Clinical trials: Healthy Adults
Acute Myocardial Infarction
A Study of CSL112 in Healthy Adults and in Adults With Moderate Renal Impairment
This is a phase 1 multicenter, randomized, double-blind, placebo-controlled, ascending dose study to investigate the pharmacokinetics (PK), safety, and tolerability of CSL112 in adult subjects with moderate renal impairment and…
- Trial name
- NCT02427035
- Testing
- CSL112
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 32 people
- Sponsor
- CSL Behring
Insulin Sensitivity/Resistance
Assessment of Insulin Sensitivity in Healthy Adults by a 13C-glucose Breath Test : Method Development and Validation
The current research project aims to assess the insulin resistance (less sensitivity), from measures of insulin and glucose in response to a standard oral intake of glucose (standardized oral glucose tolerance test).
- Trial name
- NCT06766617
- Testing
- 75 gr Glucose
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
The Dose-response "Pilot" Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
To determine the dose-response relationship for Clobex TM (clobetasol propionate) Lotion, 0.05%. This information will be used to estimate the ED50, D1, D2 parameters for use in a full bioequivalence study.
- Trial name
- NCT00864240
- Testing
- Clobex TM (Clobetasol) 0.05% Lotion, single exposure
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
COVID-19
A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector)
This is a phase II, randomised, double-blinded and placebo-controlled clinical trial in healthy adults above 18 years of age. This clinical trial is designed to evaluate the immunogenicity and safety of Ad5-nCoV which encodes for…
- Trial name
- CTII-nCoV (NCT04341389)
- Testing
- Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)
- Where
- China
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
Influenza
Follow-up of Immunogenicity of Influenza Virus Vaccine, AdimFlu-S (A/H1N1), in Healthy Volunteers After 6 Months
In the spring of 2009, a recently emerged novel influenza A (H1N1) virus was first identified in Mexico and USA and it has continued to spread globally.
- Trial name
- NCT01096238
- Volunteers
- 185 people
- Sponsor
- National Taiwan University Hospital
Moderate Hepatic Impairment, Severe Hepatic Impairment
Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients
This study is being conducted to evaluate the major Nitazoxanide (NTZ) active metabolite in adult participants with hepatic impairment and healthy adults.
- Conditions
- Moderate Hepatic Impairment, Severe Hepatic Impairment, Liver Diseases
- Trial name
- NCT05116826
- Testing
- Nitazoxanide
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Genfit
Healthy Volunteers
Drug-drug Interaction Study of CTP-543 and Oral Contraceptives in Healthy Female Subjects
This is a Phase 1, fixed sequence, multiple dose, open-label study of the effect of CTP-543 on oral contraceptive pharmacokinetics in healthy female subjects.
- Trial name
- NCT04309643
- Testing
- CTP-543, Combined oral contraceptive containing Ethinyl estradiol (EE) and Levonorgestrel (LNG)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals
Autoimmune Diseases, Multiple Sclerosis
First-in-Human Trial in Healthy Adult Volunteers to Evaluate Safety, Tolerability and PK of LAPIX Study Drug; LPX-TI641
A Phase I First-in-Human, Randomized, Double-Blind, Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate Safety, Tolerability, and Pharmacokinetics after Single and Multiple Oral Dose of LPX-TI641.
- Trial name
- NCT05853835
- Testing
- LPX-TI641
- Where
- 2 sites in United States, Jordan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- LAPIX Therapeutics Inc.
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, and Fecal Pharmacokinetics of BX002-A in Healthy Adults
The purpose of study BMX-02-001 is to evaluate the safety, tolerability and feasibility of orally administered BX002-A to deliver viable bacteriophages to the gut.
- Trial name
- NCT04737876
- Testing
- BX002-A
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- BiomX, Inc.
Healthy Subjects, Dyslipidaemias
Study Of Pharmacokinetics and Pharmacodynamics Effects Of GSK256073A On Healthy Volunteers
The purpose of this study is to compare the effects of single and repeat doses of GSK256073 with placebo in HVT subjects.
- Trial name
- NCT00488449
- Testing
- GSK256073A tablets
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cytomegalovirus Infections
A Study of Human Cytomegalovirus (HCMV) Vaccine SPYVLP01 With and Without Adjuvants
The main purpose of the study is to evaluate the safety and immunogenicity of SPYVLP01 in two different doses with and without adjuvants in healthy adults aged 18-50 years old.
- Trial name
- SPYVAC01 (NCT06145178)
- Testing
- SPYVAC01
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SpyBiotech Limited
Multiple Sclerosis
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, [18F]-FZTA, to detect inflammation in the brain.
- Trial name
- FZTA Pilot (NCT07115017)
- Testing
- [18F] FZTA
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Absorption; Chemicals
Safety and Pharmacokinetics of Phaffia Rhodozyma Astaxanthin
Astaxanthin is a xanthophyll carotenoid, a naturally occurring lipid-soluble red pigment. Apart from its coloring ability it is also a strong antioxidative ingredient and contains health-promoting properties.
- Trial name
- NCT03807050
- Testing
- Astaxanthin
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NextFerm Technologies LTD
Pulmonary Inflammation
Phase 1 Study Assessing the Safety and Tolerability of CTX-4430
The purpose of this study is to assess the safety and tolerability of CTX-4430 capsules taken orally once daily in normal healthy volunteers.
- Trial name
- NCT01748838
- Testing
- CTX-4430, Mannitol
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Celtaxsys, Inc.
Attention - no Condition is Being Assessed - Healthy Adults
Investigation of Locus Coeruleus Function in Sustained Attention
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity…
- Trial name
- LC (NCT06041048)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy Volunteers
Bioequivalence Study Between Capoten Versus Captopril Reference Product in Healthy Adult Participants Under Fasting Conditions
This is a bioequivalence study to compare Capoten (test product [T]) versus captopril (reference product [R]) produced by Mylan Pharmaceuticals Spain, in healthy adult participants under fasting condition.
- Trial name
- NCT04878315
- Testing
- Capoten, Captopril
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID 19
Evaluate Safety and Pharmacokinetics of HLX70 in Healthy Adult Volunteers
A Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Phase I Clinical Study to Evaluate Safety and Pharmacokinetics of HLX70 in Healthy Adult Volunteers
- Trial name
- NCT04561076
- Testing
- HLX70
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hengenix Biotech Inc
Healthy
RDEA3170 Tablet and Capsule Bioavailability Study
The purpose of this study is to determine the relative bioavailability of RDEA3170 capsules compared with RDEA3170 tablets.
- Trial name
- NCT02448368
- Testing
- RDEA3170,10 mg, RDEA3170, 2.5 mg, RDEA3170, 5 mg
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ardea Biosciences, Inc.
Healthy
Does Motor Imagery Training Enhance Control of Movement in Older Adults?
The goal of this clinical trial is learn about motor imagery training (i.e. imagining a task) with healthy older adults. The main question this clinical trial aims to answer is: Will imagining a task improve control of force…
- Trial name
- NCT05669131
- Testing
- Motor imagery training
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Adults
Safety, Tolerability, and Pharmacokinetics of Oral EC5026 in Healthy Subjects
This is a first-in-human study with EC5026, a new drug candidate intended to treat neuropathic pain. The purpose of the study is to provide initial safety, tolerability, and pharmacokinetics data of single ascending oral doses of…
- Trial name
- NCT04228302
- Testing
- EC5026 oral capsule
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- EicOsis Human Health Inc.