Clinical trials: Headache Disorder
- Condition Headache Disorder
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Migraine Headache
Study in Participants With Acute Migraines Headaches
This is a Phase 2, multicenter, randomized, double-blind, placebo and active comparator-controlled study of LY2590443 in approximately 200 participants with migraines.
- Trial name
- NCT00804973
- Testing
- LY2590443, Sumatriptan
- Where
- 19 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Sleep Bruxism, Tension Headache
Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance
To determine the effectiveness of the Luco Hybrid OSA Appliance in the treatment of sleep bruxism and to aid in the treatment of associated tension/migraine type headaches in adults.
- Conditions
- Sleep Bruxism, Tension Headache, Migraine Headache
- Trial name
- LucoHybrid (NCT02882880)
- Testing
- The Luco Hybrid OSA Appliance
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Luco Hybrid OSA Appliance Inc.
Migraine
Bioavailability of Variably Aged MK-0974 Tablets (MK-0974-038)(COMPLETED)
This study will evaluate the comparative bioavailability of three capsule formulations of MK-0974.
- Trial name
- NCT01209741
- Testing
- telcagepant potassium, MK-0974 5Mo5C, MK-0974 12Mo5C
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Respiratory Tract Infections
To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine
This study is designed to assess bioequivalence between two paracetamol/ phenylephrine combination products.
- Trial name
- NCT01112462
- Testing
- Paracetamol 500 mg/Phenylephrine 5 mg tablets, Paracetamol 1000 mg/Phenylephrine 10 mg sachet
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McNeil AB
Tension Headaches, Stress
Temple Massager System Study in Women Ages 35-65
The goal of this observational study is to learn how the Temple Massager System affects stress, emotional wellbeing, sleep, and quality of life in women aged 35 to 65.
- Conditions
- Tension Headaches, Stress, Sleep Quality, Quality of Life
- Trial name
- NCT07639658
- Testing
- Temple Massager System
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Meisch Temple Massager, Inc.
Migraine
A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder
This study is an open-label, parallel group study to evaluate acute pulmonary safety and Pharmacokinetics (PK) of two doses, separated by 2 hours, of CVT-427 zolmitriptan inhalation powder in three groups of adults: those with…
- Trial name
- NCT02905227
- Testing
- CVT-427 (zolmitriptan inhalation powder)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acorda Therapeutics
Migraine
Bioequivalency Study of Naratriptan Hydrochloride 2.5 mg Under Fasted Conditions
The objective of this study was to prove the bioequivalence of Naratriptan Hydrochloride Tablet under fasted conditions.
- Trial name
- NCT01161667
- Testing
- naratriptan hydrochloride
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Migraine
Ascending Multiple-Doses of Erenumab (AMG 334) in Healthy Adults and in Migraine Patients
The primary purpose of this study is to determine whether erenumab is safe and well tolerated in healthy adults and migraine patients.
- Trial name
- NCT01723514
- Testing
- Erenumab
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Amgen
Migraine
Comparative Bioavailability Study of Omexa Sumatriptan vs. Imitrex® in Healthy Volunteers
the trial is a randomized, open label, crossover, single-administration bioavailability study to compare the pharmacokinetic parameters of Omexa sumatriptan transmucosal sublingual tablet versus commercial Imitrex® sumatriptan…
- Trial name
- NCT02954276
- Testing
- Omexa Sublingual Sumatriptan tablet, Imitrex Oral Product
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Targia Pharmaceuticals Ltd.
Headache, Migraine
Erenumab (AMG 334) Plus Combined Oral Contraceptive Drug Interaction Study in Healthy Females
A pharmacokinetic drug interaction study of erenumab and an oral contraceptive containing progestin and estrogen.
- Trial name
- NCT02792517
- Testing
- Erenumab, Ethynil Estradiol/Norgestimate Oral Contraceptive
- Where
- 4 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Amgen
Fever, Headache Disorders
Pharmacokinetic Study to Compare Two Formulations of Paracetamol
A pharmacokinetic study in healthy volunteers comparing two formulations of paracetamol fast release in fasted state.
- Conditions
- Fever, Headache Disorders, Pain
- Trial name
- NCT01767428
- Testing
- Paracetamol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine
Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine
This is a prospective, randomized, vehicle-controlled, double-blind, multi-center study assessing the safety, tolerability, and efficacy of B244 delivered as an intranasal spray for preventive treatment in subjects with episodic…
- Trial name
- NCT03488563
- Testing
- B244, Vehicle
- Where
- 22 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
Migraines
A Study of LY2951742 in Healthy Volunteers
To evaluate the safety and tolerability of LY2951742 given as single or multiple subcutaneous injection in healthy male subjects
- Trial name
- NCT01337596
- Testing
- LY2951742
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine, Patent Foramen Ovale
GORE® CARDIOFORM Septal Occluder Migraine Clinical Study
Multi-center, prospective, randomized, placebo- and sham-controlled study to evaluate the GORE® CARDIOFORM Septal Occluder for migraine headache relief
- Conditions
- Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
- Trial name
- RELIEF (NCT04100135)
- Testing
- Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel)
- Where
- 15 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Migraine
A Study to Learn About PRT-064040 Nasal Spray in Healthy Adult Subjects
This trial is a Phase I, single-center, randomized, double-blind, placebo-controlled study conducted in healthy Chinese adult subjects.
- Trial name
- NCT07016516
- Testing
- PRT-064040 nasal spray
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sichuan Purity Pharmaceutical Technology Co., Ltd.
Migraine
Aimovig Pregnancy Exposure Registry
The primary objective of this study is to estimate the proportion of major congenital malformations in infants of women with migraine exposed to erenumab-aooe during pregnancy compared to infants of women with migraine unexposed…
- Trial name
- NCT06150781
- Testing
- erenumab-aooe
- Where
- United States
- Volunteers
- 2,842 people, healthy volunteers welcome
- Sponsor
- Amgen
Pain, Migraine Disorders
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study Of PF-04427429 In Healthy Women Volunteers
The purpose of this study is to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-04427429 in healthy women.
- Trial name
- NCT01511497
- Testing
- PF-04427429, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pfizer
Migraine
Safety, Tolerability and Pharmacokinetics of ALD1910 in Healthy Men and Woman
The purpose of this study is to determine the safety, tolerability and pharmacokinetics of ALD1910, a monoclonal antibody, administered by intravenous infusion and subcutaneous injection.
- Trial name
- NCT04197349
- Testing
- ALD1910, Sumatriptan
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Migraine, Headache
Improvement of Migraine Severity and Frequency With Migraineguard ™
Numerous treatments have been recommended for the prevention of migraine. The purpose of this randomized double-blind placebo controlled trial was to assess the efficacy of MIGRAINEGUARD ™ supplement by Herbacure Natural…
- Trial name
- NCT04759040
- Testing
- Migraineguard
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Herbacure Natural
Migraine With Aura, Migraine Without Aura
A Phase I Study to Study the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects
Single-center, single-dose, open-label, 2-part, 3-period crossover (in each part), pharmacokinetic and safety study.
- Conditions
- Migraine With Aura, Migraine Without Aura, Migraine
- Trial name
- NCT03874832
- Testing
- Dihydroergotamine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Satsuma Pharmaceuticals, Inc.