Clinical trials: Healing Fracture of Bone
Fragility Fracture, Femur; Fracture, Pertrochanteric
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.
This study is being conducted with the aim of comparing the time to bone healing after surgery for fragility fractures of proximal femur between patients receiving strontium ranelate and placebo.
- Conditions
- Fragility Fracture, Femur; Fracture, Pertrochanteric, Clinical Trial
- Trial name
- STRONG (NCT05712616)
- Testing
- Strontium Ranelate, Lacto-N-Hexaose
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Orthopaedic Trauma Infections
BBOT: Bacterial Burden in Ortho Trauma Procedures
The purpose of this research project is to improve understanding of the potential role of highly sensitive bacterial tests in diagnosing infected non-healing fractures compared to the current standard of care, microbiologic…
- Trial name
- NCT03126448
- Testing
- Highly Sensitive Assays
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hip Fracture
Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing
Osteoporotic hip fracture is common in elderly. As a result of aging population in Hong Kong, the total number of hip fracture cases is anticipated to increase substantially in the future, and therefore draw more resources in…
- Trial name
- NCT01293721
- Testing
- Low-magnitude high - frequency vibration treatment
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
Fracture, Closed, Comminuted, Healing
Effect of Low-Magnitude, High Frequency Vibration Treatment on Femoral Shaft Fracture Healing
Diaphyseal long bone fractures are usually associated with high energy trauma in which femoral shaft fracture is one common fracture in young age group.
- Trial name
- NCT01386749
- Testing
- vibration platform provide low magnitude and high frequency vibration treatment, which is self-developed by our research team
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Stress, Psychological, Telomere Shortening
Biological and Behavioral Outcomes of Community Nature Walks
The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial/ethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities…
- Conditions
- Stress, Psychological, Telomere Shortening, Stress Reaction
- Trial name
- NCT06056375
- Testing
- Reclaiming Nature Intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charlotte Tate
Healing of Fracture
Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
The investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.
- Trial name
- NCT01626625
- Testing
- stem cells + hydroxy apatite, autograft taken from iliac crest
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Pars Interarticularis Stress Fracture, Pars Interarticularis Stress Injury
Pars Healing on MRI
The goal of this clinical trial is to learn more about the natural healing process of pars stress injuries in adolescents and young adults by documenting bony bridging across stress fractures using Magnetic Resonance Imaging…
- Trial name
- NCT07215845
- Testing
- MRI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Vitamin D, Long Bone Fracture
Longitudinal Study of Patients Following Long Bone Fracture
Studies in chickens show that blood levels of a particular form of vitamin D (called 24,25-dihydroxvitamin D) increase after bone fracture.
- Trial name
- NCT01170572
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Barts & The London NHS Trust
Delayed Union After Fracture of Humerus, Tibial or Femur
Evaluation of Efficacy and Safety of Autologous MSCs Combined to Biomaterials to Enhance Bone Healing
Bone grafting is widely used in hospitals to repair injured, aged or diseased skeletal tissue. In Europe, about one million patients encounter a surgical bone reconstruction annually and the numbers are increasing due to our…
- Trial name
- OrthoCT1 (NCT01842477)
- Testing
- Implantation of bone substitute plus autologous cultured mesenchymal cells
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mandibular Fracture Treatment
Inter Flex Three Dimensional Plate in Management of Mandibular Fracture RCT
The goal of this clinical trial is to learn if The use of a 3D-designed Inter-flex plate will achieve safe and desirable anatomical \& functional restoration with reduced operative time in mandibular fracture, Improvement of…
- Trial name
- NCT07263893
- Testing
- Group I :site with mandibular fracture will be treated with custom made Inter-flex three dimensional plate in site of mandibular fracture
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Achilles Tendon Rupture, Ankle Fractures
Swedish Multicenter Trial of Outpatient Prevention of Leg Clots
Lower limb immobilization is associated with high risk of complications, i.e. venous thromboembolism (VTE) and failed healing. Pharmacoprophylaxis of VTE is in leg-immobilized patients, however, low- or non-effective and…
- Conditions
- Achilles Tendon Rupture, Ankle Fractures, Venous Thromboembolism
- Trial name
- StopLegClots (NCT03259204)
- Testing
- Adjuvant IPC
- Where
- Sweden
- Volunteers
- 1,400 people
- Sponsor
- Karolinska University Hospital
Malunion of Fracture of Radius
Evaluating the Utility of Bone Grafts in Open Wedge Corrective Osteotomy and Plate Fixation
INTRODUCTION A variety of bone grafts and substitutes are available for filling bone defects in the distal radius after corrective osteotomy, but the harvesting of bone from the iliac crest is the gold standard as it allows easy…
- Trial name
- WOPPeR (NCT06093763)
- Testing
- Group without bone grafting, Group with bone grafting
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Forearm Fracture, Clavicle Fracture
Bone Ultrasound to Access Fracture Healing
The purpose of this study is to evaluate sequential fracture healing with radius/ulna fractures or clavicle fractures and compare ultrasound to radiographs.
- Trial name
- NCT02769117
- Testing
- Ultrasound on fractured bone, Ultrasound on contralateral intact bone
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Tibial Fractures
Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT03826784
- Testing
- BHA
- Where
- United States
- Sponsor
- Carmell Therapeutics Corporation
Distal Radius Fractures
A Study Comparing the Effect of Amorphous Calcium Carbonate (ACC) on Healing Time of Distal Radius Fractures
Amorphical has a strong basis to believe that the Amorphous Calcium Carbonate (ACC) product has an effect on active mineralization during bone remodelling hence, it has a potential to accelerate fracture healing process.
- Trial name
- NCT01859468
- Testing
- Amorphous calcium carbonate
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Amorphical Ltd.
Ankle Fractures
Postoperative Aspirin and Ankle Fracture Healing
This study aims to identify if postoperative aspirin use leads to a delay in fracture healing. NSAIDs have long been avoided in the management of fractures, due to the belief that they may impair fracture healing.
- Trial name
- NCT03765619
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Femoral Neck Fracture, Hip Fracture
A Focused Registry on the Femoral Neck System (FNS) in Patients With Femoral Neck Fractures
In comparison to previous implants, the Femoral neck system (FNS) is an approved implant by the competent authorities (CE mark). It is designated to stabilize medial femoral neck fractures in a minimal invasive technique.
- Trial name
- FR_FNS (NCT02422355)
- Testing
- FNS
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 125 people
- Sponsor
- AO Innovation Translation Center
Shoulder Fractures, Trochanteric Fractures
Effect of PTH(1-34) Treatment on Fracture Healing in Vivo
The purpose of the study is to investigate, whether PTH(1-34) is able to promote fracture healing in postmenopausal women with fractures of the hip or shoulder.
- Trial name
- NCT00741182
- Testing
- rhPTH(1-34)
- Where
- Denmark
- Sponsor
- Glostrup University Hospital, Copenhagen
Bone Fracture
Bone Healing Study
The aim of the research is to identify structural tissue changes in the early fracture hematomas.
- Trial name
- NCT03244969
- Where
- Russia
- Sponsor
- Kazan Federal University