Clinical trials: Headache Disorder
Epidural; Anesthesia, Headache, Analgesia
Comparison of Infiltration of 2% Lidocaine With and Without Needle as Analgesia in Epidural Needle Insertion
One way to reduce pain during epidural needle insertion is infiltration of lidocaine using a needle. However, infiltration of lidocaine using the needle alone is a painful process.
- Trial name
- NCT05326867
- Testing
- Infiltration of 2% Lidocaine with Needle, Infiltration of 2% Lidocaine without Needle
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Indonesia
Chronic, Medically Refractory Headache
Bion Occipital Nerve Stimulation (ONS) Compassionate Use Study
The purpose of this compassionate use study is to provide clinical and technical support of the Bion® microstimulator system to the subjects who have decided to keep the system for relief of headache symptoms that have not…
- Trial name
- NCT01050959
- Testing
- bion
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Boston Scientific Corporation
Bipolar Disorder, Major Depression
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances.
- Conditions
- Bipolar Disorder, Major Depression, Migraine
- Trial name
- NCT05669703
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Post-Dural Puncture Headache
Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients
The purpose of this trial is to study the efficacy and efficiency of sphenopalatine ganglion block for management of post dural puncture headache in obstetric patients
- Trial name
- NCT04793490
- Testing
- Sphenopalatine ganglion block, paracetamol
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Chronic Headache
Combined Biofeedback With Virtual Reality in the Treatment of Pediatric Headache
The objective of the study is to examine the effect of combined treatments (biofeedback with virtual reality) for pediatric chronic headache.
- Trial name
- VR (NCT00897780)
- Testing
- Biofeedback with virtual reality
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Migraine Headache
TelemEdiciNe-bAsed Cognitive TherapY for Migraines
The goal of this pilot study is to evaluate a bundle of implementation strategies at three Veteran Affairs Medical Centers (VAMCs) to facilitate the referral and adoption of a telehealth based, cognitive behavioral therapy…
- Trial name
- TENACITY (NCT04613362)
- Testing
- TENACITY Telehealth Cognitive Behavioral Therapy for Migraine, Behavioral Usual Care
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Migraine
PSG and Neuroendocrine Hormones in Subjective Cognitive Impaired Patients With Transformed Migraine
Transformed migraine is the most common and challenging subtype of chronic daily headache disorders35. Patients with transformed migraine often report an evolutionary process that occurs over months or years in which headaches…
- Trial name
- NCT04413110
- Testing
- Polysomnography
- Where
- Egypt
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Chronic Pain, Trigeminal Neuralgia
Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study
There is a significant debate whether local infiltration techniques may be a method to treat complicated chronic pain syndromes, e.g. refractory headache.
- Conditions
- Chronic Pain, Trigeminal Neuralgia, Cluster Headache, Post-Zoster Neuralgia
- Trial name
- RetroBlock (NCT03066037)
- Testing
- regional-anaesthesiological infiltration
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Charite University, Berlin, Germany
Migraine, With or Without Aura
Safety and Efficacy in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant) versus placebo in subjects with Acute Migraines
- Trial name
- NCT03237845
- Testing
- Rimegepant
- Where
- 50 sites in United States
- Volunteers
- 1,499 people
- Sponsor
- Pfizer
Chronic Migraine, Medication Overuse Headache
Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse Headache
The purpose of the study is to evaluate the efficacy of the transcranial direct current stimulation of the primary motor cortex (M1) in patients affected by refractory chronic migraine (coded as 1.5.1 in the international…
- Trial name
- NCT01752439
- Testing
- Anodal transcranial direct current stimulation
- Volunteers
- 30 people
- Sponsor
- Dr Armando Perrotta, MD, PhD
Migraine
Normobaric Oxygen (NBO) Therapy in Acute Migraine
This is a pilot study investigating the therapeutic potential of breathing 100% oxygen in acute migraine headache.
- Trial name
- NCT01542307
- Testing
- Oxygen, Room air
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Migraine
Effectiveness and Neural Mechanism of Naoan Dripping Pills for Migraine
This is a randomized, double-blind, placebo-controlled clinical trial. Its main purpose is to investigate the effects and neural mechanism of Naoan dripping pills on migraine patients by utilizing fMRI and DTI method, as well as…
- Trial name
- ENMNM (NCT03175900)
- Testing
- Naoan dripping pills
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Migraine
Evaluation of the Performance of the Doraldo-Castelletti Scale in Supporting the Neurologist's Decision to Refer Migraine Patients to Physiotherapy
Migraine is the leading cause of disability worldwide among people aged 15 to 49. Although therapies targeting the CGRP pathway have improved the management of the condition, there are large groups of patients who do not respond…
- Trial name
- MIGSKA (NCT07626307)
- Testing
- Doraldo-Castelletti scale
- Where
- Italy
- Volunteers
- 439 people
- Sponsor
- Istituto Auxologico Italiano
Chronic Migraine, Medication Overuse Headache
Anodal tDCS in Chronic Migraine With Medication Overuse
Non-invasive neuromodulation has been applied in several forms of primary headaches, and its usefulness has been suggested for both episodic and chronic migraine (CM).
- Trial name
- NCT04336267
- Testing
- Transcranial direct current stimulation (tDCS) group
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Tension-Type Headache
Auriculotherapy in Tension-type Headache Due to Temporomandibular Dysfunction
Objectives: Verify the effect of auriculotherapy in patients with tension-type headache resulting from temporomandibular dysfunction.
- Trial name
- NCT02309775
- Testing
- Auriculotherapy
- Volunteers
- 38 people
- Sponsor
- Federal University of Minas Gerais
Chronic Migraine
Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
Chronic migraine is a disabling type of migraine and is often resistant to treatment. Non-pharmacological interventions have been investigated as potential treatment although, unfortunately, the literature on their efficacy is…
- Trial name
- NCT03404336
- Testing
- Well-Being Therapy, Control condition
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Florence
Headache, Migraine, Quality of Life
Effects of Aromatherapy on the Headache and Service Quality Among Nurses Working in Critical Care Nurses Units.
Background: Our pilot study showed that the prevalence of headaches is 43.5% among nurses working in critical care units in a medical center in Taiwan.
- Trial name
- NCT03867864
- Testing
- Necklace with essential oil for the first 4 weeks, Necklace without essential oil for the first 4 weeks, Washout
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
PFO - Patent Foramen Ovale, Migraine
A Comparison of Biodegradable and Metal Occluders in Patients With PFO and Migraine
Migraine is one of the most common chronic neurological disorders, posing a significant global public health concern. Patent Foramen Ovale (PFO) is the most common congenital heart anomaly in adults.
- Conditions
- PFO - Patent Foramen Ovale, Migraine, Migraine Headache, Migraine Headache, With or Without Aura
- Trial name
- BioMetal (NCT06203873)
- Testing
- Biodegradable occluder, Metal occluder
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Migraine, Headache
Non-drug Interventions for Migraines
This proposal describes a randomized controlled pilot trial investigating feasibility, safety, and migraine frequency in patients with migraines who undergo an 8 week mindfulness based stress reduction (MBSR) program compared to…
- Trial name
- NCT01545466
- Testing
- Mindfulness Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Migraine Disorders, Headache Disorders
Idebenone for the Preventive Treatment of Migraine
Idebenone improves energy metabolism similarly to Coenzyme Q10, which is effective in migraine prophylaxis. The investigators compare idebenone (90 mg/day, 270 mg/day) and placebo in 180 migraine patients in a double-blind…
- Trial name
- NCT04151472
- Testing
- 90mg Idebenone, 270mg Idebenone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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