Clinical trials: Headache Disorder
Migraine
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine
This is a double-blind, randomized, multicenter, outpatient evaluation of the safety and efficacy of elismetrep as compared to placebo in the acute treatment of migraine.
- Trial name
- NCT06848075
- Testing
- Elismetrep (K-304) 2 mg, Elismetrep (K-304) 5 mg, Elismetrep (K-304) 10 mg
- Where
- 66 sites in United States
- Volunteers
- 431 people
- Sponsor
- TriGemX Bio, Inc.
Migraine
Assessment of Safety and Efficacy of Nerivio for the Migraine Prevention
Migraine is a common neurologic with attacks of headache and associated symptoms such as nausea, vomiting, phono and photophobia. Migraine can lead to substantial functional impairment.
- Trial name
- NCT04828707
- Testing
- Nerivio active device
- Where
- 16 sites in United States
- Volunteers
- 335 people
- Sponsor
- Theranica
Migraine Headache
Effectiveness and Acceptability of MINDFULNESS by Smartphone, for Patients with Chronic Migraine and Medication Overuse
Chronic Migraine is a disabling condition that affects the 2% of migraine population. It is often associated with medication overuse that makes this condition very difficult to treat.
- Trial name
- ChroMig-Smart (NCT04389372)
- Testing
- Mindfulness
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Major Depression, Chronic Primary Headache
An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache
Background: Although major depression and chronic headache are strongly associated, there is insufficient evidence on the use of antidepressants for this specific comorbidity.
- Trial name
- NCT00531895
- Testing
- duloxetine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Kraepelin Psiquiatria Clinica
Brain Concussion, Mild Traumatic Brain Injury
Concussion Recovery and Support Program
Pilot randomized controlled trial (RCT) comparing a novel intervention Concussion Recovery and Support Program (CRISP) for adolescents and young adults (AYA) 18-29 yo with concussion/ mild TBI.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache
- Trial name
- CRISP (NCT07097792)
- Testing
- CRISP (Concussion Recovery and Support Program)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Hip Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Hip osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Hip Osteoarthritis
- Trial name
- NCT07347041
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Migraine Headaches
The Efficacy of Neurofeedback Mindfulness in Migraine Management
This longitudinal randomized controlled trial explored how long-term practice of neurofeedback mindfulness would be helpful for migraine management when compare dot a similar controlled intervention.
- Trial name
- NCT06342232
- Testing
- Neurofeedback mindfulness, Simple attention controlled task
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- University of Saskatchewan
Cervicogenic Headache
Effects of Jones Technique and Cross Friction Massage on Cervicogenic Headache.
Cervicogenic headache is a very incessant issue that is often faced by the general population. Cervicogenic headache is a significant issue in patients with upper cervical dysfunction.
- Trial name
- NCT06452641
- Testing
- Jones technique, Cross-friction massage
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Migraine, Traumatic Brain Injury
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI).
- Conditions
- Migraine, Traumatic Brain Injury, Anomalous Health Incidents
- Trial name
- NCT07267819
- Testing
- Xeomin (incobotulinumtoxinA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
Migraine, Prophylaxis
Atogepant in Real Life in Italy (GIANT)
Atogepant is an oral, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist that has been approved for the preventive treatment of episodic and chronic migraine (>= 4 monthly migraine days) with or without…
- Trial name
- GIANT (NCT06136442)
- Testing
- Atogepant
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele Roma
Migraine
Nerivio Efficacy Under High-Frequency Use
This is a Post-marketing study investigating the impact of frequant usage with Nerivio on the safety profile of Remote Electrical Neuromodulation (REN) for the treatment of migraine.
- Trial name
- NCT07336056
- Testing
- Nerivio (REN device)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Theranica
Migraine With Aura
Induction of Migraine Aura With Sildenafil
In a double blind placebo-controlled cross-over study the effect of Sildenafil on aura and migraine headache induction is tested in patient with migraine with aura.
- Trial name
- NCT02795351
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Herlev Hospital
Migraine Disorders
Efficacy, Safety, Tolerability and Pharmacokinetics of BIBN 4096 BS Versus Placebo in the Treatment of a Single Attack of Acute Migraine Headache
Efficacy, Safety, Tolerability and Pharmacokinetics of BIBN 4096 BS in patients with a single acute migraine attack with or without aura
- Trial name
- NCT02198339
- Testing
- BIBN 4096 BS
- Volunteers
- 126 people
- Sponsor
- Boehringer Ingelheim
Post-Dural Puncture Headache
EPiMAP Obstetrics: European Practices in the Management of Accidental Dural Puncture in Obstetrics
The aims of EPiMAP Obstetrics are: to identify risk factors for failure of epidural blood patch in the obstetric population for management of post dural puncture headache.
- Trial name
- EPiMAP (NCT02362828)
- Where
- Sweden
- Volunteers
- 1,110 people
- Sponsor
- European Society of Anaesthesiology
Migraine Disorders, Chronic Migraine
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
Primary working hypothesis is that NON-responders to mAbs bear a dysfunction of the endocannabidiome system (eCBome), as suggested by pre-clinical and clinical data by our group.
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP2 (NCT06562400)
- Testing
- Palmitoyl ethanolamide, Ketogenic diet
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine, Migraine Disorders
Real-world Effectiveness and Tolerability of Triptans-Ditans-Gepants (TRIDIGEP)
Migraine is the third most prevalent disease and the leading reason of years lived with disability in the most productive years of the life. Migraine associated disability can be alleviated by acute and preventive treatment.
- Conditions
- Migraine, Migraine Disorders, Migraine With Aura, Headache Disorders
- Trial name
- TRIDIGEP (NCT06267664)
- Testing
- Patients with migraine treated with triptans, Lasmiditan or Gepants
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Migraine
Nasal Cavity Cooling for the Symptomatic Relief of Migraine Headache - a Pilot Study
The aim of the study is to evaluate the effect of self-administered intranasal cooling for the symptomatic relief of migraine headache and associated symptoms in an "at home setting".
- Trial name
- NCT04660864
- Testing
- Nasal cavity cooling device.
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lund University
Migraine
Botox Vs Spinal Cord Stimulation in the Treatment of Refractory Migraine Clinical Trial
The clinical trial is focused on the treatment of selected patients with a migraine after implantation of spinal cord stimulator (SCS) based on previous neurological examination.
- Trial name
- BTX/SCS/TMig (NCT05382832)
- Testing
- SCS
- Volunteers
- 50 people
- Sponsor
- EPC Education s.r.o.
Headache Migraine
Investigating the Impact of Acupuncture on the Quality of Life of Primitive Headaches Patients
Primary headache is one of the most common neurological diseases in modern society, which seriously affects the patient's quality of life.
- Trial name
- NCT06398353
- Testing
- Real acupuncture
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Endometriosis, Migraine
Identification of Endometriosis and Migraine Criteria in Women With the Comorbidity of Both Conditions in Comparison With Women Who Only Suffer From Endometriosis - A Pilot Study
Patients with both, migraine and endometriosis, present the case-group, while women with endometriosis without migraine serve as controls.
- Trial name
- NCT04816357
- Testing
- Questionaire
- Where
- Switzerland
- Volunteers
- 344 people
- Sponsor
- Zurich University of Applied Sciences
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