Clinical trials: Headache Disorder
Episodic Migraine Headache
A Multicenter Assessment of LBR-101 in High Frequency Episodic Migraine
The purpose of this study is to determine whether monthly subcutaneous administration of LBR-101 (fremanezumab) is safe and provides migraine prevention in subjects with high frequency episodic migraine.
- Trial name
- NCT02025556
- Testing
- LBR-101 High Dose, LBR-101 Low Dose
- Where
- 63 sites in United States
- Volunteers
- 297 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Headaches
Set Point Acupuncture for Migraines Using a Digital Assistant
The object of this research study is to test a standardized set of acupuncture points on migraine patients to reduce frequency and intensity of headaches.
- Trial name
- SPAMDA (NCT00714727)
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Memorial Medical Center
Headache, Migraine
Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.
- Trial name
- NCT01750723
- Testing
- Acetazolamide
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Impact of Combined Oral Contraceptive Pills on Migraine
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.
- Trial name
- NCT06509503
- Testing
- Combined oral contraceptive, Vaginal Ring
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Kafrelsheikh University
Migraine Headache
Greater Occipital Nerve Block for Migraine Prophylaxis
Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized…
- Trial name
- NCT00915473
- Testing
- bupivicaine, normal saline, methylprednisolone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Pediatric Migraine, Migraine Disorders, Brain
Comorbidity-Based Propranolol Use in Pediatric Migraine
This observational retrospective cohort study aims to identify clinical and biochemical predictors of response to propranolol prophylaxis in pediatric migraine.
- Conditions
- Pediatric Migraine, Migraine Disorders, Brain, Vitamin D Deficiency
- Trial name
- NCT07103031
- Testing
- Behavioral therapy, Propranolol
- Where
- Turkey (Türkiye)
- Volunteers
- 488 people
- Sponsor
- Kayseri University
Acute Migraine
Safety and Efficacy Trial of BHV3000 (Rimegepant) 75 mg for the Acute Treatment of Migraine
This trial is to determine whether BHV3000 (rimegepant) 75mg is safe and effictive as a treatment for acute migraine in Chinese and Korean patients
- Trial name
- NCT04574362
- Testing
- Rimegepant
- Where
- 90 sites in China, South Korea
- Volunteers
- 1,648 people
- Sponsor
- Pfizer
Migraine
Phase I, Double-Blind,Placebo, MAD Study to Evaluate the Safety, Tolerability, PK, and PD of AMG 333 in Healthy Subjects and Migraine Subjects
The primary purpose of this study is to evaluate the safety and tolerability of multiple oral doses of AMG 333 for 14 days in healthy subjects and migraine subjects.
- Trial name
- NCT02132429
- Testing
- AMG 333
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Amgen
Headache, Stroke
Sphenopalatine Ganglion Block for the Treatment of Post-Stroke Headache
Determine the effects of sphenopalatine ganglion (SPG) block in post-stroke headache.
- Conditions
- Headache, Stroke, Ischemic Stroke
- Trial name
- NCT05365880
- Testing
- Liquid Lidocaine
- Where
- United States
- Sponsor
- University of Utah
Cervicogenic Headache
Ischemic Compression Technique Versus Jones Technique in Cervicogenic Headache Patients
The primary objective of the study is to determine the effects of Jones and Ischemic compression technique on pain, range of motion and disability in patients with cervicogenic headache.
- Trial name
- NCT06875869
- Testing
- Jones technique, Ischemic compression therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Emergencies
Brain Perfusion Assessment in the Acute Phase of Migraine Aura
The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.
- Trial name
- PERCAM (NCT03821584)
- Testing
- the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Primary Headache Disorder
Primary Headaches and Irritable Bowel Syndrome.
To assess the relationship between primary headaches and irritable bowel syndrome
- Trial name
- NCT05057533
- Testing
- a questionnaire based on Rome IV Diagnostic criteria of IBS
- Where
- Egypt
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tension-type Headache
Assessing the Effectiveness of Two Treatment Strategies for Tension-type Headache
The primary aim of the pilot data proposal is to compare usual care (medications) versus multi-disciplinary treatment in temporomandibular disorder (TMD) patients.
- Trial name
- NCT01347684
- Testing
- Behavioral therapy, splint therapy and physical therapy, Standard care using current drugs
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Migraine
A Controlled Trial to Investigate the Efficacy and Safety of Frovatriptan to Prevent Menstrual Migraine
Although the predictability of an MRM headache attack lends itself to preventative treatment, there are currently no drugs specifically indicated for the prevention of MM.
- Trial name
- NCT00475514
- Testing
- Frovatriptan 2.5mg QD, Frovatriptan 2.5 mg BID
- Volunteers
- 500 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Migraine Headache
Efficacy, Tolerability, and Safety Study of DFN-15
Efficacy, Tolerability, and Safety of DFN-15 in episodic migraine with or without aura, being conducted at multiple centers in the United States.
- Trial name
- NCT03006276
- Testing
- DFN-15 Active
- Where
- 45 sites in United States
- Volunteers
- 622 people
- Sponsor
- BioDelivery Sciences International
Migraine Disorders
Efficacy of Proprioceptive Neuromuscular Facilitation in Pain Relief
The purpose of this study is to determine whether the contract-relax technique of proprioceptive neuromuscular facilitation, and the static stretching exercise are effective in reducing the frequency, intensity and duration of…
- Trial name
- PNF (NCT02549885)
- Testing
- PNF contract-relax, Static stretching
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Cervicogenic Headache, Sleep Disturbance
Effect of Isometric Neck Exercises on Cervicogenic Headache Symptoms, Cortisol and BDNF Levels Among Smart Phone Users
Cervicogenic headache (CGH) is a secondary headache type caused due to refereed pain arising from the cervical spine in the forehead, sometimes in temporal region.
- Conditions
- Cervicogenic Headache, Sleep Disturbance, Stress
- Trial name
- NCT07354776
- Testing
- Isometric Neck Exercise Program, Usual Care
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Post-Dural Puncture Headache
Comparing the Effects of Ondansetron Versus Dexamethasone on the Incidence of Post-dural Puncture Headache (PDPH) , Nausea and Vomiting After Spinal Anaesthesia of Parturients Undergoing Caesarean Section
Comparing dexamethasone and ondanestrone injection in ncidence of postdural puncture headache and post-partum nausea and vomiting
- Trial name
- NCT05202574
- Testing
- Intravenous drug
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Migraine
The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients
The aim of this study is to determine the effects of omega 3 fatty acid, curcumin and their combination or placebo for 2 months on the gene expression of COX-2, iNOS, TNF-α, IL-1β, IL-6, VCAM-1 and ICAM-1 in the peripheral blood…
- Trial name
- NCT02532023
- Testing
- omega 3 fatty acid, curcumin
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Cluster Headache
A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache
Topiramate is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of patients with seizures. The trade name for this drug is Topamax®.
- Trial name
- NCT00203190
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
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