Clinical trials: Healthcare-Associated Infections
Ventilator-associated Pneumonia, Traumatic Brain Injury
Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury
This randomized controlled trial will compare closed versus open endotracheal suctioning techniques for preventing ventilator-associated pneumonia (VAP) in adults with severe traumatic brain injury (TBI) who need mechanical…
- Trial name
- NCT07883083
- Testing
- Closed endotracheal suction system, Open endotracheal suction
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Covid19, Nosocomial Infection
Treatment of Nosocomial COVID-19
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. Nosocomial acquisition of SARS-CoV-2 is a frequent concern across hospital settings in Canada and is…
- Conditions
- Covid19, Nosocomial Infection, SARS-CoV2 Infection
- Trial name
- CATCO-NOS (NCT04748588)
- Testing
- Anti-SARS-CoV-2 mAb
- Where
- 4 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Ventilator-Associated Pneumonia, Ventilator-Associated Tracheobronchitis
Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated Tracheobronchitis
The primary objective of the AMIVAT trial is to assess whether a 5-day course of inhaled amikacin, compared to placebo, reduces the incidence of progression to ventilator-associated pneumonia (VAP) at day 28 in intensive care…
- Trial name
- AMIVAT (NCT07665788)
- Testing
- Optimized and protocolized nebulization procedure.
- Where
- 17 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Tours
Nosocomial Infection
An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice
The present study is a retrospective cohort study on patients who suffered a nosocomial infection in major hospitals in Vietnam.
- Trial name
- NCT00864929
- Where
- 2 sites in Vietnam
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
COVID-19
COVID-19 Infection in Healthcare Workers
Introduction: The SARS-Cov-2 outbreak in France and the concomitant massive increase in the number of cases requiring hospital management create a major risk of COVID-19 infection for hospital staff.
- Trial name
- HOP-COVID (NCT04386759)
- Testing
- Cohort
- Where
- France
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SARS-CoV 2, Hospitalisation-Associated Infection
Protein Electrophoresis as a Tool for Complications Prediction in COVID-19 Hospitalised Patients
The inflammation is central in COVID-19 infections. Our aim is to evaluate the clinical value of measuring inflammation by using serum protein electrophoresis (SPE).
- Trial name
- COVELEC (NCT04414059)
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Elsan
Antibiotic-Associated Diarrhea, Clostridium Difficile-Associated Diarrhea
Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection
The purpose of this study is to evaluate the efficacy and safety of Bio-K+ CL-1285 in the prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridum difficile-Associated Diarrhea (CDAD) in hospitalized patients exposed to…
- Trial name
- NCT00958308
- Testing
- BIO-K+ CL-1285®
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Bio-K Plus International Inc.
Ventilator Associated Pneumonia
Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality .
- Trial name
- NCT04563104
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Ain Shams University
Ventilator Associated Pneumonia, Infection
Probiotic Prophylaxis for Microbiome Modulation and VAP or Infections Prevention in Multitrauma Patients
Ventilator-associated pneumonia (VAP), is a type of pneumonia that develops more than 48 hours after endotracheal intubation, is common in intensive care units (ICUs).
- Conditions
- Ventilator Associated Pneumonia, Infection, Trauma
- Trial name
- NCT03074552
- Testing
- LactoLevure
- Where
- Greece
- Volunteers
- 112 people
- Sponsor
- Aristotle University Of Thessaloniki
Community Acquired Pneumonia
A Retrospective Study on Hospitalized Patients With Community-acquired Pneumonia in China (CAP-China)
The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and healthcare-associated pneumonia (HCAP) in real life of China .
- Trial name
- RSCAP-China (NCT02489578)
- Testing
- other
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Capital Medical University
Hospital Infection, Multi-antibiotic Resistance
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.
Colistin is an antibiotic active against several classes of multi-resistant gram-negative bacteria; the drug should be used in high doses in patients on continuous renal replacement therapy, since the drug is eliminated through…
- Conditions
- Hospital Infection, Multi-antibiotic Resistance, Critically Ill
- Trial name
- NCT04995133
- Testing
- Colistin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Nosocomial Pneumonia
Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial Pneumonia
1. To observe clinical and bacteriologic responses of different regimens of piperacillin/tazobactam (4.5g q6h, prolonged or intermittent infusion) for treatment of nosocomial pneumonia. 2.
- Trial name
- NCT01796717
- Testing
- C Group, E Group
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Ventilator-Associated Pneumonia, Intensive Care Unit (ICU)
Artificial Intelligence-Based Evaluation of Chest X-Rays in Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in critically ill patients receiving mechanical ventilation in intensive care units (ICUs).
- Conditions
- Ventilator-Associated Pneumonia, Intensive Care Unit (ICU), Pneumonia, Bacterial, Artificial Intelligence (AI)
- Trial name
- NCT07509697
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ventilator Associated Pneumonia
Risk Factors of Ventilator-Associated Pneumonia in Critically Ill Population of Alexandria
The aim of the study is to compare cases of ventilator-associated pneumonia with matched controls of mechanically ventilated patients to identify any relevant independent risk factors for ventilator-associated pneumonia.
- Trial name
- NCT07116382
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Suez Canal University
Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections
Ontario ICU Clinical Best Practices Demonstration Project
The pragmatic issue at hand how to get physicians and nurses to use best practices… and how to measure consequences of their implementation.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections, Pressure Ulcer Prophylaxis, DVT Prophylaxis
- Trial name
- NCT00332982
- Testing
- Focused knowledge translation strategies
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
Community-acquired Pneumonia (CAP), Hospital-acquired Pneumonia (HAP)
Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia
This was a study of the safety and efficacy of ceftobiprole medocaril compared with intravenous (IV) standard-of-care cephalosporin treatment with or without vancomycin in pediatric patients with either hospital-acquired…
- Trial name
- NCT03439124
- Testing
- ceftobiprole medocaril, IV standard-of-care cephalosporin
- Where
- 19 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 138 people
- Sponsor
- Basilea Pharmaceutica
Ventilator Associated Pneumonia
Study of Knowledge Translation of Clinical Practice Guidelines for Ventilator Associated Pneumonia
The purpose of this prospective, multicentre, time-series study is to develop, implement, refine, and evaluate a sustainable behaviour change strategy in the intensive care unit (ICU).
- Trial name
- ABATEVAP (NCT00434460)
- Testing
- Education
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,320 people
- Sponsor
- Canadian Critical Care Trials Group
Ventilator Associated Pneumonia
Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia
Imipenem is a carbapenem antibacterial agent with a broad spectrum of activity against Gram-negative and Gram-positive bacteria.
- Trial name
- NCT01379157
- Testing
- Imipenem
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Prince of Songkla University
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Nosocomial Infection, Sepsis
Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model
Antimicrobial agents are frequently used empirically and include therapy for both Gram-positive and Gram-negative bacteria. In Brazil, multidrug-resistant Gram-negative pathogens are the cause of most nosocomial infections in…
- Trial name
- NCT05312034
- Testing
- Implementation of the predictive model for an antimicrobial management program
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education