Clinical trials: Healthcare-Associated Infections
Ventilator Associated Pneumonia (VAP)
Heparin Binding Protein Versus Platelet Count and Mean Platelet Volume Kinetics in the Diagnosis and Prognosis of VAP
mechanically ventilated for 48 hours or more and subsequently develop ventilator-associated pneumonia (VAP). After obtaining approval from the local ethical committee at the Faculty of Medicine, El-Minia University, and informed…
- Trial name
- NCT06993623
- Testing
- heparin binding protien
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Esraa Hamdy Thabit Riad
Hospital Acquired Infection
Transmission of ESBL-producing Enterobacteriaceae
The aim of this research project is to investigate the transmission of ESBL-producing Enterobacteriaceae on both, the level of bacterial strains and mobile genetic elements, and to determine the source of hospital-acquired…
- Trial name
- NCT03465683
- Testing
- ESBL-producing Enterobacteriaceae
- Where
- Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Enteral Feeding, Ventilator-Associated Pneumonia
Impact of Intermittent and Continuous Enteral Feeding on Ventilator-associated Pneumonia in Pediatric ICUs
Mechanical ventilation has become one of the most important supportive treatment methods to save the life of critically ill children over time.
- Trial name
- NCT02973347
- Testing
- Intermittent enteral feeding, Continuous enteral feeding
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Occupational Exposure to Blood, Healthcare-associated Related Infections
Stress at Work and Infectious Risk in Patients and Caregivers
In hospitals, the improvement of working conditions is often considered secondarily to patient satisfaction. Previous studies, showing statistically significant relationships, suggested the impact of hospital departments'…
- Conditions
- Occupational Exposure to Blood, Healthcare-associated Related Infections, Stress, Fatigue
- Trial name
- STRIPPS (NCT03532321)
- Testing
- NA : non interventional study
- Where
- France
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pseudomonas Aeruginosa, Ventilator Associated Pneumonia
Pilot Trial of KB001 in Mechanically-Ventilated Patients Colonized With Pseudomonas Aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes disease in healthy people, but is a significant problem for critically ill or immunocompromised individuals.
- Trial name
- NCT00691587
- Testing
- KB001
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Humanigen, Inc.
Respiratory Tract Infection Bacterial
Epidemiology of Hospital Acquired Pneumonia
This project aimed at analyzing and assessing of the early and late Hospital-Acquired Pneumonia(HAP) bacterial pathogens and their resistance to antimicrobial agents.
- Trial name
- HAP (NCT02614144)
- Volunteers
- 214 people
- Sponsor
- University Hospital Olomouc
Methicillin-Resistant Staphylococcus Aureus (MRSA), Hospital-Acquired Pneumonia
Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin
The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference…
- Trial name
- NCT01561469
- Testing
- Linezolid, Vancomycin
- Volunteers
- 188 people
- Sponsor
- Pfizer
Ventilator-associated Pneumonia
Subglottic Secretions Surveillance to Predict Bacterial Pathogens Involved in Ventilator-associated Pneumonia
Many studies provide evidence for the benefit of lower respiratory tract surveillance, mostly by culture of endotracheal secretions, to predict bacterial pathogens (especially multi-drugs resistant pathogens) involved in VAP.
- Trial name
- NCT02585180
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 15 sites in Belgium, France
- Volunteers
- 420 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Ventilator Associated Pneumonia
Oro-nasal Decontamination to Prevent Ventilator-associated Pneumonia
It has been shown that oral hygiene reduces the incidence of ventilator-associated pneumonia (VAP). The nasopharynx is considered to be an important source of contaminated micro aspiration to the lung however, the effect of…
- Trial name
- NCT05895773
- Testing
- Povidone-Iodine, Saline spray
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Menoufia University
Pressure Ulcer
Comparative Assessment of Effectiveness and Safety of Methods for Skin and Hair Care in Severe Intensive Care Unit Patients
Skin care for seriously ill patients in the intensive care unit (ICU) is one of the key components in the prevention of serious complications that affect the treatment outcome.
- Trial name
- NCT05112068
- Testing
- traditional skin care method, method using specialized gloves
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Pneumonia, Ventilator-Associated
Effect of Gravity on Tracheal Colonization During Mechanical Ventilation in Infants
Ventilator-associated pneumonia (VAP) is the leading cause of death among all nosocomial infections in ventilated patients. Once intubated, the risk of pneumonia in hospitalized patients is increased 3-10 fold; almost 90% of…
- Trial name
- NCT00491660
- Testing
- supine positioning, lateral positioning
- Volunteers
- 60 people
- Sponsor
- Cairo University
Ventilator Associated Pneumonia, Antibiotic Resistant Infection
Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.
The aim of this study is to report our experience with ceftolozane-tazobactam and to evaluate its safety and efficacy in the treatment of ICU dependent nosocomial respiratory tract infections due to extensively drug resistant…
- Trial name
- NCT04352855
- Testing
- Ceftolozane/tazobactam
- Where
- Hungary
- Volunteers
- 55 people
- Sponsor
- Semmelweis University
Pneumonia, Ventilator-associated
Early Detection of Ventilator-associated Pneumonia (VAP)
The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation.
- Trial name
- cheqVAP (NCT02753608)
- Testing
- Collection of exhaled breath condensate
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Ventilator Associated Pneumonia ( VAP)
VAP Identification by AI
Ventilator-associated pneumonia (VAP) is the most frequent infection in the intensive care setting. For VAP there is currently no reliable diagnostic criteria.
- Trial name
- AI-VAP (NCT06917521)
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Children, Only, Educational Problems
Toy Hygiene Education For Hospitalized Mothers
The present study aims to evaluate the effectiveness of toy hygiene education given to mothers of hospitalized children on their knowledge and practices, as well as the cleanliness of toy surfaces.
- Conditions
- Children, Only, Educational Problems, Hospital Infection
- Trial name
- NCT06199804
- Testing
- Toy Hygiene Training
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sibel Küçükoğlu
Nosocomial Infection
Lactulose for the Prevention of Nosocomial Infections in Children
The purpose of this study is to assess the ability of lactulose, a prebiotic agent, to prevent hospital acquired infection in children
- Trial name
- NCT00273949
- Testing
- lactulose
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Guide Rapid Antibiotic Treatment for Serious Infections
This research will test a new ultra-rapid technology (called ID/AST Accelerate system) that uses a digital microscope to identify bacteria based on their growth patterns.
- Conditions
- INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- NCT02796716
- Testing
- Testing on new technology called Accelerate ID/AST system
- Where
- United States
- Volunteers
- 2,102 people
- Sponsor
- Denver Health and Hospital Authority
Ventilator Associated Pneumonia
The Duration of Antibiotic Therapy for Early (DATE) Ventilator Associated Pneumonia (VAP): 4 vs. 7 Days
The purpose of this study is to see if the amount of antibiotics given for ventilator-associated pneumonia (VAP) can be decreased in order to reduce the risk of adverse effects associated with antibiotics, while at the same time…
- Trial name
- DATE (NCT05545735)
- Testing
- Standard of Care Antibiotic Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Macrophage Programing in Acute Lung Injury: MiniBAL
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05767671
- Testing
- Non-Bronchoscopic Mini Bronchoalveolar Lavage
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- William Janssen, MD
Ventilator-Associated Pneumonia, Nosocomial Pneumonia
Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization…
- Conditions
- Ventilator-Associated Pneumonia, Nosocomial Pneumonia, Pneumonia
- Trial name
- RASPALL (NCT00842478)
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.