Clinical trials: Headache Disorder
COVID-19, Headache Disorders
Impact of COVID-19 Pandemic on Headache Evaluations in the Pediatric Emergency Department
Background: To evaluate the impact of COVID-19 on evaluations in the pediatric emergency department (ED) because of headache as main symptom.
- Conditions
- COVID-19, Headache Disorders, Emergency Service, Hospital
- Trial name
- NCT06295003
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Migraine
The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol).
- Trial name
- NCT02486276
- Testing
- Cilostazol, Sumatriptan
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Post-dural Puncture Headache
Aminophylline for Patients With Post-Dural Puncture Headache
Post-dural puncture headache (PDPH) is the most common complication of lumbar puncture. Its clinical manifestations are pain in the forehead and the occipital region, or diffuse headache.
- Trial name
- NCT02522013
- Testing
- Aminophylline, isotonic saline
- Where
- 4 sites in China
- Volunteers
- 126 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Tension Headaches, Stress
Temple Massager System Study in Women Ages 35-65
The goal of this observational study is to learn how the Temple Massager System affects stress, emotional wellbeing, sleep, and quality of life in women aged 35 to 65.
- Conditions
- Tension Headaches, Stress, Sleep Quality, Quality of Life
- Trial name
- NCT07639658
- Testing
- Temple Massager System
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Meisch Temple Massager, Inc.
Migraine
A Study of LY3451838 in Participants With Migraine
The reason for this study is to see if the study drug LY3451838 is safe and effective in participants who have migraine that have not responded to other preventive treatments.
- Trial name
- NCT04498910
- Testing
- LY3451838
- Where
- 9 sites in United States
- Volunteers
- 38 people
- Sponsor
- Eli Lilly and Company
Episodic Cluster Headache, Chronic Cluster Headache
Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
This study's hypothesis is the 4mg StatDose sumatriptan is effective for the acute treatment of cluster headache and provides good safety and tolerability across multiple doses of the study medication as well as across multiple…
- Trial name
- NCT00399243
- Testing
- Sumatriptan 4mg Statdose injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Diamond Headache Clinic
Migraine
Efficacy of Fascia Exercises in Migraine Patients
Migraine, which is characterized by attacks and many accompanying symptoms, negatively affects the quality of life of patients. Although different methods have been tried for migraine, there is no definitive treatment approach…
- Trial name
- NCT06231615
- Testing
- Fascia exercises, Conventional physiotherapy and breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Yildirim Beyazıt University
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Migraine Headache
Intranasal Cooling for Symptomatic Relief of Migraine
This study will be a randomised placebo controlled trial examining the effectiveness of using an intranasal cooling device (the RhinoChill) in providing relief of pain and symptoms of acute migraine.
- Trial name
- COOLHEAD2 (NCT02375789)
- Testing
- Active RhinoChill
- Where
- 3 sites in United Kingdom
- Volunteers
- 27 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Acute Migraine
A Study to Learn About the Long-term Safety of Rimegepant for the Acute Treatment of Migraine in Chinese Participants
This trial is to evaluate the long-term safety and tolerability of Rimegepant 75mg ODT in Chinese subjects with migraine
- Trial name
- NCT05371652
- Testing
- Rimegepant 75mg Orally Disintegrating Tablets (ODT)
- Where
- 26 sites in China
- Volunteers
- 241 people
- Sponsor
- Pfizer
Migraine
A Trial of Eptinezumab in Participants With Migraine and Insufficient Response to Anti-CGRP Medications
The main goal of this trial is to learn whether eptinezumab improves migraine symptoms and quality of life of participants with migraine who did not perceive a sufficient improvement during previous treatment with therapies…
- Trial name
- NCT06701526
- Testing
- Eptinezumab
- Where
- 21 sites in United States
- Volunteers
- 164 people
- Sponsor
- H. Lundbeck A/S
Low Back Pain, Headache
Pain Quality Study
One way to better understand how various treatments for pain differ is to determine the effects of these treatments on different pain qualities or characteristics.
- Conditions
- Low Back Pain, Headache, Fibromyalgia
- Trial name
- NCT01321190
- Where
- United States
- Volunteers
- 307 people
- Sponsor
- University of Washington
Migraine
A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder
This study is an open-label, parallel group study to evaluate acute pulmonary safety and Pharmacokinetics (PK) of two doses, separated by 2 hours, of CVT-427 zolmitriptan inhalation powder in three groups of adults: those with…
- Trial name
- NCT02905227
- Testing
- CVT-427 (zolmitriptan inhalation powder)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acorda Therapeutics
Traumatic Brain Injury, Stroke
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury
Background: Previous research has shown that certain parts of the brain are involved in voluntarily stopping an ongoing motor response (movement); however, it is not known whether this same network is also involved in suppressing…
- Conditions
- Traumatic Brain Injury, Stroke, Headache, PTSD
- Trial name
- NCT01194661
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Migraine Disorders
Defining the Sympathetic Skin Response of Migraineurs in the Facial Area
The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation…
- Trial name
- NCT03772860
- Testing
- Pain stimulation, Visual stimulation, Auditory stimulation
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Orofacial Pain, Tension-Type Headache
Photobiomodulation Dosimetry s in Patients With Orofacial Pain
This project aims to validate a dosimetry model for photobiomodulation treatment in patients with orofacial pain and tension-type headache symptoms. The study will involve 240 participants divided into four age groups.
- Trial name
- NCT06065969
- Testing
- Photobiomodulation
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Migraine Disorders
Treatment of Episodic Migraine With AURICular Neuromodulation
Migraine is a ubiquitous pathology affecting approximately 1 billion individuals and being the leading cause of morbidity worldwide before the age of 50.
- Trial name
- MENAURIC (NCT06623188)
- Testing
- Auricular neuromodulation
- Where
- 3 sites in France
- Volunteers
- 106 people
- Sponsor
- Hôpital Européen Marseille
Headache, Headache Disorders
Validity and Reliability of the Dutch HDI
The aim of our study is to investigate the validity and reliability of Dutch version of the Henry Ford Hospital Headache Disability Questionnaire (HDI).
- Conditions
- Headache, Headache Disorders, Neck Pain, Cervical Pain
- Trial name
- NCT05619354
- Testing
- Survey study
- Where
- 2 sites in Belgium
- Volunteers
- 250 people
- Sponsor
- University Ghent
Cyclic Vomiting Syndrome
Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes of stereotypical vomiting.
- Trial name
- NCT04645953
- Testing
- 3mg AZ-010, 1mg AZ010
- Where
- 18 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.