Clinical trials: Headache Disorders, open to volunteers
Pregnancy, Migraine
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women.
- Conditions
- Pregnancy, Migraine, Headache, Postpartum
- Trial name
- NCT06788977
- Testing
- external Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Cefaly Technology
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Migraine
Chronology and Sequence of Premonitory Symptoms
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
- Trial name
- CHRONOpS (NCT07681466)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Migraine
Substance P-Induced Migraine Attacks Without Aura
Substance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura.
- Trial name
- NCT06959004
- Testing
- Substance P
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine With Aura
Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura
Recent data suggest involvement of Acid-Sensing Ion Channel channels in the pathophysiology of migraine making these channels a therapeutic target of migraine disease.
- Trial name
- APAM (NCT04063540)
- Testing
- Amiloride
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cervicogenic Headache
Impact of Adding Jones Technique to Mulligan Therapy in Patients With Cervicogenic Headache
this study will be conducted to investigate impact of adding jones technique to mulligan therapy in patients with cervicogenic headache
- Trial name
- CGH (NCT07047313)
- Testing
- jones and mulligan therapy, mulligan therapy, exercises program
- Volunteers
- 90 people
- Sponsor
- Cairo University
Unrecognized Condition
Evaluate DF-003 in ex Vivo Assays Using Peripheral Blood Mononuclear Cell From Subjects With ROSAH Syndrome
Alpha-1 kinase (ALPK1) has been reported as a potential causative gene for ROSAH Syndrome. Genetic variants including T237M have been found in ROSAH Syndrome patients.
- Trial name
- ROSAH (NCT05319132)
- Testing
- Adult subjects with ROSAH syndrome
- Where
- 5 sites in France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Intracranial Aneurysm, Postoperative Pain
Effect of Bilateral Greater Occipital Nerve Block on Headache After Intracranial Aneurysm Coiling
Postoperative headache is a common complication following endovascular coil embolization of intracranial aneurysms and may increase analgesic requirements, impair patient comfort, and contribute to hemodynamic instability.
- Trial name
- NCT07910864
- Testing
- Ultrasound-Guided Bilateral Greater Occipital Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Konya City Hospital
Migraine
Coping Skills for Migraine: A 6-Month Program
This study aimed to investigate the effects of client-centered coping skills training on pain, quality of life, disability level, and coping skills in individuals with migraine over a 6-month follow-up period.
- Trial name
- NCT07163559
- Testing
- coping skills training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Migraine With Aura, Migraine Aura
Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38
Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) is a key neuropeptide in migraine pathophysiology and treatment.
- Trial name
- NCT07342296
- Testing
- Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38)
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine Disorder, Low Back Pain
Sleep Hygiene Education to Improve Sleep in Chronic Migraine and Back Pain
The goal of this clinical trial is to learn whether sleep hygiene education can improve sleep quality and reduce pain in adults with migraine and/or chronic lower back pain.
- Conditions
- Migraine Disorder, Low Back Pain, Chronic Pain, Sleep Disorder (Disorder)
- Trial name
- NCT07425964
- Testing
- Sleep Hygiene Education
- Volunteers
- 100 people
- Sponsor
- Aalborg University
Migraine Disorders
Specified Drug Use Survey on AJOVY Subcutaneous Injection for Long-term Use
To evaluate the long-term safety of AJOVY in patients under actual use conditions and to specifically evaluate cardiovascular events. In addition, information on efficacy will be collected.
- Trial name
- NCT05342493
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Cervicogenic Headache, Chronic Neck Pain
Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls
The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck.
- Trial name
- NCT07776275
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Migraine
Effect of Manual Therapy on Migraine in Postmenopausal Women
The purpose of the study is to determine the effect of manual therapy on migraine in postmenopausal women.
- Trial name
- NCT07127107
- Testing
- Non-steroidal anti-inflammatory drugs (NSAIDs), Manual therapy techniques
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Migraine
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief.
- Trial name
- NCT06016465
- Testing
- Dexamethasone Oral
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Chronic Migraine, Chronic Migraine, Headache
Efficacy of Nerve Block Versus Botox in Chronic Migraine Management
The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic…
- Trial name
- NCT06684249
- Testing
- Nerve Block Injections, Botulinum Toxin A
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Zagazig University