Clinical trials: Healthcare-Associated Infections
Ventilator-associated Pneumonia
Prevention Ventilator Associated Pneumonia
The objective of the investigators work was to evaluate the impact of 4 sequentially implemented measures for preventing VAP in a major heart surgery ICU.
- Trial name
- REINA (NCT02060045)
- Testing
- Bundle implementation
- Where
- Spain
- Volunteers
- 1,534 people
- Sponsor
- Maria Jesus Perez
Critically Ill
Directed Immuno Nutrition by L-arginine for Critically Ill Patients
The main objective of this proof-of-concept study is to demonstrate that the only administration of L-arginine, based on a suspected deficit monitored by nasal nitric oxide measurement, can improve immune functions in critically…
- Trial name
- Immunolarg (NCT01038622)
- Testing
- L-arginine
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Health Care Associated Infection
Water Hygiene Versus Waterless Hygiene Technology for Totally Dependent Hospitalized Patients
The aim of this randomized controlled trial is to verify whether the efficacy of perineal hygiene procedures performed in dependent patients admitted to medical or geriatric wards with pre-moistened wipes without water is higher…
- Trial name
- IGIENE-FAST (NCT06514131)
- Testing
- Pre-moistened wipes
- Where
- 4 sites in Italy
- Volunteers
- 468 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Covid19, Surgery--Complications
Impact of the COVID-19 Pandemic on the Surgical Activity of Bellvitge University Hospital
COVID-19 has been a challenge for hospitals; there was an obvious need to reconvert many spaces in specific areas to attend this pathology, without forgetting the attention to other pathologies and surgery.
- Conditions
- Covid19, Surgery--Complications, Nosocomial Infection
- Trial name
- NCT04780594
- Testing
- The study evaluates all surgical patients operated, both elective scheduled and emergent cases
- Where
- Spain
- Volunteers
- 2,530 people
- Sponsor
- Hospital Universitari de Bellvitge
Pneumonia
Trial of Iseganan in Prevention of Ventilator-Associated Pneumonia
This is a multinational, double-blind, placebo-controlled trial designed to assess whether iseganan, applied topically to the oral cavity, can prevent ventilator-associated pneumonia among patients who are intubated and…
- Trial name
- NCT00118781
- Testing
- iseganan hydrochloride
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- IntraBiotics Pharmaceuticals
Ventilator Associated Pneumonia
Effect of Educational Program About Preventive Care Bundle for Prevention of Ventilator Associated Pneumonia Among Newborns
This study is designed to investigate the effect of educational program for nurses about preventive care bundle for prevention of ventilator associated pneumonia among newborns.
- Trial name
- NCT06066489
- Testing
- educational program about VAP
- Volunteers
- 137 people
- Sponsor
- Damanhour University
Infection, Cross Infection
A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections
The purpose of this study is to assess the safety and efficacy of doripenem in participants with nosocomial pneumonia (inflammation of the lungs in which the lungs become heavy; pneumonia occurring at least 48 hours after…
- Conditions
- Infection, Cross Infection, Bacterial Infections, Pneumonia, Ventilator-Associated
- Trial name
- NCT00965848
- Testing
- Doripenem
- Where
- 8 sites in Thailand
- Volunteers
- 270 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Oral Infection, Ventilator-associated Pneumonia
Evaluating the Effectiveness of the Tongue Cleaner in Critical Patients
The concern with oral infection and its systemic repercussions is old, many studies have been undertaken to establish this relationship more precisely.
- Trial name
- NCT01294943
- Testing
- Tongue cleaner
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Ventilator-associated Pneumonia
VITAL - VAP Prevention by BIP (Bactiguard Infection Protection) ETT Evac in Belgian ICUs
The study objective is to determine VAP (Ventilator Associated Pneumonia) baseline incidence in the ICU in patients receiving endotracheal tubes with evacuation lumen with and without Bactiguard coating.
- Trial name
- VITAL (NCT04242706)
- Testing
- ETTEvac, BIP ETTEvac
- Where
- 2 sites in Belgium
- Volunteers
- 323 people
- Sponsor
- Bactiguard AB
Cross Infection, Pneumonia, Ventilator-associated
Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
This prospective, randomized, controlled trial will compare the incidence of nosocomial infections (composite of primary bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and…
- Conditions
- Cross Infection, Pneumonia, Ventilator-associated, Catheter-related Infections, Infection Due to Indwelling Urinary Catheter
- Trial name
- NCT01640925
- Testing
- Chlorhexidine gluconate, Standard bathing
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Joshua Swan
Ventilator Associated Pneumonia, Prevention
Nebulized Aztreonam for Prevention of Gram Negative Ventilator-associated Pneumonia
Aerosol antibiotic administration offers the theoretical advantages of achieving high drug concentration at the infection site and low systemic absorption, thereby avoiding toxicity.
- Conditions
- Ventilator Associated Pneumonia, Prevention, Respiratory Infection Other
- Trial name
- AZLIS (NCT03749226)
- Testing
- Aztreonam lysine, Aerogen Solo, CombiHaler
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Standard Precautions, Hand Hygiene Behavior
Infection Control Link Nurses Program to Improve Compliance With Standard Precautions, Hand Hygiene, and Prevent Healthcare-Associated Infections
The goal of this clinical trial is to learn if Infection Control Link Nurses (i.e., clinical nurses providing direct patient care with an interest and expertise in infection control practices) are effective in improving nurses'…
- Conditions
- Standard Precautions, Hand Hygiene Behavior, Healthcare Associated Infections
- Trial name
- INFECTION (NCT06857825)
- Testing
- Implementation of Infection Control Link Nurses (ICLNs)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
SIRS
Infections Related Central Venous Catheters
The purpose of this study is to clarify the relationship between SIRS (Systemic inflammatory response syndrome) and the infection associated with the use of central venous catheters at Critical Care center in National Defense…
- Trial name
- CVL (NCT00554021)
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- National Defense Medical College, Japan
Pneumonia Ventilator Associated, Pneumonia Neonatal
Reduction of the Incidence of NAV in Neonatal Units (INBERNAV-Neo)
The aim of this project is to achieve useful, universal and standardized definitions for the diagnosis and prevention of ventilator-associated neumonia in patients in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Pneumonia Ventilator Associated, Pneumonia Neonatal, Healthcare-associated Infections
- Trial name
- INBERNAV-Neo (NCT07240038)
- Testing
- Multimodal intervention to reduce the incidence of ventilator-associated pneumonia by training the health care team in specific and general evidence-based good clinical practices., Technique with a blind-protected catheter
- Where
- 39 sites in Spain
- Volunteers
- 1,500 people
- Sponsor
- Biobizkaia Health Research Institute
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Cystic Fibrosis, Nontuberculous Mycobacterium Infection
Healthcare-associated Links in Transmission of Nontuberculous Mycobacteria in Cystic Fibrosis
Sources of NTM infection and modes of transmission among CF patients are poorly understood. Healthcare-associated transmission of NTM among CF patients has been suspected and is of growing concern for CF Centers.
- Trial name
- HALTNTM (NCT04024423)
- Testing
- Epidemiologic investigation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Jewish Health
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Central Line Associated Blood Stream Infections (CLABSI)
Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction
Prospective, multi-center, cluster-randomized trial of a hospital Infection Preventionist (IP)-led quality improvement study to provide clinical teams with just-in-time clinical education and reinforcement of existing best…
- Trial name
- CLABSI AI (NCT07108660)
- Testing
- Infection Preventionist Led Best Practices Reminders
- Where
- 19 sites in United States
- Volunteers
- 17,800 people
- Sponsor
- Swedish Medical Center
Ventilator-Associated Pneumonia
Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates
comparing the effect of oral care with colostrum, chlorohexidine and sodium bicarbonate in prevention of ventilator-associated pneumonia in preterm neonates.
- Trial name
- NCT07482007
- Testing
- Oropharyngeal Care with Colostrum, Chlorhexidine Oral Care, Sodium Bicarbonate oral care
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Ventilator-acquired Pneumonia
Endotracheal Tubes for Prevention of Ventilator-associated Pneumonia
Researchers are looking at three different types of breathing tubes to see if any of them are better at preventing pneumonia than the others.
- Trial name
- PreVent (NCT01744483)
- Testing
- PVC ETT, PUC ETT, PUC-CASS ETT
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington