Clinical trials: Health Care Associated Infection
Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and
Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAP
Reporting patterns and results of initial antibiotic treatment in patients with complicated urinary tract infection (cUTI), complicated intra-abdominal infection (cIAI) and nosocomial pneumonia (NP) including…
- Conditions
- Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and, Nosocomial Pneumonia (NP)
- Trial name
- RECOMMEND (NCT02364284)
- Where
- 27 sites in Brazil, France and 4 more
- Volunteers
- 1,322 people
- Sponsor
- Pfizer
Ventilator-associated Pneumonia, Ischemic Stroke
Effect of Atorvastatin on the Frequency of Ventilator-associated Pneumonia in Patients With Ischemic Stroke
Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in ventilated critically ill patients specially in intensive care unit (ICU).
- Trial name
- NCT01550419
- Testing
- Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Minhang Central Hospital
Sepsis, Bacterial Infections
Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment.
- Conditions
- Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection
- Trial name
- IDEAS-CRXO (NCT06103500)
- Testing
- Clinical Decision Support Algorithm for Empiric Antibiotics in Sepsis
- Where
- 3 sites in Canada
- Volunteers
- 1,478 people
- Sponsor
- Ottawa Hospital Research Institute
Herpes Zoster
Measuring Herpes Zoster and PHN Associated Burden of Illness and Health Care Utilization Costs in Thailand
Total 7 institutions will be recruited i.e. Clinical Infectious Disease Research Unit Department of Clinical Tropical Medicine, Faculty of Tropical Medicine Mahidol University,Bamrasnaradura Infectious Disease Institute…
- Trial name
- NCT00526864
- Where
- Thailand
- Volunteers
- 180 people
- Sponsor
- Mahidol University
Cystic Fibrosis, Pseudomonas Aeruginosa
Cross Transmissions of Pseudomonas Aeruginosa Between Children From a Same Cystic Fibrosis Center.
Cystic fibrosis is the most common hereditary autosomal recessive disease in the Caucasian population. The diseases is caused by a mutation of the gene coding for the CFTR protein (Cystic fibrosis transmembrane conductance…
- Conditions
- Cystic Fibrosis, Pseudomonas Aeruginosa, Cross Infection
- Trial name
- PAPED (NCT03910920)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Queen Fabiola Children's University Hospital
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bacterial Respiratory Infections
Microdosing of BAC ONE to the Distal Lung
Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which…
- Trial name
- BAC ONE (NCT02558062)
- Testing
- BAC ONE administration
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Nosocomial Infections, Pneumonia, Ventilator-Associated
A Efficacy and Safety Study of Nasal Prongs With Proprietary Surface Coating Aiming to Reduce Bacterial Colonization
The study is a first step in establishing the safety and efficacy of the CytaCoat technology when applied to a medical device such as a nasal prong and the clinical data generated will serve as a basis for continuous studies in…
- Trial name
- NCT02756351
- Testing
- CytaCoat Nasal Prong, Inspiration Healthcare Inspire nCPAP Nasal Prong
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- CytaCoat AB
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Hospital-acquired Pneumonia
Impact of Antimicrobial Stewardship on Outcomes of Patients With Hospital-acquired Pneumonia Due to Gram-negative Bacilli - A Before-after Study
Hospital-acquired pneumonia (HAP) is one of the most frequent complications and the main cause of antibiotics use in hospitalized patients, particularly in intensive care units (ICUs).
- Trial name
- ORACLE (NCT04937075)
- Testing
- No intervention
- Where
- 2 sites in France
- Volunteers
- 420 people
- Sponsor
- Nantes University Hospital
Cross Infection
Randomized Pilot Study Evaluating Isopropyl Alcohol and UVC Rays in Disinfection of Cell Phones
Cell phones have become a fundamental accessory of our lives and clinical practice, often kept in contact with the body. Since most modern smartphones are equipped with touch screens, they can serve the function of reservoirs for…
- Trial name
- SaniPhone (NCT06194903)
- Testing
- isopropyl alcohol wipes, UVC box
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Staphylococcus Aureus
Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making
The study EPICS-6 consists of three study phases. Emergency Department patients are screened for nasal and pharyngeal colonisation with Methicillin sensitive and Methicillin resistant Staphylococcus aureus (MSSA/MRSA) using a…
- Trial name
- EPICS-6 (NCT03220386)
- Testing
- Decolonization by nasal Octinidin treatment and skin washings
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Covid19, Nosocomial Infection
Treatment of Nosocomial COVID-19
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. Nosocomial acquisition of SARS-CoV-2 is a frequent concern across hospital settings in Canada and is…
- Conditions
- Covid19, Nosocomial Infection, SARS-CoV2 Infection
- Trial name
- CATCO-NOS (NCT04748588)
- Testing
- Anti-SARS-CoV-2 mAb
- Where
- 4 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Health Care Associated Infection
Water Hygiene Versus Waterless Hygiene Technology for Totally Dependent Hospitalized Patients
The aim of this randomized controlled trial is to verify whether the efficacy of perineal hygiene procedures performed in dependent patients admitted to medical or geriatric wards with pre-moistened wipes without water is higher…
- Trial name
- IGIENE-FAST (NCT06514131)
- Testing
- Pre-moistened wipes
- Where
- 4 sites in Italy
- Volunteers
- 468 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Abdominal Abscess
Study Comparing Tigecycline and Imipenem/Cilastatin in Chinese Subjects With Complicated Intra-Abdominal Infections
The primary objective of this study is to compare the safety and efficacy of an experimental antibiotic to a marketed antibiotic in the treatment of Chinese subjects with complicated intra-abdominal infections. <br />
- Trial name
- NCT00136201
- Testing
- tigecycline
- Where
- 11 sites in China
- Volunteers
- 200 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cross Infection, Infection Control
A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates
Sepsis contributes to nearly 20% of all hospital deaths and is the leading cause of death on non-coronary intensive care units. Contamination of the patient environment is common with organisms such as MRSA, VRE and C.difficile…
- Trial name
- NCT01245829
- Testing
- Swabbing of observation chart
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- County Durham and Darlington NHS Foundation Trust
Patients at High Risk of Antibacterial Treatment Upon Admission
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens
Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide.
- Trial name
- PILGRIM (NCT03765528)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital of Cologne
Nosocomial Infection, Respiratory Tract Infection
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
- Conditions
- Nosocomial Infection, Respiratory Tract Infection, Surgical Site Infection
- Trial name
- NCT00272675
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP)
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients.
- Conditions
- Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal
- Trial name
- NCT07375667
- Testing
- The dynamics of airway resistance, conventional suctioning
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Affiliated Hospital of Nantong University
Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome
Clinical and Biological Markers in Acute Respiratory Failure
In a recent experimental study, the investigators showed that the growth factor Activin A is expressed in the lungs of rats with the acute respiratory distress syndrome (ARDS) at levels that are comparable with those determined…
- Trial name
- NCT02019095
- Testing
- Bronchoscopy for the sampling of bronchoalveolar lavage (BAL) fluid
- Where
- 2 sites in Greece
- Volunteers
- 55 people
- Sponsor
- University of Athens