Clinical trials: Healthy Adults
Healthy Participants
A Study to Compare the Pharmacokinetics of CSL312 Administered by Prefilled Syringe Assembled to Autoinjector to the Pharmacokinetics Administered by Prefilled Syringe Assembled to Needle Safety Device in Healthy Subjects
This is an open-label, parallel-group, phase 1, single center study to assess the relative bioavailability of CSL312 administered subcutaneously via a prefilled syringe assembled to an autoinjector compared to a prefilled syringe…
- Trial name
- NCT05306275
- Testing
- CSL312
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- CSL Behring
Healthy
Bioequivalence Study of Atorvastatin Calcium Tablets, 80 mg of Dr. Reddy's Under Fasting Conditions
The purpose of this study is to compare and evaluate the single-dose oral bioavailability and to monitor the safety of subjects.
- Trial name
- NCT01645449
- Testing
- Atorvastatin Calcium Tablets, 80 mg
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Healthy Adult Participants
A Study to Evaluate the Bioequivalence of DA-5230 Compared to DA-5230-R
A study to evaluate the bioequivalence of DA-5230 compared to DA-5230-R
- Trial name
- NCT07513649
- Testing
- DA-5230, DA-5230-R
- Where
- South Korea
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Healthy
Safety and Pharmacokinetic Characteristics of DP-R206(Vitamin D3) in Healthy Adult Volunteers
The purpose of this study is to compare the pharmacokinetic characteristics of DP-R206 (150mg Ibandronate / 24,000 IU Vitamin D3 complex tablet, qd) and Vitamin D3 (24,000 IU Vitamin D3 , qd) after oral administration in healthy…
- Trial name
- NCT01577849
- Testing
- Vitamin D3, DP-R206
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Alvogen Korea
Healthy Adults
A Study to Determine the Effect of KP-001 on Metformin and Midazolam Pharmacokinetics and the Effect of Clarithromycin on KP-001 Pharmacokinetics in Healthy Adult Participants
The purpose of this study is to determine the Effects of KP-001 on Metformin (a substrate of MATE1) and Midazolam (a substrate of CYP3A4) Pharmacokinetics and the Effect of Clarithromycin (potent CYP3A4/P-gp Inhibitor) on KP-001…
- Trial name
- NCT06227832
- Testing
- KP-001, Metformin, Midazolam
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kaken Pharmaceutical
Healthy Volunteers (HV)
A Study of IBI3042 in Healthy Adult Participants
This is a randomized, investigator- and participant-blinded, placebo-controlled, parallel-group, dose-escalation Phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of single ascending oral doses of IBI3042…
- Trial name
- NCT07842393
- Testing
- Investigational Drug: IBI3042
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fortvita Biologics (USA)Inc.
Bioequivalance
Bioequivalence Study Assessing Iron Sucrose or Venofer® in Healthy Adult Subjects
This study evaluates the bioequivalence, pharmacokinetic (PK) profile, and safety and tolerability of Iron Sucrose (Test Product) relative to that of Venofer® in healthy subjects.
- Trial name
- NCT04155814
- Testing
- Iron Sucrose Injection, Venofer Injection
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Healthy
Bioequivalence Study of Tetrabenazine Tablets 25 mg Under Fed Conditions
This is an open-label, randomized, four-period, two-treatment, two-sequence, balanced, single dose, crossover, oral bioequivalence study in healthy, adult, human subjects under fed conditions.
- Trial name
- NCT03702855
- Testing
- Tetrabenazine Tablets 25 mg
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Rheumatoid Arthritis
Safety,PK/PD, Food Effect Study of Orally Administered HM71224 in Healthy Adult Male Volunteers
HM71224 is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases.
- Trial name
- NCT01765478
- Testing
- HM71224 single ascending dose, HM71224 food effect, HM71224 Multiple ascending dose
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Pulmonary Hypertension
Preliminary Human Trials of F230 Tablets
F230 is a new Class 1 chemical drug jointly developed by Beijing Contini Pharmaceutical Co., Ltd. for the treatment of pulmonary hypertension (Notification number: 2024LP01242, 2024LP01243).
- Trial name
- NCT06899815
- Testing
- F230 tablets
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Community-acquired Infection
GSK2251052 Mass Balance in Healthy Adult Subjects
Approximately 6 healthy male subjects will be administered a single 1500 mg intravenous dose of 14C-GSK2251052 under fasted conditions.
- Trial name
- NCT01475695
- Testing
- 14C GSK2251052
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Bioequivalence Study With Pharmacokinetic Endpoints, Comparing a Single Dose of Iron Sucrose Azad Injection of Azad Pharma Corporation (AG), With a Single Dose of Venofer® Injection of Vifor Corporation (AG) in Healthy Adult Volunteers
A Clinical Trial to Demonstrate the Comparability of the Two Iron Sucrose Injection Solutions Iron Sucrose Azad of Azad Pharma AG and Venofer® of Vifor Pharma AG.
- Trial name
- NCT02391181
- Testing
- Iron Sucrose Azad, Venofer®
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Azad Pharma AG
Healthy Volunteers, Renal Impairment
A Study About How ASP5354 Affects the Body in Healthy Adults and in Adults Whose Kidneys do Not Work Well
The ureter is the tube that carries urine from the kidneys to the bladder. It is difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious.
- Trial name
- NCT05495581
- Testing
- pudexacianinium chloride
- Where
- 4 sites in United States, Japan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Cystic Fibrosis
An Open-Label, Phase 1 Study in Healthy Adult Subjects to Examine the Effects of Multiple-Dose Ciprofloxacin on Ivacaftor and VX-661 in Combination With Ivacaftor
To evaluate the effect of ciprofloxacin on the pharmacokinetics (PK) of ivacaftor and on the pharmacokinetics of VX-661 when administered in combination with ivacaftor
- Trial name
- NCT02015507
- Testing
- ivacaftor, VX-661, ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
RECOMBINANT BOTULINUM VACCINE A/B
Study to Evaluate the Safety, Tolerability and Immunogenicity of Recombinant Botulinum Vaccine A/B in Healthy Adults
The purpose of this trial is to evaluate the safety and tolerability of a two-dose regimen (Day 0 and Day 28) of recombinant Botulinum Vaccine (rBV) A/B in healthy volunteers when given intramuscularly at three ascending dosage…
- Trial name
- NCT00098098
- Testing
- rBV A/B
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- DynPort Vaccine Company LLC, A GDIT Company
Healthy
A Study of Ad26.COV2.S in Adults (COVID-19)
The purpose of this study is to assess the safety and reactogenicity of Ad26.COV2.S administered intramuscularly (IM) at 2-dose levels, as 2-dose schedule in healthy participants aged greater than or equal to 20 to less than or…
- Trial name
- NCT04509947
- Testing
- Ad26.COV2.S
- Where
- 3 sites in Japan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutical K.K.
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-3 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-3 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421414
- Testing
- BR1015-A, BR1015-3, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Healthy
Alendronate Sodium 70 mg Tablet Versus Fosamax® Under Fasting Conditions.
The objective of this study is to compare the rate and extent of absorption of alendronate sodium 70 mg tablets (test) versus Fosamax® 70 mg tablets (reference) administered as a single dose of 70 mg under fasting conditions.
- Trial name
- NCT00835406
- Testing
- Alendronate Sodium Tablets 70mg, Fosamax® Tablets 70mg
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy Volunteers
A Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VIS954 in Healthy Adult Participants
This is a first-in-human (FIH), randomized, placebo-controlled, double-blind, single ascending dose (SAD) study to assess the safety and tolerability of VIS954, a monoclonal antibody, in healthy adult male and female participants.
- Trial name
- NCT06212804
- Testing
- VIS954
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Uncontrolled Hypertension
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of single and multiple ascending doses of QLS1410 in healthy Chinese adults and participants with mild…
- Trial name
- NCT07152444
- Testing
- QLS1410 (CYP11B2 inhibitor)
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
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