Clinical trials: Healthcare-Associated Infections
Ventilator Associated Pneumonia
Pravastatin and Ventilatory Associated Pneumonia
Statins present anti-inflammatory and immunomodulatory effects. They may modify the regulation of cytokines, (released from the cellular damage) and may reduce the production of C-reactive protein levels.
- Trial name
- EPRAVAP (NCT00702130)
- Testing
- Pravastatin
- Where
- 2 sites in Greece
- Volunteers
- 152 people
- Sponsor
- University of Thessaly
Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation
Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)
The goal of this observational study is to support U.S. healthcare centers in determining if they may have an NTM outbreak among patients receiving care at the healthcare center.
- Conditions
- Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation, Healthcare Associated Infection, Mycobacterium Infections
- Trial name
- TrANsMIt (NCT06155747)
- Testing
- Epidemiologic investigation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Community-Acquired Infection, Cross Infection
Computerized Decision Support System for Antibiotic Treatment
We developed a computerized decision support system for prescription of antibiotics to inpatients. The purpose of the study is to assess the performance of the system in different wards, in three different hospitals, in three…
- Trial name
- NCT00233376
- Testing
- Access to an antibiotic decision support system, Distribution of local antibiotic guidelines
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Rabin Medical Center
Urinary Tract Infection, Nosocomial Infection
Effect of Chlorhexidine on Bacteriuria
This study is conducted to determine and compare the effect of applying Povidone-iodine and Chlorhexidine solutions for perinea washing on bacteriuria rate and type in patients with urinary catheter in intensive care unit.
- Conditions
- Urinary Tract Infection, Nosocomial Infection, Bacteriuria
- Trial name
- NCT02032394
- Testing
- Povidone-iodine, Chlorhexidine, Normal saline
- Where
- Iran
- Volunteers
- 105 people
- Sponsor
- Mashhad University of Medical Sciences
Methicillin-Resistant Staphylococcus Aureus
Gown and Glove Use to Prevent the Spread of Infection in VA Community Living Centers
Methicillin-resistant S. aureus (MRSA) infections are a common cause of morbidity and mortality in nursing home residents. MRSA is predominantly spread from patient-to-patient by health care workers.
- Trial name
- NCT01350479
- Where
- 7 sites in United States
- Volunteers
- 203 people
- Sponsor
- VA Office of Research and Development
Neonatal Infection
Effect of Chlorhexidine Versus Alcohol on Infections in Neonates
Chlorhexidine is a local antiseptic that has an important role in the prevention of catheter-associated bloodstream infections. Its application to a newborn's umbilical cord reduces all-cause neonatal mortality.
- Trial name
- NCT06194396
- Testing
- chlorhexidine, alcohol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Hospital Acquired Pneumonia
Predictors and Outcomes of Ventilated Hospital-acquired Pneumonia
Hospital-acquired pneumonia (HAP) is defined as an infection of the pulmonary parenchyma that develops in patients admitted to hospital for more than 48 hours and that was not incubating at the time of admission.
- Trial name
- NCT07667582
- Testing
- mechanical ventilation (MV)
- Where
- Egypt
- Volunteers
- 151 people
- Sponsor
- Assiut University
Healthcare Associated Pneumonia
Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia
Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the management of health-care associated pneumonia (HCAP).
- Trial name
- NCT01966796
- Where
- Taiwan
- Volunteers
- 530 people
- Sponsor
- Far Eastern Memorial Hospital
Methicillin Resistant Staphylococcus Aureus (MRSA)
Nosocomial Pneumonia With Suspected Or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA)
To determine if linezolid is superior to vancomycin in the treatment of nosocomial (acquired in the hospital) pneumonia due to Methicillin Resistant Staphylococcus Aureus (MRSA) in adult subjects.
- Trial name
- ZEPHYR (NCT00084266)
- Testing
- linezolid (Zyvox), vancomycin
- Where
- 177 sites in United States, Argentina and 20 more
- Volunteers
- 1,225 people
- Sponsor
- Pfizer
Post-operative Complications, Surgical Site Infection
The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions
The purpose of this study is to compare the post-surgical standard-of-care dressing to the Prevena™ Incision Management System in women undergoing Cesarean section surgery.
- Conditions
- Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
- Trial name
- NCT01450631
- Testing
- Prevena™ Incision Management System (PIMS), Standard-of-care Dressing
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- KCI USA, Inc
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Nosocomial Infections
Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation
Nosocomial infection with antibiotic-resistant strains is a major threat to critical care medicine. Selective decontamination of the digestive tract (SDD) is one of the strategies to reduce ventilator associated pneumonia and…
- Trial name
- LFasSDD (NCT01535170)
- Testing
- bovine Lactoferrin
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- China Medical University Hospital
Healthy Volunteer
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers
The current Phase I clinical trial has been developed to assess the safety and tolerability of the Fluorothyazinone drug used as a single-dose administration and a treatment course in healthy volunteers.
- Trial name
- NCT03205462
- Testing
- Fluorothyazinone 300 mg, Fluorothyazinone 600 mg, Fluorothyazinone 3900 mg
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Ventilator Associated Pneumonia, Infections
Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
Probiotics are commercially available live bacteria thought to have health benefits when ingested. A literature review of probiotic studies in the intensive care unit (ICU) found that in patients who receive probiotics, there is…
- Conditions
- Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea
- Trial name
- PROSPECT (NCT02462590)
- Testing
- L. rhamnosus GG - Probiotic
- Where
- 44 sites in United States, Canada and 1 more
- Volunteers
- 2,650 people
- Sponsor
- McMaster University
Ventilator Associated Pneumonia
Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)
The study is designed to evaluate sensitivity, specificity and accuracy of non-bronchoscopic bronchoalveolar lavage and endotracheal aspirate in comparison with bronchoscopic bronchoalveolar lavage (gold standard), as methods for…
- Trial name
- NCT02363023
- Testing
- Collect tracheal and pulmonary secretions
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Hand Hygiene Compliance
Tailor VHA HH Bundle for Acute Mental Health Care
Mental health settings are particularly vulnerable to outbreaks and transmission due to infectious pathogens like norovirus. This occurs since access to soap and water (sinks) is limited for safety reasons and alcohol hand rub is…
- Trial name
- NCT07607145
- Testing
- Tailored Hand Hygiene Bundle, Non-Alcohol Based Hand Sanitizer
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Ventilator-associated Pneumonia
Nebulized and Intravenous Colistin in Ventilator Associated-pneumonia
Few antimicrobials are available to treat ventilated associated pneumonia (VAP) caused by Gram negative multi-resistant (MDR) bacteria. Colimycin often remains the only active antibiotic.
- Trial name
- COLIVAP (NCT02906722)
- Testing
- Intravenous colimycin, Nebulized colimycin
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Acquired Pneumonia, Hospital Acquired Pneumonia
Steriwave ICU Pilot Study
This is a single-center, non-blinded, prospective, pilot study enrolling patients admitted to the critical care unit at Royal Columbian Hospital.
- Conditions
- Ventilator Acquired Pneumonia, Hospital Acquired Pneumonia, Hospital Acquired Infections, Nasal Decolonization of Staphylococcus Aureus
- Trial name
- NCT06867458
- Testing
- Antimicrobial photodynamic therapy (aPDT) nasal decolonization device
- Where
- Canada
- Volunteers
- 227 people
- Sponsor
- Fraser Health