Clinical trials: Healthcare-Associated Infections
Respiratory Tract Diseases, Nosocomial Infections
Impact of Antibiotic Treatment on Outcome in Patients With Ventilator-Associated Tracheobronchitis
The aim of this study is to determine whether antibiotic treatment could reduce mechanical ventilation duration in patients with nosocomial tracheobronchitis acquired under mechanical ventilation.
- Trial name
- NCT00122057
- Testing
- antibiotic treatment
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Lille
Ventilator Associated Pneumonia
Open Label Pharmacokinetic in Adult Patients With Ventilator-Associated Pneumonia
The purpose of this research study is to measure the levels of ceftobiprole in the blood, urine and tissues of the lungs during and after administration of four doses of ceftobiprole. Safety of the drug will also be evaluated.
- Trial name
- NCT00771719
- Testing
- Ceftobiprole
- Volunteers
- 1 people
- Sponsor
- Basilea Pharmaceutica
Patient Care Bundles, Interdisciplinary Communication
Application Effect Analysis of Bundle Nursing Intervention
This study aims to evaluate the impact of a multidisciplinary collaborative bundle nursing intervention based on targeted surveillance on the incidence of ICU device-associated infections (DAIs).
- Conditions
- Patient Care Bundles, Interdisciplinary Communication, Intensive Care Units (ICUs), Equipment and Supplies
- Trial name
- NCT07656363
- Testing
- routine ICU nursing, HAI prevention, prevention and control collaboration
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Qinhuangdao
Hospital Infection, Urinary Tract Infections
The Global Prevalence of Infections in Urology Study
Urology departments from all over the world are invited to join the Global Prevalence Study on Infections in Urology (GPIU-study) and the GPIU Prostate Biopsy Side Study.
- Trial name
- GPIU (NCT03665467)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 2,000 people
- Sponsor
- European Association of Urology Research Foundation
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPB
The primary aim of this single-center, prospective, randomized, controlled, pilot study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac…
- Trial name
- NCT06162455
- Testing
- 200- ppm NO
- Where
- Russia
- Volunteers
- 74 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Preservation of Gut Mucosa Integrity in Patients Requiring Mechanical Ventilation and Catecholamine
To demonstrate that a strategy involving early first-line enteral nutrition is associated with improved preservation of gut mucosa integrity, as assessed based on the plasma citrulline level at H72, compared to a strategy…
- Trial name
- NCT03852940
- Testing
- Parenteral nutrition, Enteral Nutrition
- Where
- 6 sites in France
- Volunteers
- 169 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pneumonia, Ventilator Associated Pneumonia
Safety and Pharmacokinetics of KBPA-101 in Hospital Acquired Pneumonia Caused by O11 Pseudomonas Aeruginosa
The objectives of this open study are to assess the safety, tolerability, pharmacokinetics and clinical outcome of patients who have HAP caused by Pseudomonas aeruginosa serotype O11 after three separate administrations of…
- Trial name
- NCT00851435
- Testing
- KBPA-101
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Kenta Biotech Ltd
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Community-acquired Pneumonia
Failure and Cardiovascular Events in Community-acquired Pneumonia
Although failure and mortality are the most relevant outcomes in patients with Community-acquired Pneumonia (CAP), there is little discussion in the literature on their incidence and etiology.
- Trial name
- FAILCAP (NCT01143155)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- University of Milan
Ventricular Drain Related Infection, Nosocomial Infection
Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections
External ventricular drain infections are difficult to identify with current diagnostic methods. Initiation of antibiotic treatment is usually supported by indirect methods of bacterial infection, such as clinical signs or…
- Conditions
- Ventricular Drain Related Infection, Nosocomial Infection, Infection, Bacterial, Ventriculitis, Infectious
- Trial name
- EVD Infect II (NCT05904535)
- Testing
- Cerbrospinal fluid sampling.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Hospital Infection
Application of Standardized Cleaning and Disinfection Mode of HFT Surface in Hospital Infection Prevention and Control
The scientific, feasible and effective mode of standardized cleaning and disinfection of ICU high-frequency contact surfaces is discussed and verified.
- Trial name
- NCT04920240
- Testing
- cleaning and disinfection mode for surfaces with high frequency contact, Routine procedure
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pneumonia, Bacterial, Nosocomial Infection
A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections
The purpose of this study is to assess the safety and effectiveness of doripenem treatment among Filipino patients with nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infection.
- Conditions
- Pneumonia, Bacterial, Nosocomial Infection, Intraabdominal Infections, Urinary Tract Infection
- Trial name
- NCT01763008
- Testing
- No intervention
- Where
- 4 sites in Philippines
- Volunteers
- 170 people
- Sponsor
- Janssen Pharmaceutica
Pneumonia, Ventilator-Associated, Stenotrophomonas Infection
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs
Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or…
- Conditions
- Pneumonia, Ventilator-Associated, Stenotrophomonas Infection, Critical Illness, Pneumonia, Bacterial
- Trial name
- RETROSTENO (NCT03506191)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Aspiration of Subglottic Secretions
Aspiration of Subglottic Secretions Using Hi-Lo Evac Endotracheal Tube: Tube Size and Incidence of Suction Lumen Dysfunction
To evaluate the correlation between endotracheal tube size and incidence of dysfunction of suction lumen of Hi-Lo Evac endotracheal tube in critically ill patients who required mechanical ventilation for more than 48 hours.
- Trial name
- NCT00450476
- Testing
- Hi-Lo Evac Endotracheal Tube
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University Hospital, Alexandroupolis
Pneumonia
M-ROSE Combined With mNGS in Severe Hospital-acquired Pneumonia
The purpose of this study is to determine the value of M-ROSE（microbiological rapid on-site evaluation）in severe hospital-acquired pneumonia.
- Trial name
- NCT05300776
- Testing
- M-ROSE analysis
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Chinese PLA General Hospital
Ventilator Associated Pneumonia
Diagnostic Stewardship for Ventilator Associated Pneumonia
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for patients who have respiratory…
- Trial name
- NCT05989269
- Testing
- Modified lab reporting
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- University of Maryland, Baltimore
Respiration, Artificial, COVID-19
Healthcare-associated Infections in Severe COVID-19 During 2020
In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2.
- Conditions
- Respiration, Artificial, COVID-19, Health Care Associated Infection
- Trial name
- COVIACS (NCT04819165)
- Testing
- COVID-19
- Where
- Argentina
- Volunteers
- 252 people
- Sponsor
- Sanatorio Anchorena San Martin
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
Multidrug Resistance
Point Prevalence Study of Multidrug-Resistant Organism Carriage by Healthcare Personnel
Acquisition and transmission of MDROs in healthcare facilities is a major patient safety problem, afflicting in particular the antibiotic-exposed and immunodeficient patient populations.
- Trial name
- NCT01952158
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthcare Associated Infection, Critically Ill
Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, with a significant proportion related to central venous catheters, and an influence on both morbility and mortality.
- Conditions
- Healthcare Associated Infection, Critically Ill, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- OCT-BIO-CVC (NCT06216080)
- Testing
- D-FF-OCT analysis of CVC
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône