Clinical trials: Headache Disorder
Migraine
Telcagepant for Prevention of Menstrually Related Migraine in Female Participants With Episodic Migraine (MK-0974-065)
This is a multicenter study to test the hypothesis that telcagepant is superior to placebo in preventing perimenstrual migraines as measured by mean monthly headaches during the entire treatment period.
- Trial name
- NCT01125774
- Testing
- Telcagepant
- Volunteers
- 4,548 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine, Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain.
- Conditions
- Migraine, Pain, Nausea, Vomiting
- Trial name
- NCT03877718
- Testing
- Arm 1: CL-H1T, Arm 2: CL-H1T, Arm 3: Sumatriptan Succinate 100 mg capsule
- Where
- 3 sites in United States
- Volunteers
- 475 people
- Sponsor
- Charleston Laboratories, Inc
Migraine
The Effect of Sumatriptan and Placebo Injection on Cilostazol Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol).
- Trial name
- NCT03422796
- Testing
- Cilostazol 200mg, SUMAtriptan 6 MG/ML
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Danish Headache Center
Migraine With Aura, Migraine
The Effect of Connective Tissue Massage in Patients With Migraine
The aim of this study was to investigate the effectiveness of connective tissue massage in patients with migraine
- Conditions
- Migraine With Aura, Migraine, Migraine Without Aura, Connective Tissue Diseases
- Trial name
- NCT04171362
- Testing
- Connective Tissue Massage, Education
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Ankara Yildirim Beyazıt University
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Insomnia Chronic, Migraine Disorders
Digital CBTI for Comorbid Insomnia in Chronic Migraine
The overall aims of the study are: Aim 1: Estimate effect sizes: To estimate the effects of dCBT-I on insomnia symptoms compared to a control group (sleep hygiene education) and estimate the relationship between changes in…
- Trial name
- NCT05244889
- Testing
- Digital CBT-I, Sleep Hygiene Education
- Where
- 2 sites in United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Strathclyde
Post-Dural Puncture Headache
RCT of SPG Blocks for Post-dural Headache
The purpose of the study is to assess the effectiveness of the SPG block with lidocaine vs. SPG block with placebo on preventing the need for EBP in women who develop PDPH after accidental dural puncture during placement of LEA…
- Trial name
- NCT03560349
- Testing
- Lidocaine HCl Gel 2%
- Where
- United States
- Sponsor
- University of Utah
Primary Headaches (Includes Migraines, Tension, Cluster Headaches), Hydration
Hydration in Children and Adolescents With Primary Headaches
The aim of this study is to investigate the role of hydration and fluid intake in children and adolescents with primary headaches.
- Conditions
- Primary Headaches (Includes Migraines, Tension, Cluster Headaches), Hydration, Adolescent, Children
- Trial name
- H20KIDS (NCT06816849)
- Testing
- Recommended water intake
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Post-Dural Puncture Headache
Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries
Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%.
- Trial name
- NCT06729047
- Testing
- normal Saline, Neostigmine, Ketorolac
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Assiut University
Migraine Disorders, Headache Disorders
Topical Bimatoprost in the Treatment of Migraine
The study is to assess the effectiveness of topically applied bimatoprost in reducing migraine headache frequency, severity, and duration. It will also assess the effect of topical bimatoprost on quality of life.
- Trial name
- NCT03419715
- Testing
- Bimatoprost Topical Solution, Control
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Manistee Partners
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Headache, Migraine
0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment
Headache is a frequent chief complaint among patients presenting to the Emergency Department (ED), accounting for 2.1 million visits annually in the United States.
- Conditions
- Headache, Migraine, Tension Headache, Occipital Neuralgia
- Trial name
- NCT06937385
- Testing
- 0.5% Bupivacaine HCl, standard IV treatment for headache
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- HCA Florida North Florida Hospital
Migraine
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to <12 years) and adolescents (12 to <18 years) with episodic migraine.
- Trial name
- OASIS(EM) (NCT03836040)
- Testing
- Erenumab Dose 1, Erenumab Dose 2, Erenumab Dose 3
- Where
- 11 sites in United States, Belgium and 2 more
- Volunteers
- 457 people
- Sponsor
- Amgen
Migraine, Migraine in Children
Intravenous Fluids in Pediatric Migraine
The goal of this clinical trial is to compare intravenous (IV) fluids in pediatric patients with migraine. The main questions it aims to answer are: Does a large amount of fluids (bolus) improve pain Does a large amount of fluids…
- Trial name
- NCT06182098
- Testing
- 1/2 maintenance fluids, Ketorolac, Diphenhydramine
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Dayton Children's Hospital
Post Traumatic Headache
Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction
The purpose of this study is to determine whether naratriptan, a medication approved for treatment of migraine, is effective in the treatment of post traumatic headache associated with cognitive dysfunction.
- Trial name
- NCT00487578
- Testing
- naratriptan HCl
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cady, Roger, M.D.
Migraine
Open-trial on the Prevention of Chronic Migraines With the CEFALY Device
The main objective of this study was to assess the safety and efficacy of the Cefaly® e-TNS device as a prophylactic treatment of chronic migraine in adult patients.
- Trial name
- NCT02342743
- Testing
- CEFALY
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Cefaly Technology
Headache, Migraine
Headache Inducing Effect of Levcromakalim in Migraine With Aura Patients
To investigate the role of KATP channels in migraine with aura patients.
- Conditions
- Headache, Migraine, Aura
- Trial name
- NCT04012047
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- Danish Headache Center
Manual Lymphatic Drainage
Manual Lymph Drainage in Individuals With Migraine
In the literature, research into the examination of the effect of MLD on migraine is quite limited. Our study aimed to examine the effectiveness of manual lymph drainage and connective tissue massage treatments on neck pain and…
- Trial name
- NCT05976399
- Testing
- Connective Tissue Massage, Manual Lymph Drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Democracy University
Migraine Without Aura
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COMPETE (NCT05889455)
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine
Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin
The involvement of calcitonin gene-related peptide (CGRP) in the cinnamaldehyde-induced dermal blood flow increase and in the mechanism of action of triptans will be investigated.
- Trial name
- NCT05654298
- Testing
- Sumatriptan, Ubrogepant
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.