Clinical trials: Healthcare-Associated Infections
Cross Infection
Impact of an On-site Simulation-based Training Programme on Adherence to Standard Precautions and Healthcare-associated Infections in Adult Intensive Care
This is a prospective, single-centre, quasi-experimental before-and-after study conducted over 18 months in an adult ICU. The study includes a 6-month pre-intervention period, a 6-month intervention period during which healthcare…
- Trial name
- SIMRéa (NCT07822971)
- Testing
- Simulation-based training programme, No intervention
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Nosocomial Pneumonia
International Study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE)
The International study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE) is a prospective, international, multicentre, observational, cohort study.
- Trial name
- PneumoINSPIRE (NCT02793141)
- Testing
- No intervention
- Where
- 2 sites in Australia, Greece
- Volunteers
- 1,657 people
- Sponsor
- The University of Queensland
Gram-negative Bacteria, Lipid Metabolism
Lipid Kinetics of Patients With Pneumonia
Nonfermenting Gram-Negative Bacilli (NFGNB) are aerobic, non-motile, non-lactose fermenting, oxidase-negative, catalase-positive coccobacilli that pose a serious threat to critically ill patients.
- Conditions
- Gram-negative Bacteria, Lipid Metabolism, Nosocomial Infections
- Trial name
- NCT04748432
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Konya Numune Hospital
Nosocomial Pneumonia, COPD Exacerbation
Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients
Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations.
- Trial name
- NCT06691399
- Testing
- Oral care
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Nosocomial Pneumonia, Community-acquired Pneumonia
High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia
This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study.
- Trial name
- NO PNEUMONIA (NCT06170372)
- Testing
- 200 ppm Nitric Oxide
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
Ventilator-associated pneumonia (VAP) is the most frequent infection occurring in patients who are admitted to the ICU. The accumulation of respiratory secretions in the subglottic space is a well-proven cause of VAP.
- Trial name
- NCT02632539
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Volunteers
- 220 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator Associated Pneumonia
Optimal Endotracheal Cuff Pressure During Hospitalization in Intensive Care Units Using AnapnoGuard 100 System
Hospitech Respiration Ltd has developed the AnapnoGuard system, an innovative system intended to enhance optimal endotracheal tube (ETT) cuff inflation, by monitoring carbon dioxide (CO2) in upper airways of mechanically…
- Trial name
- NCT01188122
- Testing
- AnapnoGuard 100
- Where
- Romania
- Volunteers
- 12 people
- Sponsor
- Hospitech Respiration
Mechanical Ventilation
Lung Microbiota and VAP Development (PULMIVAP)
Ventilator-associated pneumonia (VAP) refers to a lower respiratory tract nosocomial infection acquired >48h after being intubated in Intensive Care Units.
- Trial name
- PULMIVAP (NCT04849039)
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Hand, Health Care Associated Infection
Investigation of Fluorescent Concretization Intervention on Intensive Care Nurses' Hand Hygiene Training
Aim: The primary objective was to assess the effect of fluorescent concretization intervention on intensive care nurses' hand-washing efficiency, skill performance, and duration scores during the training process.
- Conditions
- Hand, Health Care Associated Infection, Training Group, Sensitivity
- Trial name
- NCT06572176
- Testing
- With fluorescent concretization group
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uludag University
Ventilator Associated Pneumonia
Usage of Meropenem/Gentamicin Versus Ceftazidime/Avibactam in ARDS
This was a prospective double blind study conducted on 200 polytrauma patients admitted to King Abdul-Aziz Specialized Hospital, Taif, KSA between July 2018 and December 2019 in surgical ICU.
- Trial name
- NCT04402359
- Testing
- meropenem, ceftazidime 2 grams and avibactam 500, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Aging, Frailty
Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)
This prospective multicenter study aims at exploring the impact of infections on intra-hospital and 3-month changes in the frailty profile of older inpatients.
- Conditions
- Aging, Frailty, Telomere Shortening, Inflammation
- Trial name
- INFRAGEN (NCT06430073)
- Volunteers
- 340 people
- Sponsor
- University Hospital of Ferrara
Pathogen Resistance, Pneumococcal Infection
Aerosolized and Intravenous Colistin in Healthy Adults
Colistin is amphipathic, cannot be absorbed from the gastrointestinal tract and is administered intramuscularly, intravenously (IV) or via inhalation.
- Conditions
- Pathogen Resistance, Pneumococcal Infection, Pneumonia
- Trial name
- NCT01863719
- Testing
- Colistimethate sodium
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventilator-associated Pneumonia, Sepsis
Diagnostic Value of Pulmonary Ultrasound in the Diagnosis of Ventilator-associated Pneumoniae
This study evaluates the respective values and combined CPIS (Clinical Pulmonary Infection Score), bronchoalveolar lavage (BAL), tracheal aspiration and pulmonary ultrasonography (LUS - Lung Ultrasound) for early diagnosis of…
- Trial name
- PAVM (NCT02536547)
- Testing
- VAP
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pneumonia
Microbiology and Clinical Outcome of Pneumonia
1. BACKGROUND Pneumonia occurring outside of the hospital setting is regarded as community acquired pneumonia. However, pneumonia occurring in non-hospital long-term care facilities constituted a distinct type of pneumonia from…
- Trial name
- NCT00873522
- Where
- Taiwan
- Volunteers
- 2,600 people
- Sponsor
- Taichung Veterans General Hospital
Nosocomial Infection
Biosafety of Musical Instruments in the ICU
This study investigates the efficacy of the institutional disinfection protocol for musical instruments in the ICU of the music therapy service of the University Hospital Fundación Santa Fe de Bogotá (FSFB), Colombia.
- Trial name
- NCT05988853
- Testing
- follow-up of patients
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Santa Fe de Bogota
Ventilator-Associated Pneumonia
Atropine for Preventing Ventilator-Associated Pneumonia
A double-blind, placebo controlled trial of atropine eye drops used by sublingual way for preventing Ventilator-Associated Pneumonia.
- Trial name
- NCT02704923
- Testing
- Atropine
- Volunteers
- 40 people
- Sponsor
- Universidade de Passo Fundo
Ventilator-Associated Pneumonia
Diagnostic Value of Lung Ultrasound for Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by mechanically-ventilated patients in the intensive care unit (ICU).
- Trial name
- VPLUS (NCT02244723)
- Testing
- Lung ultrasound examination
- Where
- 2 sites in France, Italy
- Volunteers
- 98 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Hand Hygiene Practices Among Nurses, Nursing Education
Effects of Virtual Reality Hand Hygiene Simulation on Nurses' Hand Hygiene
Healthcare-associated infections (HAIs) are an important patient safety concern, and hand hygiene is one of the most effective measures for preventing their transmission.
- Conditions
- Hand Hygiene Practices Among Nurses, Nursing Education, Simulation Training, Virtual Reality
- Trial name
- NCT06788405
- Testing
- Virtual Reality Hand Hygiene Simulation, Standard Hand Hygiene Training
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Askin Selvi