness-based therapy.
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Migraine
STOP PAIN: Septal Closure of PFO - Does it Prevent Migraine?
The primary objective of this Study is to compare the effect of transcatheter device closure of atrial shunting to a non-closure control group over a period from cessation of procedure related medication at 3 months until 9…
- Trial name
- NCT00369499
- Testing
- PFO Closure
- Where
- Germany
- Volunteers
- 656 people
- Sponsor
- Abbott Medical Devices
Headache, Migraine
Adolescent Lifestyle Medicine Headache Study
The goal of this pilot clinical trial is to assess the implementation of a 7-week Lifestyle Medicine intervention for adolescents with headache.
- Trial name
- NCT07373275
- Testing
- Lifestyle Medicine Group Medical Visits
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Migraine Headache
Relief of Migraine Pain Through Electro Stimulation
This study will evaluate transcutaneous electro stimulation device developed by Siano for adequacy, safety and efficacy for the treatment and/or prevention of migraine pain for migraine sufferers.
- Trial name
- NCT02453399
- Where
- Israel
- Volunteers
- 87 people
- Sponsor
- Theranica
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Acute Migraine
Safety and Efficacy of ZP-Zolmitriptan Intracutaneous Microneedle Systems for the Acute Treatment of Migraine
This is a randomized, double-blind, multi-center, parallel-group study designed to compare the safety and efficacy of a range of doses of ZP-Zolmitriptan intracutaneous microneedle systems to placebo.
- Trial name
- Zotrip (NCT02745392)
- Testing
- ZP-Zolmitriptan
- Where
- 36 sites in United States
- Volunteers
- 365 people
- Sponsor
- Zosano Pharma Corporation
Migraine
Adherence to and Beliefs on Recommendations for Behavioral Treatment for Migraine
Migraine patients are oftentimes referred for evidence based behavioral therapies to prevent migraine. Yet, at follow-up visits, they report not seeing the behavioral therapist.
- Trial name
- NCT03799211
- Testing
- Motivational Interviewing, Treatment as Usual
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NYU Langone Health
Migraine
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
The purpose of this study is to determine the receptor occupancy (RO) associated with telcagepant (MK-0974) administration based on displacement of [11C]MK-4232 from the CGRP receptors in the brain using PET.
- Trial name
- NCT01315847
- Testing
- telcagepant, [11C]MK-4232
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
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