Clinical trials: Headache Disorder
Cervicogenic Headache
Effects of Workstation Ergonomics and Physiotherapy in Cervicogenic Headache.
Cervicogenic headache (CgH) is a distinct form of headache and accounts for 17.8% of all headaches and the prevalence rate is between 0.4% and 20%.
- Trial name
- NCT05827185
- Testing
- Ergonomic modifications, Physiotherapy, Ergonomic modifications and Physiotherapy
- Where
- Saudi Arabia
- Volunteers
- 96 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Temporomandibular Disorder, Headache Disorders
Validation of the TMD Pain Screener in a Specialized Headache Center
The purpose of the study is to investigate whether a questionnaire can be used to detect whether patients referred to the Danish Headache Center have a painful temporomandibular disorder (TMD).
- Trial name
- NCT04193111
- Testing
- TMD pain screener
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine, Greater Occipital Nerve Pulsed Radiofrequency, Headache Disorders
Comparing Unilateral and Bilateral Proximal GONPRF in Migraine Treatment
This study is designed to compare the clinical effectiveness of unilateral and bilateral Greater Occipital Nerve Pulsed Radiofrequency (GON-PRF) treatment at the C2 level in patients with migraine.
- Conditions
- Migraine, Greater Occipital Nerve Pulsed Radiofrequency, Headache Disorders, Ultrasound Guided Nerve Block
- Trial name
- (UBGON-PRF) (NCT06894121)
- Testing
- Greater Occipital Nerve Pulsed Radiofrequency (Unilateral), Bilateral GON PRF Treatment:
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine
Non-pharmacological Treatments in Migraine.
Migraine may have an adverse effect on physical, cognitive, and psychosocial functioning. It causes major consequences for the quality of life of the sufferer and a major burden on the health care system.
- Trial name
- NCT05596058
- Testing
- dual task protocol: active exercises with concomitant cognitive training in executive functions, active exercise, cognitive task only
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Trieste
Chronic Cluster Headache
Pathway CH-1 Long-Term Follow-Up
The objective of the study is to demonstrate the long-term safety and performance of the ATI Neurostimulation System when used for stimulation of the sphenopalatine ganglion (SPG) in cluster headache subjects.
- Trial name
- NCT01616511
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 33 people
- Sponsor
- Autonomic Technologies, Inc.
Intracranial Hypotension
The Blood Patch in the Management of Intracranial Hypotension
Intracranial hypotension results from leakage and/or hypotension of cerebrospinal fluid. It can be spontaneous or secondary to a dural puncture complicating perimedullary anesthesia or a lumbar puncture.
- Trial name
- BPIH (NCT06498804)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Migraine With or Without Aura
Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine
The study consists of a screening visit, out-patient treatment of a moderate or severe migraine attack with a single dose of the study medication within 8 weeks, and End-of-Study Visit 2-7 days after dosing.
- Trial name
- ANODYNE-1 (NCT03061734)
- Testing
- Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Allodynic Therapeutics, Inc
Migraine Headaches, Nausea
Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT
Haloperidol is known to be a safe alternative medication to control difficult pain, and has been shown effective when compared to placebo for controlling headaches.
- Conditions
- Migraine Headaches, Nausea, Restlessness
- Trial name
- NCT02098499
- Testing
- Haloperidol, Metoclopramide 10mg, Diphenhydramine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Cervicogenic Headache
Effectiveness of a Novel Device for Cervical Training in Cervicogenic Headache.
The purpose of this study is to evaluate the clinical results in cervical spine range of motion, endurance deep cervical muscles, headache impact and physical activity enjoyment by a training protocol with the new device for…
- Trial name
- NCT05479149
- Testing
- Training protocol with the cervical device for treatment (CDAT)., Conventional training protocol
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Internacional de Catalunya
Covid19
Efficacy of Adaptogens in Patients With Long COVID-19
The aim of this clinical trial of a fixed combination of standardized extracts from Rhodiola rosea roots, Schisandra chinensis berry and Eleutherococcus senticosus root (ADAPT-232) in COVID-19 patients is to demonstrate possible…
- Trial name
- NCT04795557
- Testing
- ADAPT-232 oral solution
- Where
- Georgia
- Volunteers
- 100 people
- Sponsor
- Swedish Herbal Institute AB
Migraine Disorders
Temporal, Environmental, and Genetic Factors Regulating Exercise and Migraine
Chronic pain, of which migraine is among the most common, affects 100 million US adults and costs between $560 to $635 billion dollars annually.
- Trial name
- NCT04553445
- Testing
- Chronotype, Green exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Chronic Daily Headache, Post-Traumatic Headache
Assessment of the Efficacy of the Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Daily Headache in Children and Adolescents.
Primary Objective The primary objective of the study is to assess whether transnasal sphenopalatine ganglion block using the device TX360 reduces intensity and severity of the Post-Traumatic Headache in adolescents.
- Trial name
- SPG (NCT05213065)
- Testing
- Sphenopalatine ganglion block with 0.5% bupivacaine, Sphenopalatine ganglion block with saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Pablo Ingelmo
Migraine Without Aura
Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura
This is a a multi-center, randomized, double-blind, parallel group, and placebo controlled, two-arm study of a single oral dose of NXN-188 for the treatment of acute migraine headache without aura.
- Trial name
- NCT00959751
- Testing
- NXN-188
- Where
- 4 sites in United States
- Volunteers
- 195 people
- Sponsor
- NeurAxon Inc.
Migraine Disorders
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
A 6-month, observational, post authorization safety study for the collection and evaluation of additional safety data on topiramate as a prophylactic treatment for migraines in adult patients.
- Trial name
- NCT00297336
- Testing
- Topiramate
- Volunteers
- 80 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Migraine in Children, Posttraumatic Headache
A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine
Headaches in children are very common and are a source of significant distress for the patient and their family. Migraines are the most common headache disorder in children and are associated with episodic pain and other symptoms…
- Trial name
- NCT03806595
- Testing
- Lidocaine 2% Injectable Solution, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
High Blood Pressure, Migraine Headaches
Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting Conditions
The purpose of this study is to demonstrate the relative bioavailability of Nadolol (1 x 80 mg) tablets under fasting conditions.
- Conditions
- High Blood Pressure, Migraine Headaches, Chest Pain
- Trial name
- NCT00960245
- Testing
- Nadolol (1 x 80 mg) Tablets (Invamed, Inc), Corgard (1 x 80 mg) Tablets (Bristol Laboratories)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sandoz
Migraine
Evaluation of a New Treatment for Migraine Attacks
The purpose of this study is to evaluate the efficacy of a novel therapy for treatment of migraine, pain reduction and relief of associated symptoms during ongoing migraine attacks, and presence of a preventive effect post…
- Trial name
- NCT01880671
- Testing
- Inactive Migraine Medical Device, Migraine Medical Device
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska University Hospital
Migraine Disorders
Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old
A Phase 4 study to evaluate Qudexy XR for the prevention of migraine in children 6 to 11 years of age.
- Trial name
- NCT04748601
- Testing
- Qudexy XR
- Where
- 15 sites in United States
- Volunteers
- 132 people
- Sponsor
- Upsher-Smith Laboratories
Migraine
Efficacy of AJOVY (Fremanezumab-vfrm) on Interictal Migraine Related Burden
This study is being conducted to evaluate the efficacy and safety of AJOVY (fremanezumab-vfrm) on interictal migraine related burden in adults.
- Trial name
- NCT04461795
- Testing
- Fremanezumab-Vfrm 225 MG/1.5 ML Subcutaneous Solution [AJOVY]
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- David True
Migraine, Ultrasound
Therapeutic Ultrasound in the Treatment of Migraine
Headache affects the daily quality of life of patients. It has been reported that headaches may be associated with neck muscles, neck movements and trigger points in the neck Drug and non-drug treatments can be used today in the…
- Trial name
- NCT03459495
- Testing
- therapeutic ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
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