Clinical trials: Headache Disorder
Headache Disorders, Post-Concussion Syndrome
Can Targeted Education Impact the Current Standard of Care in Patients With Mild Traumatic Brain Injury?
The study will ask the question as to whether or not it is possible to deliver education material to patients with a mild traumatic brain injury in a consistent matter.
- Conditions
- Headache Disorders, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT03391583
- Testing
- Education
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
Post-Traumatic Headache
Hypersensitivity to PACAP-38 in Post-Traumatic Headache
The aim is to investigate whether signaling molecule PACAP-38 induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
- Trial name
- NCT05378061
- Testing
- Pituitary adenylate cyclase activating polypeptide-38
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Chronic Cluster Headache
Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache
Cluster headache is a primary headache that chiefly affects young men, and is less common than migraine. This disease can have devastating consequences due to the pain intensity (it is also called "suicide headache"), to the side…
- Trial name
- ANODECCH (NCT02462395)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- University of Liege
Migraine
Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab
Migraine is a very common, neurological disorder, characterized by recurrent episodes of headache, potential progression to more frequent and severe attack patterns, and associated symptoms.
- Trial name
- COMIG (NCT04114630)
- Testing
- erenumab 70mg/mL
- Where
- 27 sites in Spain
- Sponsor
- Novartis Pharmaceuticals
Headache Disorders, Primary
The Effect of Aerobic Exercise Training for Migraine Prevention.
This study has been designed in order to know the effect of 12 weeks of aerobic exercise training for migraine prevention. We hypothesized that the exercise training could reduce the number of days with migraine and the number of…
- Trial name
- NCT01972607
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Pregnancy, Migraine
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women.
- Conditions
- Pregnancy, Migraine, Headache, Postpartum
- Trial name
- NCT06788977
- Testing
- external Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Cefaly Technology
Migraine Disorders, Migraine
Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as Trexima, In The Acute Treatment Of Multiple Migraine Attacks
The purpose of this study is to determine the consistency of response for Treximet (sumatriptan/naproxen sodium), formerly known as Trexima, when treating four acute migraine attacks at the mild pain phase and within 1 hour of…
- Trial name
- NCT00240630
- Testing
- sumatriptan succinate/naproxen sodium
- Where
- 50 sites in United States
- Volunteers
- 646 people
- Sponsor
- GlaxoSmithKline
Tension-Type Headache
Mulligan Mobilizations Versus Active Release Technique in Tension-type Headache.
Tension-type headaches, characterized by a dull, aching head pain, are one of the most prevalent forms of headache disorders worldwide.
- Trial name
- NCT06452628
- Testing
- Mulligan mobilizations, Active Release Technique, Mulligan mobilizations with active release technique
- Where
- Pakistan
- Volunteers
- 33 people
- Sponsor
- Riphah International University
Temporomandibular Disorders, Headache
Efficacy of Manuel Therapy and BETY in Patients With Temporomandibular Dysfunction Related Headache
The aim of the study is to investigate the effects of Manual Therapy and the Cognitive Exercise Therapy Approach treatment in patients with TMD-related headaches.
- Trial name
- NCT05927545
- Testing
- Patient education and preventive exercise, Patient education, preventive exercise combined with Manual Therapy protocol, Patient education, preventive exercise combined with BETY approach
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hasan Kalyoncu University
Migraine Without Aura
Efficacy Study of Acupuncture in the Prevention of Migraine Without Aura
Acupuncture is commonly used for the prevention of migraine, while the evidence for its efficacy is still uncertain. Current studies have not been able to determine whether the efficacy of acupuncture is due to the actual…
- Trial name
- NCT02765581
- Testing
- Verum acupuncture, Usual care
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Wei Wang
Migraine
A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks
Several observational studies have shown improvement in episodic migraine with the use of greater occipital nerve block as an acute therapy, and a recent placebo controlled trial did not show a decrease in frequency of episodic…
- Trial name
- NCT03159000
- Testing
- Saline, lidocaine/bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Episodic Migraine
Study of Sustained Benefit of AMG334 in Adult Episodic Migraine Patients
The purpose of this study is to compare the sustained long-term benefit between two treatment paradigms of migraine prophylactic agents (erenumab versus a control arm of oral prophylactics) in episodic migraine patients who have…
- Trial name
- NCT03927144
- Testing
- AMG334, Oral Prophylactic
- Where
- 112 sites in United States, Argentina and 16 more
- Volunteers
- 621 people
- Sponsor
- Amgen
Migraine
Tampa Kinesiophobia Scale Modified for Headache
Tampa Kinesiophobia Scale is a scale that has been validated and reliable in individuals with low back pain in the Turkish population and evaluates fear of movement due to the risk of triggering pain.
- Trial name
- Kinesiophobia (NCT06857357)
- Testing
- Questionnaires
- Where
- 14 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 329 people
- Sponsor
- Bozok University
Migraine
Comparing Efficacy and Safety of 2 Dose Regimens of Subcutaneous Administration of TEV-48125 Versus Placebo for the Preventive Treatment of Chronic Migraine
The study is being conducted to evaluate two doses of TEV-48125 in adult patients with chronic migraine
- Trial name
- NCT02621931
- Testing
- Fremanezumab
- Where
- 273 sites in United States, Canada and 7 more
- Volunteers
- 1,130 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine
Cabergoline for Episodic Migraine
The goal of this randomized, placebo-controlled, double-blind clinical trial is to evaluate the efficacy, safety, and tolerability of cabergoline for the prevention of episodic migraine in adults with 4-14 monthly migraine days…
- Trial name
- PROTECT (NCT07072910)
- Testing
- Cabergoline 0.5 MG, Cabergoline 1 MG
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Migraine
Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)
The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain.
- Trial name
- NCT00521196
- Testing
- DC Stimulator (Transcranial Direct Current Stimulator)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cervicogenic Headache
Efficacy of Ultrasound-Guided Multifidus Cervicis Plan Block Vs Greater Occipital Nerve Block for Cervicogenic Headache
Background: Cervicogenic headache (CH) described as a chronic hemi-cranial pain resulted from a disorder of the cervical spine and its anatomic structures innervated by the C1, C2, and C3 cervical spinal nerves.
- Trial name
- UBLOC (NCT04454541)
- Testing
- Ultrasound-guided nerve block for headache management
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Abha International Private Hospital
Migraine, Headache
Registry for Migraine - Structural and Functional MRI Before and After Erenumab Treatment
This study aims to investigate structural and functional cerebral changes using magnetic resonance imaging before and after treatment with erenumab in patients with migraine.
- Trial name
- REFORM (NCT04674020)
- Testing
- Erenumab
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Danish Headache Center
Post-Dural Puncture Headache, Chronic Headache
Long-term Complications of Unintentional Dural Puncture During Labour Epidurals and Epidural Blood Patch.
The investigators plan to evaluate long-term consequences of unintentional dural puncture in women who had this complication during labor epidural insertion at Mount Sinai Hospital.
- Trial name
- NCT04696627
- Testing
- Questionnaire
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Post-dural Puncture Headache, Post-dural Puncture Backache
Long-term Effects of Accidental Dural Puncture in Patients Having Had an Epidural Blood Patch (LEAP)
Accidental dural puncture (ADP) during placement of an epidural catheter for anesthesia and analgesia is a well known complication. Previous studies have found audiometric deterioration following ADP.
- Trial name
- LEAP (NCT02149680)
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
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