Clinical trials: Healthcare-Associated Infections
Cross Infection
Randomized Pilot Study Evaluating Isopropyl Alcohol and UVC Rays in Disinfection of Cell Phones
Cell phones have become a fundamental accessory of our lives and clinical practice, often kept in contact with the body. Since most modern smartphones are equipped with touch screens, they can serve the function of reservoirs for…
- Trial name
- SaniPhone (NCT06194903)
- Testing
- isopropyl alcohol wipes, UVC box
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Methicillin-resistant Staphylococcus Aureus, Pneumonia, Ventilator-Associated
Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia
As previous studies showed that the synergy between linezolid and carbapenem in vitro and in vivo (animal studies), our study is aim to investigate the activity of linezolid, alone and in combination with carbapenem against…
- Trial name
- NCT01356472
- Testing
- Imipenem/cilastatin
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Neonatal Sepsis
Chlorhexidine Gluconate and Alcohol Hand Rubbing on Healthcare-associated Infection
This study aims to compare of effect of chlorhexidine gluconate and alcohol hand rubbing on healthcare-associated infection (HCAI) in neonatal intensive care unit at Alexandria University Children Hospital.
- Trial name
- NCT07421323
- Testing
- Alcohol hand rub group, Chlorhexidine hand rub
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Ventilator Associated Pneumonia
Treatment of Ventilator Associated Pneumonia in Pediatric Intensive Care Unit
treatment of ventilator associated pneumonia in pediatric intensive care unit according to the American guidelines
- Trial name
- NCT03294837
- Volunteers
- 40 people
- Sponsor
- Assiut University
Critical Illness
Impact of Gender on Hospitalized Patients
The purpose of this study is to better understand the relationship between gender (being a man or a woman), infections caught in the hospital, and serious illness.
- Trial name
- NCT00843557
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Virginia
Nutrition Disorders
Comparison of Continuous Versus Intermittent Enteral Nutrition in Critically Ill Patients.
The purpose of the study is to compare continuous versus intermittent strategy for enteral nutrition. The study will examine if there is a difference in achieving nutritional delivery goals, tolerance and number of complications…
- Trial name
- COINN (NCT03573453)
- Testing
- enteral nutrition
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Masaryk University
Contaminated Medical or Biological Substances, Environmental-Pollution-Related Condition
Potential Risk for Bacterial Contamination in Ventilator Systems
Background: Few studies have investigated the difference of bacterial contamination between conventional reused ventilator systems and disposable closed ventilator-suction systems.
- Trial name
- NCT03359148
- Testing
- Disposable ventilator system, Conventional reused ventilator system
- Volunteers
- 27 people
- Sponsor
- Chang Gung University
Hypoxemia, Arrhythmias
Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning
Morbidity frequency associated to a endotracheal suctioning is different between a necessity endotracheal suctioning protocol versus a routine endotracheal protocol.
- Conditions
- Hypoxemia, Arrhythmias, Cardiac Arrest, Ventilator Associated Pneumonia
- Trial name
- NCT01069185
- Testing
- Necessity endotracheal suctioning, Routine endotracheal suctioning
- Where
- Colombia
- Volunteers
- 92 people
- Sponsor
- Hospital Pablo Tobón Uribe
Microbial Colonization, COVID-19 Respiratory Infection
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
The aims of this study were: 1. Observation of dynamics in oral microbiota and its association with the incidence of HAIs and VAP in mechanically ventilated COVID-19 patients in an ICU setting 2.
- Conditions
- Microbial Colonization, COVID-19 Respiratory Infection, Dysbiosis, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT05575050
- Testing
- Oral Procedure
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- University Hospital in Krakow
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Postoperative Complications, Surgical Site Infection
Hierarchy of Effects of Laboratory Markers and Their Interaction With Comorbidity Concerning Outcome and Personalized Treatment of Trauma Patients in Emergency Care and Rehabilitation
At least ten percent of trauma patients suffer from any sort of complication. The study aims to identify a risk factor profile to early identify trauma patients at risk.
- Conditions
- Postoperative Complications, Surgical Site Infection, Wound Infection, Non-healing Wound
- Trial name
- HELICOPTER (NCT06758427)
- Where
- Germany
- Volunteers
- 2,300 people
- Sponsor
- Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu
Health Care Associated Infection, Catheter-associated Urinary Tract Infection
Clinical Decision Support to Reduce Catheter Associated Urinary Tract Infections
The goal of this randomized controlled trial is to compare the effects of a clinical decision support tool consisting of a 48-hour stop order for indwelling urinary catheters versus no clinical decision support in hospitalized…
- Trial name
- NCT06454500
- Testing
- Clinical decision support
- Where
- 8 sites in United States
- Volunteers
- 79,369 people, healthy volunteers welcome
- Sponsor
- Columbia University
Ventilator Associated Pneumonia
Biomarkers in Patients Undergoing Mechanical Ventilation
To evaluate in a cohort of patients on mechanical ventilation, for non-infectious reasons and for documented sepsis of pulmonary as well as non-pulmonary origin, the bacterial load, procalcitonine (PCT), C-Reactive Protein (CRP)…
- Trial name
- VAP (NCT02078999)
- Where
- Spain
- Volunteers
- 211 people
- Sponsor
- Corporacion Parc Tauli
Pneumonia, Pneumonia, Ventilator-Associated
Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia
Hypoxemic pneumonia is a major cause of hospitalization in Pulmonology. The patient's dependency on oxygen prevents early discharge from the hospital.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Length of Stay
- Trial name
- OPPAÎ (NCT03527992)
- Testing
- O2 automated, O2 standard
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Toulouse
Surgical Wound Infection, Cross Infection
Reducing Intraoperative ESKAPE Transmission Through Use of a Personal Hand Hygiene System
The investigators hypothesize that the use of a personal hand hygiene system (SafeHavenTM) by anesthesia providers in the adult operating room, combined with a novel infectious pathogen tracking system (OR PathTrac) will decrease…
- Trial name
- ESKAPE (NCT04900298)
- Testing
- SafeHaven Automated Hand Hygiene Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Nosocomial Pneumonia
Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)
This is a phase 1, open-label, non-comparative, multicenter clinical study to evaluate the safety, tolerability, and pharmacokinetics of ceftolozane/tazobactam (MK-7625A) in pediatric participants with nosocomial pneumonia (NP).
- Trial name
- NCT04223752
- Testing
- Ceftolozane/Tazobactam
- Where
- 24 sites in United States, Chile and 7 more
- Volunteers
- 41 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiac Surgical Procedures (Postoperative Population), Critical Illness
BIS in ICU Interventional Study
This study will test whether using a Bispectral Index (BIS) monitor to guide sedation can reduce the amount of sedative medication given to adults in the intensive care unit (ICU) after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures (Postoperative Population), Critical Illness, Postoperative Complications (Cardiopulmonary), Delirium - Postoperative
- Trial name
- NCT07350122
- Testing
- Device-guided sedation, standard sedation practice
- Volunteers
- 144 people
- Sponsor
- Medical University of Graz
Coronary Artery Disease, Pneumonia Nosocomial
Nosocomial Pneumonia After Coronary Artery Bypass Grafting
Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery.
- Trial name
- CABG-PNEUM (NCT07476274)
- Testing
- Clinical, laboratory, and instrumental examination
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ventilator-Associated Pneumonia (VAP)
Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia
This is a Phase 3, multicenter, prospective, randomized, open-label, study to compare the safety and efficacy of intravenous (IV) ceftolozane/tazobactam with that of IV piperacillin/tazobactam in the treatment of…
- Trial name
- NCT01853982
- Testing
- Ceftolozane/Tazobactam, Piperacillin/Tazobactam
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 4 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Polymyxin B, Ventilator-associated Pneumonia
Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients
The goal of this observational study is to investigate whether intravenous polymyxin B combined with nebulisation achieves better antimicrobial efficacy and clinical outcomes than intravenous use alone in patients with…
- Conditions
- Polymyxin B, Ventilator-associated Pneumonia, Multidrug Resistant Bacterial Infection, Pharmacogenomic Drug Interaction
- Trial name
- NCT06076603
- Testing
- nebulized polymyxin B
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Southeast University, China