Clinical trials: Healthcare-Associated Infections
Critical Illness, Mechanical Ventilation
Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial
Ventilator-associated pneumonia (VAP) remains the most common hospital-acquired infection worldwide, affecting up to 40% of mechanically ventilated patients and contributing to increased morbidity, prolonged hospital stays, and…
- Trial name
- MICRO-VAP (NCT07463339)
- Testing
- Microbiome-guided inhaled antibiotic prophylaxis
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Nosocomial Infection
Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
Hospital acquired chest Infections are common complications in hospitalized cirrhotic patients. Infectious complications are the most common cause of mortality in cirrhotic patients with bronchopneumonia early antibiotic…
- Trial name
- NCT03413293
- Testing
- Diagnosis of bacterial infections
- Volunteers
- 20 people
- Sponsor
- Assiut University
Nosocomial Infection, Respiratory Tract Infection
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
- Conditions
- Nosocomial Infection, Respiratory Tract Infection, Surgical Site Infection
- Trial name
- NCT00272675
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hepatitis C, Hemodialysis
Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis C
This is a study to define strategies for Nephrologists to directly supervise and apply direct acting antivirals to cure hepatitis C in hemodialysis patients.
- Conditions
- Hepatitis C, Hemodialysis, Nosocomial Infection
- Trial name
- HD (NCT03365635)
- Testing
- Elbasvir 50 MG / Grazoprevir 100 MG [Zepatier]
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Nosocomial Infection
Evaluation of Body-worn Multimodal Hand Hygiene System. Impact on Health-Care Associated Infections
Evaluate the efficacy of a multimodal hand hygiene system in the intensive care unit environment and evaluate any impact on health care associated infections.
- Trial name
- Sprixx-ICU (NCT01050608)
- Testing
- Body worn alcohol gel dispenser, 62% ethanol based hand cleanser, Educational component with regard to teaching CDC guidelines
- Where
- United States
- Volunteers
- 2,954 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pneumonia, Critical Illness
Drug Resistance Factors In Healthcare-associated Pneumonia
Recently clinical guidelines categorize pneumonia in to three types: community, healthcare-associated, and hospital-acquired. Much of the existing research to describe the epidemiology of pneumonia in critically ill patients…
- Trial name
- DEFINE (NCT02736097)
- Where
- 30 sites in United States, Saudi Arabia
- Volunteers
- 679 people
- Sponsor
- Critical Care Pharmacotherapy Trials Network
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
Taurolidine Lock Solution
Survey of Practices Regarding the Use of Taurolidine Lock Solutions in Patients With Insertion of a Peripherally Inserted Central Catheter (PICC) in a Vascular Access Unit
The primary objective of this study is to describe current practices regarding the administration of taurolidine lock solutions in relation to medical prescriptions for patients who have undergone peripherally inserted central…
- Trial name
- TAURO-USE2 (NCT07259421)
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Infections, Hospital
Alcohol Hand Gel Use in Mbale Regional Referral Hospital: a Cost Effectiveness Evaluation
Ministry of Health through the National Medical Stores has supplied alcohol-based handgels to the different health facilities in Uganda for the health care providers to use during clinical care.
- Trial name
- WardGel (NCT02435719)
- Where
- Uganda
- Volunteers
- 3,626 people
- Sponsor
- Sanyu Africa Research Institute
Ventilator-associated Pneumonia
Prognosis and Virulence Determination of Capsule and Endotoxin During Klebsiella Spp. Ventilator-associated Pneumonias
Ventilator-associated pneumonia is the leading cause of nosocomial infection in the ICU. The pathogens responsible are multiple, but enterobacteria constitute a major source of pathogens involved.
- Trial name
- PROVIDENCE (NCT05450796)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Leeches, Healthcare Associated Infection
Risk Benefit Ratio of Hirudotherapy: Retrospective Single-center Study of 37 Cases Over a Period of 9 Years
Venous congestion in transplanted or re-implanted tissues remains a common and chal-lenging complication in plastic and reconstructive surgery.
- Trial name
- AMLEE (NCT04676581)
- Testing
- Leech Therapy
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hospital-Acquired Pneumonia
Efficacy and Safety of Ceftazidime-Avibactam (CAZ-AVI) in Chinese Participants With HAP (Including VAP)
This is a prospective, single arm, open-label, multi-center clinical study evaluating the effectiveness and safety of CAZ-AVI in participants with HAP (including VAP), who have initiated treatment with CAZ-AVI in an inpatient…
- Trial name
- NCT04774094
- Testing
- Zavicefta, Ceftazidime-Avibactam
- Where
- 56 sites in China
- Volunteers
- 235 people
- Sponsor
- Pfizer
Healthcare Associated Infections
Impact of Daily Bathing With Chlorhexidine in the Critical Patient
The search for preventive measure with daily bathing with chlorhexidine in the critical care patient will result in a reduction in patient colonization with multidrug resistant pathogens.
- Trial name
- NCT02870062
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Ventilator-Associated Pneumonia
Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols
Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections among mechanically ventilated patients and is associated with increased morbidity, mortality, length of intensive care unit stay…
- Trial name
- VAP-ML (NCT07866027)
- Testing
- Mobile-Based Microlearning Program, Routine Education
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Hospital-Acquired Bacterial Pneumonia, Ventilator-Associated Bacterial Pneumonia
A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia
The purpose of this study is to determine the efficacy, safety, tolerability, and pharmacokinetics (PK) of meropenem-vaborbactam compared to piperacillin/tazobactam for 7 to 14 days in the treatment of hospitalized adults who…
- Conditions
- Hospital-Acquired Bacterial Pneumonia, Ventilator-Associated Bacterial Pneumonia, Hospital-Acquired Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- TANGOIII (NCT03006679)
- Testing
- Meropenem-Vaborbactam, Piperacillin/Tazobactam
- Sponsor
- Melinta Therapeutics, Inc.
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Complication of Surgical Procedure
Hand Hygiene and Hospital Acquired Infections
Healthcare-associated infections (HCAIs) and evolving bacterial resistance are major public health concerns that impact all areas of healthcare.
- Trial name
- NCT02252562
- Testing
- Sage Personal Hand Hygiene System
- Where
- 2 sites in United States
- Volunteers
- 3,256 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
VAP - Ventilator Associated Pneumonia, Care
Effect of the Aspiration Care Bundle on Preventing VAP
Many pharmacological and non-pharmacological interventions are used to prevent ventilator-associated pneumonia (VAP). Nurses are directly responsible for implementing non-pharmacological interventions and therefore have an…
- Conditions
- VAP - Ventilator Associated Pneumonia, Care, Bundle Care, Aspiration
- Trial name
- NCT07138651
- Testing
- Aspiration care bundle
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Pneumonia, Bronchopneumonia
Duration of Antibiotic Therapy in Community - Acquired Pneumonia
The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject's clinical response compared to a local standard approach in patients coming from the…
- Conditions
- Pneumonia, Bronchopneumonia, Pleuropneumonia, Pneumonia, Bacterial
- Trial name
- DURATION (NCT01492387)
- Testing
- Discontinuation of antibiotic therapy
- Where
- 15 sites in Italy
- Volunteers
- 892 people
- Sponsor
- University of Milan
Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection
Effect of Use of Probiotics on Systemic Infection in Critically Ill Patients: a Double Blind, Randomized, Placebo-controlled Trial
The primary goal of this study is to assess the benefit of probiotics in preventing or minimizing of various type of systemic infection in critically ill adult patients.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection, Urinary Tract Infection, Diarrhea
- Trial name
- NCT07164781
- Testing
- Bacillus clausii, Sugar tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University