Clinical trials: Headache Disorder
Migraine
Efficacy and Safety Trial of Rimegepant for Migraine Prevention in Adults
The purpose of this is study is to compare the efficacy of BHV-3000 (rimegepant) to placebo as a preventive treatment for migraine, as measured by the reduction in the number of migraine days per month.
- Trial name
- NCT03732638
- Testing
- Rimegepant
- Where
- 93 sites in United States
- Volunteers
- 1,590 people
- Sponsor
- Pfizer
Migraine Disorders
Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine
This randomized controlled trial evaluated whether adding melatonin to propranolol provided better prevention of migraine in children than propranolol alone.
- Trial name
- NCT07743255
- Testing
- Melatonin, Propranolol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Headache Disorders
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) on Headache, Cranial Hemodynamic and Autonomic Symptoms in Healthy Volunteers
Vasoactive intestinal peptide (VIP) is a peptide of 28 amino acid residues that belongs to the glucagon/secretin superfamily of peptides.
- Trial name
- NCT03989817
- Testing
- Vasoactive Intestinal Peptide (VIP) and Saline
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Enfacement Illusion and Chronic Migraine Pain
The concept of body image can be described as "the intentional content of consciousness comprising perceptions, attitudes and beliefs relating to one's body".
- Trial name
- NCT04904458
- Testing
- Experimental group ("enfacement illusion"), Control Group (Pleasant virtual environment exposure)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine
Phase II Trial of PRT-064040 Nasal Spray for the Treatment of Migraine in Adults
The purpose of this study is to learn about the efficacy and safety of PRT-064040 Nasal Spray versus placebo in the acute treatment of moderate or severe migraine.
- Trial name
- NCT07304518
- Testing
- PRT-064040 nasal spray
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Sichuan Purity Pharmaceutical Technology Co., Ltd.
Post-Dural Puncture Headache
The Occurrence of Post Dural Puncture Headache After Epidural Blood Patch
Spinal anesthesia is commonly used for cesarean section.However, the procedure is still have some adverse events such as high spinal block, nerve injuries or postdural puncture headache (PDPH).This is a potential complication of…
- Trial name
- NCT03080610
- Where
- 2 sites in Thailand
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Migraine
Abortive Treatment of Migraine With the Cefaly® Abortive Program Device
The purpose of this study is to investigate the efficacy of the Cefaly® Abortive Program device used at home for 2 hours to treat a migraine attack.
- Trial name
- NCT03217968
- Testing
- Cefaly® Abortive Program device
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Cefaly Technology
Migraine, Sleep Disturbance
The Effect of Bright Light Therapy on Migraine With Sleep Disturbance
Migraine is a common disabling disorder and its substantial burden is associated with considerable negative impact on quality of life.
- Trial name
- NCT04890691
- Testing
- Feel Bright Light
- Volunteers
- 60 people
- Sponsor
- Hungkuang University
Chronic Cluster Headache, Primary Headache Disorder
Treatment of Chronic Cluster Headache with TENS and ONS
The study is an investigator-initiated, prospective, randomized, placebo-controlled, double blind clinical trial that aims to investigate the effect of transcutaneous electrical nerve stimulation (TENS) and occipital nerve…
- Conditions
- Chronic Cluster Headache, Primary Headache Disorder, Headache, Cluster Headache
- Trial name
- HortONS (NCT05023460)
- Testing
- Paresthesia-free (burst) ONS
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- University of Aarhus
Headache Disorders, Influenza -Like Illness
InfluenCEF Study: Study on the Headache Associated With Influenza Infection
The goal of this observational analytic study with a cohort desing is to evaluate the epidemiology, risk factors and clinical phenotype of headache during Influenza infection.
- Conditions
- Headache Disorders, Influenza -Like Illness, Head Pain, Migraine
- Trial name
- INFLUENCEF (NCT05704335)
- Testing
- Questionnaire administration
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Labor Pain, Epidural Analgesia
Different Spinal Needles Sizes and Dural Puncture Epidural For Labor Analgesia
The rationale behind the dural puncture epidural (DPE) technique lies in the fact that a dural perforation with a spinal needle purportedly creates a conduit for accelerated translocation of local anesthetics from the epidural to…
- Trial name
- NCT03389945
- Testing
- 25G Dural Puncture Epidural Block, 27G Dural Puncture Epidural Block
- Where
- 2 sites in Chile
- Volunteers
- 140 people
- Sponsor
- University of Chile
COVID-19
The Effects of Long-Term Mask Use in the Pandemic Period
Various restrictions have been made all over the world due to coronavirus pandemics. In addition to situations such as social isolation and hygiene, the use of masks is among these rules.
- Trial name
- NCT05358665
- Testing
- mask use
- Where
- Turkey (Türkiye)
- Volunteers
- 909 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Treatment of Chronic Cluster Headache
The primary objective of the study is to demonstrate the safety and efficacy of SPG stimulation with the ATI Neurostimulation System when used to treat acute cluster attacks in chronic cluster headache patients.
- Trial name
- NCT02168764
- Testing
- ATI Neurostimulation System
- Where
- 24 sites in United States
- Volunteers
- 120 people
- Sponsor
- Autonomic Technologies, Inc.
Fibromyalgia, Migraine
Zonisamide for Fibromyalgia & Migraine
Patients with fibromyalgia \& migraine are randomized to receive zonisamide or placebo.
- Trial name
- NCT00259636
- Testing
- zonisamide
- Where
- United States
- Sponsor
- University of Pittsburgh
Headache, Migraine
Comparison of a Drug and Placebo in the Prevention of Migraine Headaches
The purpose of this study is to determine whether ethosuximide works better than placebo in the prevention of episodic migraine among veterans.
- Trial name
- NCT01122381
- Testing
- ethosuximide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- US Department of Veterans Affairs
Headache, Migraine
Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP
Aims: To investigate the efficacy of laser-acupuncture for the severity of primary headache and comorbidities, and the Lab data examination.
- Trial name
- NCT06584409
- Testing
- Laser Pen, Observation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Migraine-related Headache
The Effect of Wet Cupping Therapy on Headache and Migraine-related Disability
Objective: This study aims to investigate the effects of wet cupping therapy (cupping) applied once to the head and neck region on the severity of headache and disability in patients diagnosed with migraine.
- Trial name
- NCT06568757
- Testing
- Wet Cupping, No intervention
- Volunteers
- 60 people
- Sponsor
- Mersin University
Primary Headache, Migraine in Adolescence
nVNS for the Prevention and Treatment of Primary Headache
This study is a single-center, single-arm study. All subjects will receive the same treatment. Children and adolescents (7-20 years old) with migraine who met the inclusion criteria will be enrolled as subjects in the…
- Conditions
- Primary Headache, Migraine in Adolescence, Migraine in Children, Cluster Headache
- Trial name
- NCT06277063
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Postdural Puncture Headache, Sphenopalatine Ganglion Block
Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714
The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the…
- Trial name
- NCT03966547
- Testing
- Ganglion sphenopalatine block with local anesthetic administered on study GSPB-2018
- Where
- 2 sites in Denmark
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Uterine Fibroids, Osteoporosis
Women's Use of Alternative Medicine: A Multiethnic Study
The purpose of this study is to examine socio-cultural factors of women's use of complementary and alternative medicine (CAM). The effects of socioeconomic status, social networks and acculturation on CAM use will be assessed…
- Conditions
- Uterine Fibroids, Osteoporosis, Urinary Tract Infection, High Blood Pressure
- Trial name
- NCT00067249
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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