Clinical trials: Healthcare-Associated Infections
Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between…
- Trial name
- HOMI-LUNG-HAP (NCT06602934)
- Testing
- Blood samples, Oropharyngeal swabs, ECG
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Influenza, Influenza Prophylaxis
Oseltamivir and Baloxavir Marboxil for Prophylaxis Against Influenza Under a Hospital-based Setting
This study aims to randomly assign close contacts of hospitalized influenza virus patients to receive baloxavir marboxil prophylaxis, oseltamivir prophylaxis or no antiviral prophylaxis and monitor the incidence of clinical…
- Conditions
- Influenza, Influenza Prophylaxis, Nosocomial Infection
- Trial name
- NCT06762587
- Testing
- Baloxavir Marboxil, Oseltamivir
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Ventilator Associated Pneumonia, Oral Hygiene
Effects of Oral Care in the Neuroscience ICU
The purpose of this study is to compare how effective different ways of mouth cleaning are for patients in a neuroscience intensive care unit with a breathing tube in their mouth.
- Trial name
- NCT00518752
- Testing
- Standard Oral Care, Comprehensive Oral Care
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Infection, Pneumonia
Infection Surveillance in Intensive Care Patients
Purpose of the study is to investigate and quantify known and possible new riskfactors for nosocomiel infection and death in the intensive care setting.
- Conditions
- Infection, Pneumonia, Sepsis, Cross Infection
- Trial name
- NCT00197847
- Where
- Denmark
- Volunteers
- 549 people
- Sponsor
- Herlev Hospital
Pneumonia
Ceftobiprole in Hospital Acquired Pneumonia
The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril (the water-soluble prodrug [form] of ceftobiprole) referred to as ceftobiprole versus a comparator in the treatment of patients with…
- Trial name
- NCT00229008
- Testing
- linezolid plus ceftazidime
- Volunteers
- 106 people
- Sponsor
- Basilea Pharmaceutica
Respiratory Insufficiency, Ventilator-associated Pneumonia
Biofilm Formation on Different Endotracheal Tube Materials
Three endotracheal tubes (ETTs) with different surfaces properties will be studied regarding formation and structure of the biofilm formed on those ETTs.
- Trial name
- NCT02284438
- Testing
- Endotracheal tube
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Ventilator Associated Pneumonia, Lung Ultrasound
Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia
To evaluate the sensitivity, specificity and diagnostic accuracy of bedside transthoracic ultrasound examination in the diagnosis and follow up of ventilator associated pneumonia.
- Trial name
- NCT04057625
- Testing
- transthoracic ultrasound
- Volunteers
- 1 people
- Sponsor
- Assiut University
Crimean-Congo Hemorrhagic Fever, Lassa Fever
Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities
This is a Phase 2 study of the safety and efficacy of Intravenous (IV) Ribavirin in treating patients presenting with a probable or suspected case of viral hemorrhagic fever (either Crimean Congo or Lassa Fever) at a military…
- Trial name
- NCT00992693
- Testing
- Ribavirin (Virazole) Injection
- Where
- Germany
- Sponsor
- U.S. Army Medical Research and Development Command
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Pneumonia, Ventilator-Associated
Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia
The objective of the study is to prove that after the third day of invasive mechanical ventilation a three-day course of inhaled amikacin reduces the incidence of subsequent VAP.
- Trial name
- AMIKINHAL (NCT03149640)
- Testing
- Inhaled amikacin
- Where
- 18 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Tours
Ventilator-associated Pneumonia
Impact of the Subglottic Secretions Drainage on the Tracheal Secretions Colonisation
Meta-analysis provide evidence for the benefit of the subglottic secretions drainage (SSD) to reduce the occurrence of Ventilator-Associated Pneumonia (VAP).
- Trial name
- NCT02583308
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 15 sites in Belgium, France
- Volunteers
- 896 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Nosocomial Infections
Potential Nosocomial Infection Prevention Via Modification of Anesthesia Intraoperative Aseptic Practice
We hypothesized that by improving hand hygiene compliance in the operative environment, we would reduce horizontal transmission of pathogenic bacteria to surgical patients.
- Trial name
- NCT00617006
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ventilator-Associated Pneumonia (VAP)
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
- Trial name
- NCT07203638
- Testing
- Beta Lactam Antibiotics, Salin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Esraa Salah Mohamed Abdallah Eladl
Intervention (Training) Condition
The Effect of Cognitive Behavioral Therapy
The aim of this study is to investigate the effect of hand hygiene training applied using cognitive behavioural therapy techniques on healthcare workers' attitudes and beliefs regarding nosocomial infections.
- Trial name
- AHIEVRAN (NCT07506915)
- Testing
- Hand hygiene training using cognitive behavioural therapy techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Ventilation Acquired Pneumonia
Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center
The goal of this clinical trial is to determine the most effective empirical therapy of antibiotics for better ventilator-associated pneumonia control.
- Trial name
- NCT06739382
- Testing
- extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin., two β-lactam antibiotics plus a single non-β-lactam antibiotic, Control group received standard therapy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Beni-Suef University
Nosocomial Infection in Neonatal Intensive Care Unit
Bacteriological Profile and Antibiotic Sensitivity in Neonatal Intensive Care Unit at Assuit University Children Hospital
The study aims to assess the bacteriological profile and antibiotic sensitivity in NICU of pediatric hospital of assuit university.
- Trial name
- NCT06891768
- Testing
- Blood culture
- Volunteers
- 134 people
- Sponsor
- Assiut University
Health Care Associated Infection
Care Bundle to Limit External Ventricular Drain Associated iNfections
The aim of our study is to reduce the incidence of External ventricular drain (EVD)-related infections by implementing a bundle of measures including updated care protocoles and training of residents, nurses and nurses…
- Trial name
- CLEAN-EVD (NCT07619625)
- Testing
- Bundle of measures including updated care protocoles and training of residents, nurses and nurses assistants
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ventilator Associated Pneumonia
Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia
The goal of this clinical trial is to learn if nebulized colistimethate sodium can prevent pneumonia in ventilated children. The main question it aims to answer is: Does nebulized colistimethate sodium lower the number of times…
- Trial name
- ColiPed (NCT06488794)
- Testing
- colistimethate sodium, 0.9% Saline
- Volunteers
- 400 people
- Sponsor
- University Hospital Fattouma Bourguiba
Bronchiolitis
Cohort Isolation and Cross-infection in Bronchiolitis
The purpose of this study is to investigate the effect of cohort isolation of RS(respiratory syncytial virus)-positive bronchiolitis versus RS-negative bronchiolitis on prevention of co-infection and clinical disease severity.
- Trial name
- NCT01441466
- Testing
- Isolation
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Princess Amalia Children's Clinic