Clinical trials: Health Volunteer
Healthy Volunteers
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health Volunteers
Background: Rivaroxaban and apixaban are blood thinners. People with HIV may need to take them to treat or prevent blood clots. The anti-HIV drug darunavir (DRV) can increase the amount of these blood thinners in the body.
- Trial name
- NCT03864406
- Testing
- Cobicistat, Darunavir/Cobicistat, Rivaroxaban
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Frailty
Effect of an Exercise Program for Frail Older Adults
Despite the high level of evidence for physical activity as a countermeasure for frailty, the current Flemish standard of care does not include structural PA interventions for community-dwelling frail older adults.
- Trial name
- AA@HOME (NCT05946109)
- Testing
- ACTIVE-AGE@home
- Where
- Belgium
- Volunteers
- 195 people
- Sponsor
- Universitair Ziekenhuis Brussel
Community Health Services, Telemedicine
Using mHealth Tools to Deliver Integrated Community Case Management (ICCM) to Village Health Team (VHT) Volunteers.
This study compares the traditional, didactic method of training Ugandan community health workers with training using tablets in pneumonia management, a common, life-threatening illness in children in rural areas.
- Trial name
- NCT02971449
- Testing
- Amazon Fire Tablet, ICCM Traditional Trainins
- Where
- 2 sites in United States, Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Omni Med
Cardiometabolic Health
Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
The trial was a double-blind randomized dietary intervention study with a 1:1 allocation ratio, conducted in accordance with the Declaration of Helsinki.
- Trial name
- NCT05417191
- Testing
- Conventional fish, Enriched fish
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Cardiovascular Diseases, Diabetes
Diabetes and Heart Disease Risk in Blacks
It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart…
- Conditions
- Cardiovascular Diseases, Diabetes, Obesity, Hypertension
- Trial name
- NCT00001853
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Neonatal Death, Perinatal Death
CHV-NEO: Community-based Digital Communication to Support Neonatal Health
Neonatal mortality (defined as death in the first 28 days of life) remains unacceptably high in sub-Sarahan Africa. The concentrated risk of neonatal illness in the first weeks of life and its potential to rapidly deteriorate…
- Trial name
- NCT05187897
- Testing
- CHV-NEO
- Where
- Kenya
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Volunteers
Spire Health Remote Patient Monitor Human Factors Summative Study Protocol
This usability validation testing protocol outlines the methods being used to demonstrate and gather evidence that the current design and user experience of the Spire Remote Patient Monitor are safe and effective for use by the…
- Trial name
- NCT06395350
- Testing
- Spire Health Monitor
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Spire, Inc.
Chinese Healthy Volunteer
Safety and Pharmacokinetic Study of ARTS-011 in Chinese Healthy Volunteers
This single- and multiple-ascending dose study is a Phase 1, first in human study of ARTS-011. The goal of the study is to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of ARTS-011 after…
- Trial name
- NCT06260527
- Testing
- ARTS-011
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Allorion Therapeutics Inc
Healthy, Psychedelic Experiences
Consciousness, Psilocybin, and Well-Being
This study is being done to identify a dosing strategy that will allow IV psilocybin to be administered to sleeping participants without awakening them.
- Conditions
- Healthy, Psychedelic Experiences, Sleep
- Trial name
- CoPE Pilot (NCT05592379)
- Testing
- Psilocybin, Clonidine, Saline
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Covid19, Severe Acute Respiratory Syndrome
Safety and Tolerability of COVID-19 Vaccine (ABNCoV2)
This phase 1 trial aims to assess the safety and tolerability of two doses of ABNCoV2, formulated with and without the adjuvant MF59, in healthy adult volunteers and to identify the dosage and formulation that optimizes the…
- Conditions
- Covid19, Severe Acute Respiratory Syndrome, SARS-CoV-2 Infection
- Trial name
- COUGH-1 (NCT04839146)
- Testing
- ABNCoV2 Vaccine
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Health Volunteer
A Pharmacokinetic Study of JS002 in Healthy Subjects
This study was a single-center, randomized, open-label, single-dose, parallel-controlled trial design conducted in healthy adult subjects.
- Trial name
- NCT05859529
- Testing
- JS002
- Where
- China
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Enterovirus Infection
A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine
This study is aims to evaluate the safety, reactogenicity and immunogenicity of EV71 vaccine at a 0.25ml or 0.5ml dose in health volunteers
- Trial name
- NCT01268787
- Testing
- EV71 vaccine
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Tobacco Dependence
Single-dose Pharmacokinetics of Oral Nicotine Replacement Products
This is an explorative study comparing new prototypes of Nicotine Replacement Products with Nicorette® gum.
- Trial name
- NCT01228617
- Testing
- Nicotine, Nicotine Gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Healthy Volunteer
Neuroeconomic Approach of Food Nutritionnal Assesment
This fMRI study evaluated the cognitive mechanisms and the cerebral substrate of decision making when evaluating the healthiness of food products with nutritional information displayed either with a Traffic Light system, a…
- Trial name
- NeuroFood (NCT02841410)
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Good Health
SF2000SD Clinical Trial in Zambia
The purpose of this study is to assess the safety and tolerability of SF2000SD in adult male healthy volunteers
- Trial name
- SF2000SD (NCT02941159)
- Testing
- SF2000SD
- Where
- Zambia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Tropical Diseases Research Centre, Zambia
Medication Adherence, HIV
Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
This is a single-center, open label study to identify adherence levels of commonly prescribed FDA-approved antiretroviral agents by tracking the decline of drug concentrations in plasma, urine and saliva following abrupt drug…
- Trial name
- APTAMER (NCT04302896)
- Testing
- dolutegravir oral tablet 50mg, emtricitabine/tenofovir alafenamide oral tablet 200mg/25mg, tenofovir disoproxil fumarate oral tablet 300mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rhonda Brand
Healthy Volunteers
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
Background: Human intestines are home to a complex gut flora, also called microbiome; this is a natural occurring community of bacteria, fungi, yeast, and viruses.
- Trial name
- NCT06615986
- Testing
- Cardiosyn
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Renal Anemia
Pharmacokinetics Comparison Study of JT1801 and NESP® After Single Dose Administration in Chinese Health Male Volunteers
The purpose of this study is to compare the similarity of major pharmacokinetic parameters after a single intravenous administration of JT1801 and NESP® in chinese healthy male volunteers.
- Trial name
- NCT05864261
- Testing
- JT1801 60ug, NESP 60ug
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yi Fang
Smoking Cessation
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4041 in Healthy Volunteers
This is a Phase I, first-in-human (FIH), single-center, randomized, double-blind, placebo controlled, single ascending dose, sequential group study in healthy vasectomized male and female subjects of non-childbearing potential…
- Trial name
- NCT04076540
- Testing
- AZD4041
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type2 Diabetes Mellitus
Continuous Multiple Dose PB-119 Injection in Health Volunteers
This is an open label, multiple dose study, pharmacokinetic and pharmacodynamics studies will be performed at the same time with tolerability study.
- Trial name
- NCT03062774
- Testing
- PB-119 injection
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- PegBio Co., Ltd.