Clinical trials: Healing Fracture of Bone
Tibial Fractures
Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing
The primary purpose of this study is to perform a high-quality randomized control trial comparing intramedullary tibial nail fixation with standard design nails to a micromotion tibial nail device, to evaluate the rates of union…
- Trial name
- NCT06679049
- Testing
- micromotion intramedullary nail cohort, standard intramedullary nail cohort
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Forearm Injuries, Radius Fractures
Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails
This study looks at children with forearm fractures that need surgery. The standard treatment uses titanium nails, which usually need to be removed in a second operation later.
- Conditions
- Forearm Injuries, Radius Fractures, Ulna Fractures, Fractures, Bone
- Trial name
- FOREST (NCT07536581)
- Testing
- Bioabsorbable intramedullary nail, Titanium elastic intramedullary nail
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Children's Fractures Interest Group, Denmark
Ankle Fractures
Impact of Suture Technique on Wound Healing in Ankle Fracture Surgery: A Randomized Controlled Trial
Our primary aim is to compare the complication rates of patients with ankle fractures who underwent skin closure using a running subcuticular suture pattern compared to an interrupted suture pattern.
- Trial name
- NCT06496698
- Testing
- Simple Interrupted Suture, Subcuticular Suture
- Volunteers
- 80 people
- Sponsor
- University of Puerto Rico
Focus: Smoking Cessation as it Relates to Fracture Healing
Smoking Cessation Intervention Within the Fracture Clinic
Tobacco use is the leading preventable cause of death contributing to more than 5 million estimated deaths per year globally. The longterm negative effects of smoking are well established.
- Trial name
- NCT02891265
- Testing
- Smoking cessation patch
- Where
- 2 sites in Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Fractured Mandible Due to Trauma
The Impact of ESWT on Healing of Fractured Mandible
studying if using extracorporeal radial shockwave therapy as an adjuvant therapy help in accelerating the bone healing and regeneration in mandibular fractures by comparing it with the standard protocol for fractures fixation by…
- Trial name
- NCT06363188
- Testing
- Radial Extracorporeal shockwave
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Fracture of Pelvis (Disorder)
Abaloparatide and Pelvic Fracture Healing
This is a prospective randomized, double-blinded, placebo-controlled, phase 2, three-month study of the efficacy of abaloparatide in postmenopausal women and men ≥ 50 years of age with acute fractures of the pelvis (n=78).
- Trial name
- NCT04249232
- Testing
- Abaloparatide 80 micrograms per Pen dose
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Hospital for Special Surgery, New York
Bone Nonunion
Clinical Study of Umbilical Cord Blood Mononuclear Cells (UCB-MNCs) in the Treatment of Traumatic Fracture Healing
The aim of this study is to explore the effectiveness and safety of umbilical cord blood mononuclear cells in promoting traumatic fracture healing.
- Trial name
- NCT04997590
- Testing
- Umbilical cord blood mononuclear cells, Staphylococcal Enterotoxin C
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qianfoshan Hospital
Fracture Fixation, Intramedullary, Forearm Fracture
Use of the Bioabsorbable Activa IM-Nail™ in Pediatric Diaphyseal Forearm Fractures
Background Pediatric diaphyseal forearm fractures are common and one of the most frequent reasons for orthopedic care. Fractures in need of surgery are often treated with metal Elastic Stable Intramedullary Nails (ESIN).
- Conditions
- Fracture Fixation, Intramedullary, Forearm Fracture, Fracture Healing, Child, Only
- Trial name
- NCT04941612
- Testing
- Activa IM-Nail
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Children's Fractures Interest Group, Denmark
Microcirculation, Wound Healing
Hyperbaric Oxygen Therapy in Calcaneal Intraarticular Fractures: Can it Decrease the Soft-tissue Complication Rate?
This study aims to test the hypothesis that postoperative daily hyperbaric oxygen therapy (HBOT) decreases soft-tissue complication rate during the operative handling of intra-articular calcaneal fractures. Minor motivations: 1.
- Trial name
- HOCIF (NCT01264146)
- Testing
- HBOT
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Fracture, Ankle
Ankle Fractures Treated With Teriparatide
This is a single site feasibility trial to test whether daily administration of Teriparatide, in participants with Weber type B ankle fractures that are being conservatively managed, is superior to the standard care treatment…
- Trial name
- NCT02955056
- Testing
- Forsteo
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Fractures, Bone, Upper Extremity Injury
Ultrasonography in Fracture Management
The bone fracture is usually diagnosed using an X-ray examination (the method of choice). However, in the case of the youngest patients (children and adolescents), it carries a potential risk of X-ray radiation exposure.
- Conditions
- Fractures, Bone, Upper Extremity Injury, Healing Fracture of Bone, Vascularization
- Trial name
- UFrac (NCT04501510)
- Testing
- Ultrasonographic examination validation and testing
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- University of Warmia and Mazury
Ankle Fractures, Trauma Injury
Effect of Toradol on Post-operative Foot and Ankle Healing
The use of Toradol for pain control in surgical orthopedic cases is currently a topic of interest within the field. The proposed study is a prospective randomized study evaluating postoperative pain, opioid requirement…
- Trial name
- NCT03727048
- Testing
- Ketorolac, No ketorolac
- Volunteers
- 128 people
- Sponsor
- Rothman Institute Orthopaedics
Maxillofacial Trauma
Assessment of Healing Properties Using Hyaluronic Acid Topical Application in Parasymphyseal Fracture Fixation: A Randomized Clinical Trial
HA is favorable for osteogenesis, enhancing bone growth, acting a vector for osteoinductive compounds and promoting even distribution and increased density of newly formed bone, thereby altering the scaffold morphology and…
- Trial name
- NCT06221527
- Testing
- conventional group
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Proximal Humeral Fracture
Non-operative Treatment in Sweden of Proximal Humeral Fractures
Proximal humeral fractures are common especially in the elderly population. The majority of these fractures are minimally displaced and may be treated non-operatively.
- Trial name
- NOSWEPH (NCT03786679)
- Testing
- Ultrasling ER III orthosis
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lars Adolfsson
Radius Fracture
A Study to Evaluate the Safety and Effectiveness of Different Doses of Chrysalin in Adults Who Have a Broken Wrist
The purpose of this study is to evaluate the safety of Chrysalin, also known as TP508, and to determine the effectiveness of four doses of Chrysalin for treating broken wrists in adults.
- Trial name
- NCT00131482
- Testing
- Chrysalin
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Capstone Therapeutics
Femoral Shaft Fracture, Tibial Shaft Fractures
Rehabilitation After Lower Extremity Nailing Trial
The goal of this clinical trial is to learn if outpatient physical therapy (PT) results in differing functional outcomes compared to a self-guided home exercise program (HEP) in tibial or femoral nail patients.
- Trial name
- ReLENT (NCT07783568)
- Testing
- Formal Physical Therapy (PT), Home Exercise Program (HEP)
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Fracture Healing in HIV-positive Patients
HIV in Orthopaedic Skeletal Trauma Study
Adult patients > 18 years with fresh (within 2 weeks of injury), closed and open, tibia and femur fractures who undergo IM nailing for fracture fixation will be eligible for the study.
- Trial name
- HOST (NCT03131947)
- Testing
- HIV positive patients
- Where
- South Africa
- Volunteers
- 420 people
- Sponsor
- Wellcome Trust Liverpool Glasgow Centre for Global Health Research
Fractures
The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures
This randomized, placebo-controlled study will evaluate the effectiveness of the adjunctive use of teriparatide for the healing of Jones fractures.
- Trial name
- NCT01173081
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio Orthopedic Center of Excellence
Fracture, Closed, Comminuted, Healing
Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral Extension
Treatment of lateral fractures of the clavicle is challenging and has been controversially discussed for a long time due to high non-union rates in non-operative treatment and high complication rates in surgical treatment.
- Trial name
- LatClav (NCT02256059)
- Testing
- Plate osteosynthesis
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Fracture Healing
A Phase IIa Study Of Men And Post-Menopausal Women With A Fractured Distal Radius
This is a study designed to test the safety and effectiveness of SB-751689 in the treatment of a distal radius fracture in post-menopausal women and men in comparison to placebo to determine if healing time of the fracture can be…
- Trial name
- NCT00548496
- Testing
- SB-751689
- Where
- 37 sites in Argentina, Australia and 11 more
- Volunteers
- 86 people
- Sponsor
- GlaxoSmithKline