Clinical trials: Healthy Adult Volunteers
Healthy, Pharmacokinetics of ASP015K and Tacrolimus
A Study to Evaluate the Drug Interaction of ASP015K and Tacrolimus
The objective of the study is to characterize the effect of multiple doses of ASP015K on the pharmacokinetics of a single oral dose or a single intravenous (IV) dose of tacrolimus.
- Trial name
- NCT01190670
- Testing
- Tacrolimus, ASP015K
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
Safety and Tolerability of STP206 in Healthy Adult Subjects
The study will assess the safety, tolerability and fecal shedding of STP206 when given as a single dose and when given as daily doses for one week.
- Trial name
- NCT00922324
- Testing
- STP206 or vehicle control
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leadiant Biosciences, Inc.
Healthy Volunteers
Study on the Mass Balance of [14C] CMS-D002 in Healthy Adult Participants in China
This phase 1, single-group study will evaluate the mass balance of [14C] CMS-D002 after a single oral dose in healthy adult participants in China.
- Trial name
- NCT07788482
- Testing
- [14C] CMS-D002
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangzhe Biotechnology Co., Ltd.
Osteogenesis Imperfecta
A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers
To understand if AGA2115 is safe and well tolerated in healthy adult volunteers.
- Trial name
- NCT06086613
- Testing
- AGA2115
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Angitia Incorporated Limited
Healthy Adult Volunteers, Nutrition
Effects of Plant Foods on Gastrointestinal and Cardiometabolic Health
The aim of this randomised controlled trial is to investigate the effects of plant foods on gastrointestinal and cardiometabolic health in healthy adults aged 30-70 years old.
- Trial name
- PLANTIFUL (NCT07586111)
- Testing
- A diet containing plant foods, A diet containing different plant foods
- Where
- United Kingdom
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy Volunteers (HV)
Drug-Drug Interaction Study of MDR-001 With Rifampin and Itraconazole in Healthy Adult Participants
A Phase I, open-label, fixed-sequence, two-part drug-drug interaction study in healthy Chinese adults to evaluate the effect of multiple-dose rifampin (Part A) or itraconazole (Part B) on the single-dose pharmacokinetics of…
- Trial name
- NCT07550621
- Testing
- MDR-001, Rifampin, Itraconazole
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- MindRank AI Ltd
Tuberculosis
Investigating Immune Responses to Aerosol BCG Challenge in Healthy UK Adults
TB043 is a clinical challenge trial primarily to evaluate the safety of BCG challenge administered by the aerosol inhaled route in healthy, BCG naive (Group 1-7) as well as historically BCG vaccinated UK adults (Group 8) .
- Trial name
- NCT03912207
- Testing
- BCG Danish
- Where
- 2 sites in United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Respiratory Syncytial Virus Infections
Pharmacokinetics and Safety of RV521 Formulations
The main aims of the study are to assess the pharmacokinetics and safety of single doses of RV521 administered as two different formulations
- Trial name
- C19007 (NCT04065698)
- Testing
- RV521
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteer
A Phase 1 Study of Mosliciguat in Healthy, Adult Males
This is a single-center, Phase 1, open-label, 3-period, fixed-sequence study to investigate the bioavailability, absorption, metabolism, excretion and the safety of mosliciguat administered to healthy male adults.
- Trial name
- NCT07185321
- Testing
- Mosliciguat, 14C mosliciguat, Dry Powder Inhaler
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pulmovant, Inc.
Healthy Volunteers
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort
This first-in-human (FiH) study consists of 2 parts: single ascending dose (SAD) with evaluation of food effect (Part 1) and multiple ascending dose (MAD) (Part 2).
- Trial name
- NCT03682484
- Testing
- MA-0211
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Healthy Volunteers
A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants
The primary purpose of this study is to characterize and compare the pharmacokinetic profiles of mitapivat following a single dose administration of 100 mg mitapivat in two tablet formulations (50 mg and 100 mg tablet strengths)…
- Trial name
- NCT04696393
- Testing
- Mitapivat tablet
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Hypertension
A Bioequivalence and Safety Study of AJU-C719 and C719R in Healthy Adult Volunteers
To evaluate the bioequivalence and safety of "AJU-C719" and "C719R" in healthy adult subjects.
- Trial name
- NCT07901114
- Testing
- Test Drug, Reference Drug
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AJU Pharm Co., Ltd.
Healthy Volunteers, Moderate to Heavy Smokers
Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult Subjects
Open label study of Pracinostat will be tested to assess the effect of food on the single-dose pharmacokinetics in healthy non-smoking and smoking adult subjects under fasted and fed conditions.
- Conditions
- Healthy Volunteers, Moderate to Heavy Smokers, Non-smokers
- Trial name
- HVFE (NCT02058784)
- Testing
- pracinostat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Healthy Volunteer
A Mass Balance Study of Oral [14C] ABBV-932 in Healthy Adult Male Participants
The main objective of this study is to assess the safety and tolerability of ABBV-932 in healthy adult male participants.
- Trial name
- NCT06953934
- Testing
- ABBV-932
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AbbVie
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-3 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-3 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421414
- Testing
- BR1015-A, BR1015-3, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Changes in Human Gut Microbiome in Healthy Adults
Prospective Randomized Controlled Pilot Study of Gut Microbiome Modulation by Nigella Sativa Seed Oil and Thymoquinone Metabolism in Healthy Volunteers
For many patients, the additive use of dietary supplements without side effects is motivating for therapy and enhances quality of life.
- Trial name
- NCT07450807
- Testing
- Intake of Thymoquinone (TQ) containing Nigella Sativa Seed Oil (NSSO) capsules
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Aysun Tekbaş
HIV Infections
Phase I Safety and Immunogenicity Preventative Vaccine Trial Based on Recombinant Tat Protein
This Phase I study is directed at evaluating the safety profile (as a primary end-point) and the immunogenicity (as a secondary end-point) of the recombinant HIV-1 Tat vaccine in healthy, immunologically competent adult subjects…
- Trial name
- ISSP-001 (NCT00529698)
- Testing
- Biologically active recombinant Tat protein
- Where
- 4 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Dyslipidemia
Study to Investigate the Effect of Food on the Pharmacokinetics/Pharmacodynamics and Safety of CKD-519(CKD-519 FDI)
The purpose this study investigate the effect of food on the pharmacokinetics/pharmacodynamics and safety of CKD-519
- Trial name
- NCT02484482
- Testing
- CKD-519 200mg / Fasting, Standard Meal, High Fat Meal
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Healthy Adult Participants, Diabetic Kidney Disease
Evaluation of MTX-439 in Healthy Adults and Adults With Diabetic Kidney Disease
This is a phase 1 randomized, double-blind, single ascending dose (SAD) and multiple ascending dose (MAD) study to assess the safety, tolerability, and Pharmacokinetics (PK) of single and multiple ascending doses of MTX-439…
- Trial name
- NCT07473323
- Testing
- MTX-439
- Where
- Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Mediar Therapeutics
Healthy Volunteer
Study To Characterize Mass Balance, Absolute Bioavailability, Fraction Absorbed And Pharmacokinetics Of 14C PF-06882961
This study is a Phase 1, open-label, non-randomized, 2-period, fixed sequence study to characterize the metabolic profile and routes of excretion of oral [14C]PF-06882961 and to evaluate the absolute oral bioavailability of…
- Trial name
- NCT04495140
- Testing
- [14C]PF-06882961, 50 mg, PF-06882961, 50 mg and [14C]PF-06882961, 100 ug
- Where
- 2 sites in Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
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