Clinical trials: Headache (Migraine)
Migraine, Tension Type Headache
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population
This study is an interventional trial to evaluate the effectiveness of a cognitive and physical program (Intervention), in reducing the frequency of head and neck pain in the population of an extensive territory of Italy.
- Conditions
- Migraine, Tension Type Headache, Cervical Pain
- Trial name
- NCT01050972
- Testing
- Behavioral: Cognitive, Relaxation, Exercise Therapy
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Migraine Without Aura
PACAP27 Headache Properties in Migraine Without Aura Patients
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a signaling molecule, localized in sensory and parasympathetic perivascular nerves fibres.
- Trial name
- NCT03471039
- Testing
- PACAP27, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Physiotherapy Intervention for Migraine Symptoms
The goal of this randomized control trial is to analyse the effectiveness of Physiotherapy intervention among university students with migraine symptoms. The main objective is: 1.
- Trial name
- NCT05741775
- Testing
- Aerobic training, Biofeedback Training
- Where
- Malaysia
- Volunteers
- 87 people
- Sponsor
- Universiti Tunku Abdul Rahman
Chronic Migraine, Headache
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- Trial name
- NCT07512219
- Testing
- Greater occiptal nerve block, Pulsed radiofrequency
- Volunteers
- 70 people
- Sponsor
- Sohag University
Headache, Migraine
Investigation of Vasodilation and Intensity of Headache Triggered by Glucagon Like Peptide-1 in Humans
Studying glucagon-like peptide-1 (GLP-1) induced vasodilatory effects on extra - and intracerebral arteries and headache in healthy volunteers and migraine patients without aura.
- Trial name
- NCT04232605
- Testing
- GLP-1 peptide
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Trans-diagnostic Cognitive-behavioral Therapy for Treatment of Migraine
Migraine headache is one of the disabling conditions that may be associated with decreased quality of life, anxiety and depression.
- Trial name
- NCT03701477
- Testing
- Trans-diagnostic cognitive-behavioral therapy, General relaxation/stress management therapeutic session
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Isfahan University of Medical Sciences
Migraine, Upper Extremity
Scapular Muscle Activation and Shoulder Performance in Migraine
Migraine is a significant health problem due to its high prevalence and substantial contribution to disability. Individuals with migraine have been reported to exhibit myofascial trigger points, increased pain sensitivity, and…
- Conditions
- Migraine, Upper Extremity, Muscle Activity
- Trial name
- NCT07656922
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Migraine
Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department
This is a pilot feasibility acceptability study to examine the impact of smartphone-based progressive muscle relaxation (PMR) on migraine quality of life, frequency, intensity, and disability.
- Trial name
- NCT04281030
- Testing
- PMR (Progressive muscle relaxation therapy), Monitored Usual Care (MUC)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- NYU Langone Health
Migraine
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.
- Trial name
- REJOIN (NCT05164172)
- Testing
- Eptinezumab
- Where
- 64 sites in United States, Argentina and 9 more
- Volunteers
- 600 people
- Sponsor
- H. Lundbeck A/S
Migraine
Effectiveness of Manual Lymphatic Drainage in the Physiotherapeutic Treatment of Migraine
Migraine is a highly prevalent neurological disorder associated with recurrent headache, disability, and reduced quality of life.
- Trial name
- EDLMMG (NCT07425041)
- Testing
- Manual lymphatic drainage
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Camilo Jose Cela University
Acute Migraine
Efficacy and Safety of Acetaminophen and Aspirin Versus Placebo in the Acute Treatment of Migraine
The purpose of the study is to evaluate the efficacy and safety of acetaminophen and aspirin versus placebo in the acute treatment of migraine
- Trial name
- NCT01973205
- Testing
- Acetaminophen 250 mg and Aspirin 250 mg
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- Novartis
Migraine
Efficacy and Safety of Oral NBP Soft Capsules for the Prevention of Episode Migraine Attacks in Adult Migraine Patients
This is a multicentre, randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety and tolerability of oral butylphthalide soft capsules for the prophylactic treatment of migraine in adults.
- Trial name
- ENERGY (NCT06968429)
- Testing
- NBP Softgel Capsules
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Headache, Migraine
PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers
Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known…
- Trial name
- NCT00291395
- Testing
- PGI2
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine, Headache
Amitriptyline vs GON and SON Blocks in Migraine
Comparison of efficacy and safety of amitriptyline and nerve blocks
- Trial name
- NCT04750967
- Testing
- Lidocaine 1% Injectable Solution, Amitriptyline
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Migraine
Long-term Safety and Tolerability of Subcutaneous Administration of TEV-48125 for the Preventive Treatment of Migraine
To evaluate the long-term safety and tolerability of subcutaneous (SC) administration of TEV-48125 (at 225 mg once monthly [except for a loading dose of 675 mg for CM patients] or at 675 mg every 3 months) for the preventive…
- Trial name
- NCT03303105
- Testing
- TEV-48125
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Chronic Headache, Migraine
Assessment of the Effectiveness of Virtual Reality as a Learning Tool for Relaxation Techniques in Reducing Pediatric Migraines and Tension Type Headache
The goal of this interventional study is to assess the efficacy of a therapeutic intervention aimed at diminishing pediatric chronic headache.
- Conditions
- Chronic Headache, Migraine, Tension Type Headache
- Trial name
- NCT06921109
- Testing
- Experimental: Relaxation training with VR, Experimental: Relaxation training without VR, No Intervention: Control group
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University of Liege
Migraine, Migraine Disorders
Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack
People with migraine typically show impaired responsivity to visual, auditory and pain stimuli (Burstein et al, 2015). The electrophysiological study of the nociceptive blink reflex (nBR) is widely adopted for the instrumental…
- Conditions
- Migraine, Migraine Disorders, Pain
- Trial name
- NCT05718310
- Testing
- Nitroglycerin, Saline
- Where
- 2 sites in Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine Headache
Study in Participants With Acute Migraines Headaches
This is a Phase 2, multicenter, randomized, double-blind, placebo and active comparator-controlled study of LY2590443 in approximately 200 participants with migraines.
- Trial name
- NCT00804973
- Testing
- LY2590443, Sumatriptan
- Where
- 19 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (Prodrome pre-headache) that a…
- Trial name
- NCT00846495
- Testing
- topiramate, frovatriptan
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Clinvest
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