Clinical trials: Healthy Donors
Healthy Donors, Myeloproliferative Diseases
CAR-NK Cells Production and Expansion From Patients With Lympho or Myeloproliferative Disorders and From Healthy Donors
Recent studies demonstrated the safety and efficacy of allogeneic and autologous infusion of NK cells as adoptive immunotherapy in malignant hematological diseases and solid tumors.NK cells are innate immunity effectors with…
- Conditions
- Healthy Donors, Myeloproliferative Diseases, Lymphoproliferative Disorders
- Trial name
- NCT06727383
- Testing
- peripheral blood collection, leukapheresis
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Clostridium Difficile Infection
Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection
CDI (Clostridium difficile infection) causes diarrheal illness and can cause colitis which may be fatal. A patient being treated for CDI has a 10-25% chance of developing relapse. Recurrent CDI is on the rise.
- Trial name
- NCT01372943
- Testing
- "synthetic stool" or pure cultures of probiotic intestinal bacteria
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Queen's University
Fibromyalgia
Fecal Microbiome Transplantation From Healthy Donors to Individuals With Fibromyalgia
This study aims to investigate if a fecal microbiome transplantation (FMT) from healthy donors can reduce symptoms of fibromyalgia, a condition causing chronic pain that is difficult to treat and diagnose.
- Trial name
- FM-FMT-RCT (NCT06424041)
- Testing
- Fecal Microbiome Transplantation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Healthy Volunteer
A Prospective Study to Evaluate the Specificity of the Cobas TaqScreen MPX Test for Use on the Cobas s 201 System for Screening Plasma Pools From Source Plasma Donors for the Presence of HBV DNA, HCV RNA, and HIV-1 RNA
This study will evaluate the specificity of the cobas TaqScreen MPX Test for the simultaneous detection of HBV DNA, HCV RNA and HIV-1 Group M in a minimum of 100,000 individual donor samples in 96-unit pools.
- Trial name
- NCT00520273
- Testing
- cobas s 201 TaqScreen MPX Test
- Where
- 3 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Hypertension, Cardiovascular Diseases
Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.
The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the…
- Trial name
- NCT05798481
- Testing
- Mixture of Sodium Nitrite and N-acetylcysteine (NAC) crytals.
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Influenza, Human
Study of Immune Responses in Healthy Adults Receiving Live Influenza Virus Vaccines
This study seeks to understand the host factors that affect the replication and immune response of seasonal and candidate pandemic live attenuated influenza vaccine (LAIV) in humans and to develop biomarkers that can predict the…
- Trial name
- NCT01674205
- Testing
- A/swine/Missouri/4296424/2006 (H2N3) x A/Ann Arbor/6/60 ca (H2N3 MO 2006/AA ca), A/chicken/Hong Kong/G9/97 (H9N2) x A/Ann Arbor/6/60 ca (H9N2 G9/AA ca), 2012-2013 trivalent seasonal live attenuated influenza vaccine (FluMist®)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Participants
Study of the Effect of a 5-Day Regimen of Study Drug on Peripheral Stem Cell Mobilization in Healthy Participants
A multi-center, open-label, single-arm clinical study to assess effects of a 5-day regimen of 10 micrograms per kilogram (mcg/kg) of tbo-filgrastim administered subcutaneously daily on the mobilization of cluster of…
- Trial name
- GRANIX (NCT03029000)
- Testing
- Tbo-filgrastim
- Where
- 9 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Healthy Apheresis Donors
Citrate Effects and Bone Density in Long-Term Apheresis Donors
This study will examine the effects of repeated apheresis procedures on bone density and calcium balance. Apheresis is a procedure for collecting large numbers of a specific blood component, such as white cells (leukapheresis) or…
- Trial name
- NCT00073060
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- National Institutes of Health Clinical Center (CC)