Clinical trials: Headache Disorder
Subarachnoid Hemorrhage in Adult Patients
Sphenopalatine Block in Headache in Patients With Non-traumatic Subarachnoid Hemorrhage
Non-traumatic SAH, linked in 85% of cases to the rupture of an intracranial aneurysm, is a serious stroke affecting young people. Half of all survivors suffer cognitive impairment.
- Trial name
- SATURN (NCT06735261)
- Testing
- Sphenopalatine Ganglion Block using 2% lidocaine
- Volunteers
- 70 people
- Sponsor
- University Hospital, Grenoble
Migraine Disorders, Chronic Migraine
Biochemical Profiling of Migraine Patients
Aim of the study was to assess a potential dysfunction of the endocannabidiome system (eCBome) in migraine patients. Migraine patients who will undergo preventive therapy with monoclonal antibodies directed against the calcitonin…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_1 (NCT06549270)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Tension-Type Headache
Effcet of Temporomandibular Joint Disorder Relaxation and Myofacial Relaxation Techniques on Tension Headache
The aim of this course is to investigate the effect of temporomandibular joint relaxation and myofacial relaxation techniques on quality of life , Joint range of motion, headache, depression in individuals with tension type…
- Trial name
- NCT05058573
- Testing
- Control group (n=22)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Alanya Alaaddin Keykubat University
Postdural Puncture Headache
Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Emergency Department
This study evaluates sphenopalatine ganglion block (SPGB) for the treatment of postdural puncture headache (PDPH) in the emergency department (ED).
- Trial name
- NCT02517931
- Testing
- Sphenopalatine Ganglion Block
- Where
- United States
- Sponsor
- University of Arkansas
Cervicogenic Headache
Diclofenac Gel in the Treatment of Cervicogenic Headache
The intervention will consist of the nursing staff applying 2 grams of diclofenac 1% gel topically to the posterior cervical region four times daily.
- Trial name
- DITCH (NCT05312645)
- Testing
- Diclofenac 1% Topical, Petroleum Jelly
- Where
- United States
- Sponsor
- Loma Linda University
Migraine, Sleep Disorder (Disorder)
Sleep, Stress and Migraine - an Observational and Training Study
The MiSleepS study investigates how sleep disturbances and stress are linked to migraine attacks. Participants wear a device called a WHOOP band, which tracks sleep and body signals, and answer brief daily questions via a…
- Conditions
- Migraine, Sleep Disorder (Disorder), Stress, Migraine in Adults
- Trial name
- MiSleepS (NCT07573488)
- Testing
- Profile-based behavioral sleep and stress management
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Susanne Wegener
Headache, Cognitive Disturbance
Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease
Purpose: There are two goals we have for this prospective single arm study; to see an increase in the amount of gadolinium in 24 hour urine collection following each infusion treatment with Calcium and Zinc DTPA, and to see a…
- Conditions
- Headache, Cognitive Disturbance, Skin Hyperpigmentation, Arthralgia
- Trial name
- NCT02947022
- Testing
- Calcium DTPA, Zinc DTPA
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Tension-type Headache
Does the Addition of Manipulation Provide Added Benefit to Massage Therapy for Tension-type Headache Patients?
Objective. To compare the benefits of spinal manipulation combined with massage therapy versus massage alone in patients with tension-type headache (TTH) on the frequency, intensity and disability caused by headache and on…
- Trial name
- MANIHDI-II (NCT02450955)
- Testing
- Massage, Occiput-Atlas-Axis Technique
- Volunteers
- 105 people
- Sponsor
- University of Valencia
Parturients, Accidental Puncture of Dura During Anaesthesia
Epidural Hydroxyethyl Starch for Post-Dural Puncture Headache in Parturients
The incidence of accidental dural puncture (ADP) among parturients receiving neuraxial labor analgesia has been reported to range from 1% to 1.5%.
- Conditions
- Parturients, Accidental Puncture of Dura During Anaesthesia, Epidural Filling, Hydroxyethyl Starch
- Trial name
- NCT07914790
- Testing
- Epidural hydroxyethyl starch, No epidural hydroxyethyl starch
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Peking University First Hospital
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Post-Dural Puncture Headache
Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
Postdural puncture headache (PDPH) is a common complication after spinal anesthesia. The role of pregabalin and hydrocortisone in the treatment of PDPH is unclear.
- Trial name
- PDPH (NCT03910088)
- Testing
- Pregabalin 100Mg Oral Cap, Hydrocortisone, Acetaminophen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Migraine
Short-Term Effects of Acupuncture on Balance, and Quality of Life in Women With Migraine: A Pilot Study
The goal of this clinical trial is to learn about the short-term effects of acupuncture on migraine-related pain, postural balance, and quality of life in women with migraine.
- Trial name
- SAMBA (NCT07145242)
- Testing
- Acupuncture
- Where
- Lithuania
- Volunteers
- 12 people
- Sponsor
- Laura Zaliene
Migraine Disorders, Virtual Reality
"Potential Effects of Virtual Reality Technology on the Treatment of Migraine-Type Headaches"
The primary objective of this research is to investigate the effects of virtual reality technology on the treatment of migraine-type headaches and assess how this technology may impact the severity, frequency, and duration of…
- Trial name
- NCT06061588
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Post-Concussion Syndrome, Post-Traumatic Headache
Acceptance and Commitment Therapy-based Rehabilitation of Post-concussion Symptoms
The investigators aim to evaluate effects of an outpatient rehabilitation program based on Acceptance and Commitment Therapy compared to usual care on function in patients with post-concussion syndrome (PCS) and post-traumatic…
- Trial name
- NCT04614922
- Testing
- Acceptance and Commitment Therapy
- Where
- Norway
- Volunteers
- 48 people
- Sponsor
- St. Olavs Hospital
Migraine, Medication Adherence
Identifying Factors Underlying the Discontinuation of Triptans
The objective of this study is to identify reasons migraine patients stop using triptan medications for abortive headache treatment.
- Trial name
- NCT00890357
- Where
- 3 sites in United States
- Volunteers
- 292 people
- Sponsor
- Mayo Clinic
Migraine Disorders, Chronic Migraine
HD-EEG Connectivity Changes in Migraine Patients Undergoing Treatment With Anti-CGRP mAbs
Migraine is a leading cause of disability with an estimated prevalence of 12% in Europe. The headache field witnessed a breakthrough since the introduction of specific preventive therapies which proved effective and well…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- NCT06155123
- Testing
- Monoclonal antibody targeting the CGRP pathway (ligand or receptor) (mAbs)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cluster Headache, Episodic
Exploration of Cluster Headache in a PET-MRI Study
Observational study in PET-MRI using the 5-HT1A agonist PET radiotracer [18F]F13640.
- Trial name
- F13640-AVF (NCT05084469)
- Testing
- PET-MRI in pain-free remission period
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Migraine, Head Pain
Anti-CGRP Monoclonal Antibody Response After Switching (AMARAS)
Monoclonal antibodies targeting calcitonin gene-related peptide (mAb-CGRP) have shown efficacy and effectiveness in the treatment of episodic and chronic migraine, however, not all patients respond to them.
- Trial name
- AMARAS (NCT05785988)
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Post Dural Puncture Headache
Caffeine Versus Placebo for Spinal Headaches
Caffeine will be studied against placebo in patients with positional headache after a lumbar puncture (aka "spinal headache").
- Trial name
- NCT00809627
- Testing
- Caffeine, saline
- Where
- United States
- Sponsor
- United States Naval Medical Center, Portsmouth
Migraine, Episodic Migraine
A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine
The purpose of this study is to assess whether galcanezumab is superior to rimegepant in the prevention of migraine in participants with episodic migraine. The study duration will be approximately 6 months.
- Trial name
- CHALLENGE-MIG (NCT05127486)
- Testing
- Galcanezumab, Rimegepant
- Where
- 77 sites in United States
- Volunteers
- 580 people
- Sponsor
- Eli Lilly and Company
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